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Human astrocytic grid networks patterned in parylene-C inlayed SiO2 trenches.
Abstract Recent literature suggests that glia, and in particular astrocytes, should be studied as organised networks which communicate through gap junctions. Astrocytes, however, adhere to most surfaces and are highly mobile cells. In order to study, such organised networks effectively in vitro it is necessary to influence them to pattern to certain substrates whilst being repelled from others and to immobilise the astrocytes sufficiently such that they do not continue to migrate further whilst under study. In this article, we demonstrate for the first time how it is possible to facilitate the study of organised ...
Source: Biomaterials - August 3, 2016 Category: Materials Science Authors: Jordan MD, Raos BJ, Bunting AS, Murray AF, Graham ES, Unsworth CP Tags: Biomaterials Source Type: research