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Ro25-6981 alleviates neuronal damage and improves cognitive deficits by attenuating oxidative stress via the Nrf2/ARE pathway in ischemia/reperfusion rats
Cerebral ischemia ‒reperfusion injury (CIRI) refers to the phenomenon that structural damage and dysfunction of the brain are further aggravated when blood perfusion is restored after cerebral ischemia for a certain time, which mainly causes apoptosis or necrosis of nerve cells.1 CIRI will result in severe cognitiv e and motor dysfunction.2,3 The current treatments are mainly thrombolysis, intervention, nutritional nerve, and rehabilitation training, but they cannot completely restore the neurological function of patients.
Source: Journal of Stroke and Cerebrovascular Diseases - December 29, 2022 Category: Neurology Authors: Xiuxian Gao, Fei Chen, Xinqi Xu, Jinfeng Liu, Fuxing Dong, Yaping Liu Source Type: research

Update on Intensive Care Unit Management of Stroke
Anasthesiol Intensivmed Notfallmed Schmerzther. 2022 Mar;57(3):222-229. doi: 10.1055/a-1374-1932. Epub 2022 Mar 23.ABSTRACTIn this review, we provide an update on the intensive care unit (ICU) management of ischemic stroke. Over the last decade, new evidence has led to rapid changes in the early management of patients admitted with acute ischemic stroke. Nevertheless, stroke remains a leading cause of disability. Consequently, a significant number of patients with acute ischemic stroke require ICU level care. The most frequent reasons for ICU admissions are large infarction with potential swelling, reduced level of conscio...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - March 23, 2022 Category: Intensive Care Authors: Farid Salih Alexandra Becker Nicolai Andrees Hannah Tempel Source Type: research

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