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Pseudoginsenoside-F11 improves long-term neurological function and promotes neurogenesis after transient cerebral ischemia in mice
Publication date: Available online 20 November 2019Source: Neurochemistry InternationalAuthor(s): Linlin Yuan, Shibo Sun, Xiaohan Pan, Liqin Zheng, Yuting Li, Jingyu Yang, Chunfu WuAbstractStroke is the leading cause of long-term motor disability and cognitive impairment beside the acute brain injury. Recently, neurogenesis has become an attractive strategy for the chronic recovery of stroke. Our previous study showed that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, isolated from leaves of Panax pseudoginseng subsp, exerted neuroprotective effects on stroke by alleviating autophagy/lysosomal defects and repres...
Source: Neurochemistry International - November 21, 2019 Category: Neuroscience Source Type: research

Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke
Publication date: Available online 30 December 2016 Source:Neurochemistry International Author(s): Stephanie M. Davis, Keith R. Pennypacker During ischemic stroke, neurons and glia are subjected to damage during the acute and neuroinflammatory phases of injury. Production of reactive oxygen species (ROS) from calcium dysregulation in neural cells and the invasion of activated immune cells are responsible for stroke-induced neurodegeneration. Scientists have failed thus far to identify antioxidant-based drugs that can enhance neural cell survival and improve recovery after stroke. However, several groups have demonstrated ...
Source: Neurochemistry International - December 30, 2016 Category: Neuroscience Source Type: research

Unexpected complication in a rat stroke model: exacerbation of secondary pathology in the thalamus by subacute intraarterial administration of human bone marrow-derived mesenchymal stem cells
Jukka Jolkkonen
Source: Journal of Cerebral Blood Flow and Metabolism - February 27, 2015 Category: Neuroscience Authors: Bhimashankar MitkariErja KerkeläJohanna NystedtMatti KorhonenJukka Jolkkonen Tags: β-amyloid calcium cell therapy cerebral ischemia secondary pathology Source Type: research