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Spontaneous Recovery of Upper Extremity Motor Impairment After Ischemic Stroke: Implications for Stem Cell-Based Therapeutic Approaches
AbstractPreclinical studies suggest that stem cell therapy (SCT) may improve sensorimotor recovery after stroke. Upper extremity motor impairment (UEMI) is common after stroke, often entailing substantial disability. To evaluate the feasibility of post-stroke UEMI as a target for SCT, we examined a selected sample of stroke patients potentially suitable for SCT, aiming to assess the frequency and recovery of UEMI, as well as its relation to activity limitations and participation restrictions. Patients aged 20 –75 years with first-ever ischemic stroke, and National Institutes of Health Stroke Scale (NIHSS) scores 1–18,...
Source: Translational Stroke Research - February 14, 2017 Category: Neurology Source Type: research

In Context News in brief
The Pilot Investigation of Stem Cells in Stroke (PISCES) phase 1, first-in-man study assessed the safety of single intracerebral doses of CTX-DP —a drug derived from the immortalised human neural stem-cell line, CTX0E03. This open-label, single-site, dose-escalation study recruited 13 men aged 60 years and older with stable disability (National Institutes of Health Stroke Scale [NIHSS] score ≥6 and modified Rankin Scale score of 2–4) f ollowing ischaemic stroke 6–60 months before enrolment. 11 men received implantation of single doses of 2 million, 5 million, 10 million, or 20 million cells by stereotactic ipsilate...
Source: Lancet Neurology - September 13, 2016 Category: Neurology Tags: In Context Source Type: research