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Magnetic Nanobubble Mechanical Stress Induces the Piezo1 ‐Ca2+‐BMP2/Smad Pathway to Modulate Neural Stem Cell Fate and MRI/Ultrasound Dual Imaging Surveillance for Ischemic Stroke
Magnetic nanobubbles (MNBs) assembled from magnetic nanoparticles are fabricated. When interacting with neural stem cells (NSCs), these MNB nanostructures can contract and expand with volumetric oscillation, leading to a change in intramembrane mechanical properties. Therefore, MNBs can serve as acoustic sensors to transduce Piezo1-Ca2+- triggered BMP2/Smad signals regulating NSC development and can be tracked using magnetic resonance and ultrasound dual imaging. AbstractNeural stem cells (NSCs) are used to treat various nervous system diseases because of their self-renewal ability and multidirectional differentiation pote...
Source: Small - June 9, 2022 Category: Nanotechnology Authors: Jing Li,
Yao Zhang,
Zhichao Lou,
Mingxi Li,
Lin Cui,
Zhenrong Yang,
Lijuan Zhang,
Yu Zhang,
Ning Gu,
Fang Yang Tags: Research Article Source Type: research
