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Management of Atrial Fibrillation
Atrial fibrillation remains the most prevalent cardiac arrhythmia, and its incidence is increasing as the population ages. Common conditions associated with an increased incidence include advanced age, hypertension, heart failure, and valvular heart disease. Patients with atrial fibrillation may complain of palpitations, fatigue, and decreased exercise tolerance or may be completely asymptomatic. Options for treating patients who experience atrial fibrillation include rate-controlling drugs such as digoxin, β-blockers, and calcium channel blockers or a rhythm-controlling strategy with agents such as sodium channel blo...
Source: Journal of Intensive Care Medicine - October 29, 2015 Category: Intensive Care Authors: Zamani, P., Verdino, R. J. Tags: Analytic Reviews Source Type: research

Role of calcium desensitization in the treatment of myocardial dysfunction after deep hypothermic circulatory arrest
This study investigated the acute overall hemodynamic and metabolic effects of epinephrine and levosimendan, a calcium sensitizer, on myocardial function after rewarming from DHCA. Methods: Forty male Wistar rats (400--500 g) underwent cardiopulmonary bypass (CPB) through central cannulation and were cooled to a core temperature of 13[degree sign]C to 15[degree sign]C within 30 minutes. After DHCA (20 minutes) and CPB-assisted rewarming (60 minutes) rats were randomly assigned to 60 minute intravenous infusion with levosimendan (0.2 mug/kg/min; n = 15), epinephrine (0.1 mug/kg/min; n = 15) or saline (control; n = 10). Syst...
Source: Critical Care - October 20, 2013 Category: Intensive Care Authors: Alessio RungatscherSeth HallströmAlice GiacomazziDaniele LinardiElisabetta MilaniMaddalena TessariGiovanni LucianiTiziano ScarabelliAlessandro MazzuccoGiuseppe Faggian Source Type: research