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Infectious Disease: Influenza

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Total 27336 results found since Jan 2013.

Longevity and Determinants of Protective Humoral Immunity Following Pandemic Influenza Infection.
Conclusions: The longevity of protective humoral immunity following influenza infection has important implications for influenza transmission dynamics and vaccination policy, and identification of its predictive cellular immune correlate could guide vaccine development and evaluation. PMID: 25506631 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2014 Category: Respiratory Medicine Authors: Sridhar S, Begom S, Hoschler K, Bermingham A, Adamson W, Carman W, Riley S, Lalvani A Tags: Am J Respir Crit Care Med Source Type: research

Immunity to influenza. Preventing infection and regulating disease.
PMID: 25635487 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 1, 2015 Category: Respiratory Medicine Authors: Allen EK, Thomas PG Tags: Am J Respir Crit Care Med Source Type: research

Platelet Activation and Aggregation Promote Lung Inflammation and Influenza Virus Pathogenesis.
Conclusions: The intricate relationship between hemostasis and inflammation has major consequences in influenza virus pathogenesis, and anti-platelet drugs might be explored to develop new anti-inflammatory treatment against influenza virus infections. Key words: Lung injury, novel drugs, Flu pathogenesis, pneumonia, platelets. PMID: 25664391 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 9, 2015 Category: Respiratory Medicine Authors: Lê VB, Schneider JG, Boergeling Y, Berri F, Ducatez M, Guerin JL, Adrian I, Errazuriz-Cerda E, Frasquilho S, Antunes L, Lina B, Bordet JC, Jandrot-Perrus M, Ludwig S, Riteau B Tags: Am J Respir Crit Care Med Source Type: research

Impaired Antibody-mediated Protection and Defective IgA B Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus.
Conclusions: This observed specific defect in IgA memory may partly explain RSV's ability to cause recurrent symptomatic infections. If so, vaccines able to induce durable RSV-specific IgA responses may be more protective than those generating systemic antibody alone. PMID: 25730467 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 2, 2015 Category: Respiratory Medicine Authors: Habibi MS, Jozwik A, Makris S, Dunning J, Paras A, DeVincenzo JP, de Haan CA, Wrammert J, Openshaw PJ, Chiu C, The MOSAIC Investigators Tags: Am J Respir Crit Care Med Source Type: research

Targeting PI3K-p110α Suppresses Influenza Viral Infection in Chronic Obstructive Pulmonary Disease.
Conclusions: The increased susceptibility of individuals with COPD to influenza likely results from impaired antiviral responses, which is mediated by increased PI3K-p110α activity. This pathway may be targeted therapeutically in COPD, or in healthy individuals, during seasonal or pandemic outbreaks, to prevent and/or treat influenza. PMID: 25751541 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 9, 2015 Category: Respiratory Medicine Authors: Hsu AC, Starkey MR, Hanish I, Parsons K, Haw TJ, Howland LJ, Barr I, Mahony JB, Foster PS, Knight DA, Wark PA, Hansbro PM Tags: Am J Respir Crit Care Med Source Type: research

Natural T Cell Mediated Protection Against Seasonal and Pandemic Influenza: Results of the Flu Watch Cohort Study.
CONCLUSIONS: Naturally occurring cross-protective T cell immunity protects against symptomatic PCR-confirmed disease in those with evidence of infection and helps to explain why many infections do not cause symptoms. Vaccines stimulating T cells may provide important cross-protective immunity. PMID: 25844934 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - April 6, 2015 Category: Respiratory Medicine Authors: Hayward AC, Wang L, Goonetilleke N, Fragaszy EB, Bermingham A, Copas A, Dukes O, Millett ER, Nazareth I, Nguyen-Van-Tam JS, Watson JM, Zambon M, Johnson AM, McMichael AJ, Flu Watch Group Tags: Am J Respir Crit Care Med Source Type: research

Dysregulation of Anti-viral Function of CD8+T Cells in the COPD Lung: Role of the PD1/PDL1 Axis.
CONCLUSIONS: This study has established a signal of cytotoxic immune dysfunction and aberrant immune regulation in the COPD lung that may explain both the susceptibility to viral infection and the excessive, inflammation associated with exacerbations. PMID: 26517304 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - October 30, 2015 Category: Respiratory Medicine Authors: McKendry RT, Spalluto CM, Burke H, Nicholas B, Cellura D, Al-Shamkhani A, Staples KJ, Wilkinson TM Tags: Am J Respir Crit Care Med Source Type: research

The Effects of LAIV on Nasopharyngeal Bacteria in Healthy 2-4 Year Olds: a Randomized Controlled Trial.
CONCLUSION: In the absence of any safety signals despite widespread use of the vaccine, these findings suggest that bacterial density and thus, transmission rates amongst children and to other age groups may rise following attenuated influenza infections without associated clinical disease. LAIV could therefore be used as an experimental tool to elucidate the dynamics of transmission of nasopharyngeal bacteria. PMID: 26742001 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 7, 2016 Category: Respiratory Medicine Authors: Thors V, Christensen H, Morales-Aza B, Vipond I, Muir P, Finn A Tags: Am J Respir Crit Care Med Source Type: research

