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The pharmacokinetic screening of multiple components of the Nao Mai Tong formula in rat plasma by liquid chromatography tandem mass spectrometry combined with pattern recognition method and its application to comparative pharmacokinetics
Publication date: 30 November 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 131 Author(s): Chunwei Wu, Lu Zhao, Yueying Rong, Guoxue Zhu, Shengwang Liang, Shumei Wang The Nao Mai Tong formula (NMT) is composed of Rhubarb, Ginseng, Ligusticum wallichii and Pueraria in a ratio of 3:3:2:2 (w/w) and is a well-known traditional Chinese prescription that has been clinically employed for treating ischemia cerebrovascular disease. The goal of this study was to investigate the pharmacokinetics of multiple components (chryohol-8-O-β-D-glucoyroide, physcion-8-O-β-D-glucopyranoside, aloe-emodin, rhein, emodi...
Source: Journal of Pharmaceutical and Biomedical Analysis - September 12, 2016 Category: Drugs & Pharmacology Source Type: research

Emodin accentuates atrial natriuretic peptide secretion in cardiac atria.
Abstract Emodin, an active anthraquinone constituent isolated from the rhubarb, a traditional Chinese herbal medicine which is widely used in clinical treatment, has cardiovascular protective properties. However, it remains unclear whether the cardiovascular protective actions of emodin are related to an activation of cardiac natriuretic hormone secretion. The purpose of the present study was to explore the effect of emodin on the secretion of ANP, a member of the family of cardiac natriuretic hormones, and its mechanisms involved. Experiments were performed in isolated perfused beating rabbit atria allowing measu...
Source: European Journal of Pharmacology - April 18, 2014 Category: Drugs & Pharmacology Authors: Hai Zhou G, Zhang F, Nong Wang X, Jeong Kwon O, Gill Kang D, Sub Lee H, Nan Jin S, Woo Cho K, Fu Wen J Tags: Eur J Pharmacol Source Type: research