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The therapeutic benefits of intravenously administrated nanoparticles in stroke and age-related neurodegenerative diseases
Curr Pharm Des. 2022 Jun 8. doi: 10.2174/1381612828666220608093639. Online ahead of print.ABSTRACTThe mean global lifetime risk of neurological disorders such as stroke, Alzheimer's disease (AD), and Parkinson's disease (PD) has shown a large effect on economy and society.Researchersare stillstruggling to find effective drugs to treatneurological disordersand drug delivery through the blood-brain barrier (BBB) is a major challenge to be overcome. The BBB is a specialized multicellular barrier between the peripheral blood circulation and the neural tissue. Unique and selective features of the BBB allow it to tightly control...
Source: Current Pharmaceutical Design - June 9, 2022 Category: Drugs & Pharmacology Authors: Mehdi Farhoudi Saeed Sadigh-Eteghad Javad Mahmoudi Afsaneh Farjami Afsaneh Farjami Mohammad Mahmoudian Sara Salatin Source Type: research

Snake venom three-finger toxins and their potential in drug development targeting cardiovascular diseases.
Abstract Cardiovascular diseases such as coronary and peripheral artery diseases, venous thrombosis, stroke, hypertension, and heart failure are enormous burden to health and economy globally. Snake venoms have been the sources of discovery of successful therapeutics targeting cardiovascular diseases. For example, the first-in-class angiotensin-converting enzyme inhibitor captopril was designed largely based on bradykinin-potentiating peptides from Bothrops jararaca venom. In the recent years, sensitive and high throughput approaches drive discovery and cataloging of new snake venom toxins. As one of the largest c...
Source: Biochemical Pharmacology - June 20, 2020 Category: Drugs & Pharmacology Authors: Manjunatha Kini R, Yeow Koh C Tags: Biochem Pharmacol Source Type: research