Syndecan-1 Attenuates Lung Injury During Influenza Infection By Potentiating c-Met Signaling to Suppress Epithelial Apoptosis.
CONCLUSIONS: Our work shows that cell-associated syndecan-1 has an important role in regulating lung injury. Together, our findings demonstrate a novel mechanism in which cell membrane-associated syndecan-1 regulates the innate immune response to influenza infection by facilitating cytoprotective signals through c-Met signaling to limit bronchial epithelial apoptosis thereby attenuating lung injury and inflammation. PMID: 26959387 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 9, 2016 Category: Respiratory Medicine Authors: Brauer R, Ge L, Schlesinger SY, Birkland TP, Huang Y, Parimon T, Lee V, McKinney BL, McGuire JK, Parks WC, Chen P Tags: Am J Respir Crit Care Med Source Type: research

Influenza-Associated Aspergillosis in Critically Ill Patients.
PMID: 28387526 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - April 7, 2017 Category: Respiratory Medicine Authors: van de Veerdonk FL, Kolwijck E, Lestrade PP, Hodiamont CJ, Rijnders BJ, van Paassen J, Haas PJ, Oliveira Dos Santos C, Kampinga GA, Bergmans DC, van Dijk K, de Haan AF, van Dissel J, van der Hoeven HG, Verweij PE, Dutch Mycoses Study Group Tags: Am J Respir Crit Care Med Source Type: research

Short-term Elevation of Fine Particulate Matter Air Pollution and Acute Lower Respiratory Infection.
CONCLUSIONS: In this large sample of urban/suburban patients, short-term exposure to elevated PM2.5 air pollution was associated with greater healthcare utilization for ALRI in both young children, older children, and adults. Further exploration is needed of causal interactions between PM2.5 and ALRI. PMID: 29652174 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - April 13, 2018 Category: Respiratory Medicine Authors: Horne BD, Joy EA, Hofmann MG, Gesteland PH, Cannon JB, Lefler JS, Blagev DP, Korgenski EK, Torosyan N, Hansen GI, Kartchner D, Pope Iii CA Tags: Am J Respir Crit Care Med Source Type: research

Clinical Significance of Upper Airway Virus Detection in Critically Ill Hematology Patients.
CONCLUSIONS: Respiratory virus detection in the upper airway by multiplex PCR assay is common in critically ill hematology patients. In patients with ARF, respiratory virus detection was independently associated with ICU mortality. Multiplex PCR assay may prove helpful for the risk stratification of hematology patients with ARF. Studies to understand whether respiratory tract viruses play a causal role in outcomes are warranted. PMID: 30230909 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - September 19, 2018 Category: Respiratory Medicine Authors: Legoff J, Zucman N, Lemiale V, Mokart D, Pène F, Lambert J, Kouatchet A, Demoule A, Vincent F, Nyunga M, Bruneel F, Contejean A, Mercier-Delarue S, Rabbat A, Lebert C, Perez P, Meert AP, Benoit D, Schwebel C, Jourdain M, Darmon M, Resche-Rigon M, Azoulay Tags: Am J Respir Crit Care Med Source Type: research

Wood Smoke Exposure Alters Human Inflammatory Responses to Viral Infection in a Sex-Specific Manner: A Randomized, Placebo-Controlled Study.
CONCLUSIONS: WSP exposure resulted in minimal modification of LAIV-induced responses in aggregate analysis. In contrast, analyzing WSP-induced modification of LAIV responses in the sexes separately unmasked sex-specific differences in response to exposure. These data highlight the need for additional studies to understand sex-specific pollutant-induced effects. Clinical trial registration available at www.clinicaltrials.gov, ID NCT02183753. PMID: 30360637 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - October 26, 2018 Category: Respiratory Medicine Authors: Rebuli ME, Speen AM, Martin EM, Addo KA, Pawlak EA, Glista-Baker E, Robinette C, Zhou H, Noah TL, Jaspers I Tags: Am J Respir Crit Care Med Source Type: research

Aetiology and Risk Factors for Mortality in an Adult Community-Acquired Pneumonia Cohort in Malawi.
CONCLUSIONS: In the ART era, CAP in Malawi remains predominantly HIV-associated with a large proportion attributable to potentially vaccine-preventable pathogens. Strategies to increase early detection and treatment of tuberculosis and improve supportive care, in particular the correction of hypoxaemia, should be evaluated in clinical trials to address CAP-associated mortality. PMID: 30625278 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 9, 2019 Category: Respiratory Medicine Authors: Aston SJ, Ho A, Jary H, Huwa J, Mitchell T, Ibitoye S, Greenwood S, Joekes E, Daire A, Mallewa J, Everett D, Nyirenda M, Faragher B, Mwandumba HC, Heyderman RS, Gordon SB Tags: Am J Respir Crit Care Med Source Type: research

Two Randomized Trials of Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonization.
PMID: 30758980 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 13, 2019 Category: Respiratory Medicine Authors: Rylance J, de Steenhuijsen Piters WAA, Mina MJ, Bogaert D, French N, Ferreira DM, and the EHPC-LAIV study group Tags: Am J Respir Crit Care Med Source Type: research