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Novel anticoagulants for stroke prevention in atrial fibrillation: safety issues in the elderly.
Abstract Vitamin K antagonists (VKAs) are the most widely used anticoagulants for stroke prevention in patients with atrial fibrillation (AF). Recently, the US FDA approved three novel anticoagulants that work through inhibition of coagulation cascade independent of Vitamin K-dependent enzymatic reactions and, therefore, should have less food-drug interactions. Since AF is a disease of the aging heart, it is important to assess safety and efficacy of these new anticoagulants in elderly patients. We reviewed age-related changes in pharmacokinetics and pharmacodynamics observed with senescence and the effects of the...
Source: Pharmacological Reviews - November 1, 2013 Category: Drugs & Pharmacology Authors: Strunets A, Mirza M, Sra J, Jahangir A Tags: Expert Rev Clin Pharmacol Source Type: research