Filtered By:
Infectious Disease: Tuberculosis

This page shows you your search results in order of relevance. This is page number 5.

Order by Relevance | Date

Total 35529 results found since Jan 2013.

Asymptomatic HIV-infected Individuals on Antiretroviral Therapy Exhibit Impaired Lung CD4(+) T Cell Responses to Mycobacteria.
Conclusion. AM and mycobacteria-specific alveolar CD4+ T cell responses in HIV-infected adults on ART for <4 years are impaired and may partly explain the high risk of TB in HIV-infected individuals on ART. Strategies to augment ART to improve lung immune cell function and reduce the high incidence of TB in HIV-infected adults who initiate ART should be investigated. PMID: 25225948 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - September 16, 2014 Category: Respiratory Medicine Authors: Jambo KC, Banda DH, Afran L, Kankwatira AM, Malamba RD, Allain TJ, Gordon SB, Heyderman RS, Russell DG, Mwandumba HC Tags: Am J Respir Crit Care Med Source Type: research

Risk of Tuberculosis After Recent Exposure: a 10-year Follow-up Study of Contacts in Amsterdam.
Abstract The risk of tuberculosis (TB) for infected contacts is often mentioned to be 5 to 10 percent, but estimates are based on studies conducted decades ago, thus may not reflect current conditions. Our aim was to estimate the risk of TB among contacts with infection and compare with literature. A retrospective cohort study was performed using records on contacts of pulmonary TB (PTB) patients at the Public Health Service Amsterdam (PHS), 2002-2011. TB cases were identified during follow-up until October 2012; co-prevalent if ≤180 days and incident if >180 days after TB diagnosis of index patient. Cumulati...
Source: American Journal of Respiratory and Critical Care Medicine - September 29, 2014 Category: Respiratory Medicine Authors: Sloot R, Schim van der Loeff MF, Kouw PM, Borgdorff MW Tags: Am J Respir Crit Care Med Source Type: research

Lung-residing Myeloid-derived Suppressors Display Dual Functionality in Murine Pulmonary Tuberculosis.
Conclusion: Our data reveal that MDSCs provide a niche for pathogen survival and tailor immunity in TB. These findings suggest MDSCs as amenable targets for host-directed therapies and emphasize them as cellular-immune regulators during chronic inflammatory conditions, including chronic infections and microbial complications of neoplastic disorders. PMID: 25275852 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - October 2, 2014 Category: Respiratory Medicine Authors: Knaul JK, Jörg S, Oberbeck-Mueller D, Heinemann E, Scheuermann L, Brinkmann V, Mollenkopf HJ, Yeremeev V, Kaufmann SH, Dorhoi A Tags: Am J Respir Crit Care Med Source Type: research

Disseminated tuberculosis with splenic tuberculosis abscess rupture. A rare presentation.
PMID: 25271747 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Tang T, Hsu Y, Lee JJ Tags: Am J Respir Crit Care Med Source Type: research

Risk Assessment of Tuberculosis in Immunocompromised Patients - A TBNET Study.
Conclusions: Among immunocompromised patients evaluated in this study, progression towards tuberculosis was highest in HIV-infected individuals and was poorly predicted by TST or IGRAs Clinical trial registration information available at www.clinicaltrials.gov, ID NCT00707317. PMID: 25303140 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - October 10, 2014 Category: Respiratory Medicine Authors: Sester M, van Leth F, Bruchfeld J, Bumbacea D, Cirillo DM, Gorek Dilektasli A, Domínguez J, Duarte R, Ernst M, Oner Eyuboglu F, Gerogianni I, Girardi E, Goletti D, Janssens JP, Julander I, Lange B, Latorre I, Losi M, Markova R, Matteelli A, Milburn H, Ra Tags: Am J Respir Crit Care Med Source Type: research

Eat and Suppress: The Two-Faced Role of Myeloid-derived Suppressor Cells in Tuberculosis.
PMID: 25360727 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - November 1, 2014 Category: Respiratory Medicine Authors: Rieber N, Hartl D Tags: Am J Respir Crit Care Med Source Type: research

Cigarette Smoking Impairs Human Pulmonary Immunity to Mycobacterium tuberculosis.
Conclusions: In smokers, the pulmonary compartment has a number of macrophage-specific immune impairments which provide some mechanistic explanations whereby cigarette smoking renders a patient susceptible to tuberculosis infection and disease. PMID: 25390734 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - November 12, 2014 Category: Respiratory Medicine Authors: O'Leary SM, Coleman MM, Chew WM, Morrow C, McLaughlin AM, Gleeson LE, O'Sullivan MP, Keane J Tags: Am J Respir Crit Care Med Source Type: research

Xpert MTB/RIF False Detection of Rifampin-Resistant Tuberculosis from Prior Infection.
PMID: 25436783 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - December 1, 2014 Category: Respiratory Medicine Authors: Kelly JD, Grace Lin SY, Barry PM, Keh C, Higashi J, Metcalfe JZ Tags: Am J Respir Crit Care Med Source Type: research

Daily Rifapentine for Treatment of Pulmonary Tuberculosis: a Randomized, Dose-ranging Trial.
Conclusions: Daily rifapentine was well tolerated and safe. High rifapentine exposures were associated with high levels of sputum sterilization at completion of intensive phase. Further studies are warranted to determine if regimens that deliver high rifapentine exposures can shorten treatment duration to less than 6 months. Clinical trial registration information available at www.clinicaltrials.gov, ID NCT00694629. PMID: 25489785 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - December 9, 2014 Category: Respiratory Medicine Authors: Dorman SE, Savic RM, Goldberg S, Stout JE, Schluger N, Muzanyi G, Johnson JL, Nahid P, Hecker EJ, Heilig CM, Bozeman L, Feng PJ, Moro RN, Mac Kenzie W, Dooley KE, Nuermberger EL, Vernon A, Weiner M, the Tuberculosis Trials Consortium Tags: Am J Respir Crit Care Med Source Type: research

The Dynamics of QuantiFERON®-TB Gold In-Tube Conversion and Reversion in a Cohort of South African Adolescents.
Conclusions. In this tuberculosis-endemic setting, annual risk of infection was extremely high, while QFT and TST conversion concordance were higher and QFT reversion rates were lower than reported from low-burden settings. PMID: 25562578 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 6, 2015 Category: Respiratory Medicine Authors: Andrews JR, Hatherill M, Mahomed H, Hanekom WA, Campo M, Hawn TR, Wood R, Scriba TJ Tags: Am J Respir Crit Care Med Source Type: research

Bactericidal Activity of Pyrazinamide and Clofazimine Alone and in Combinations with Pretomanid and Bedaquiline.
Abstract Rationale New regimens to shorten tuberculosis treatment and manage drug-resistant and human immunodeficiency virus infected tuberculosis patients are urgently needed. Experimental and clinical evidence suggests that the new drugs bedaquiline (B) and pretomanid (Pa), combined with an existing drug, pyrazinamide (Z), and a repurposed drug, clofazimine (C), may assist treatment shortening of both drug-susceptible and drug-resistant tuberculosis. Objective To evaluate the 14-day bactericidal activity of C and Z in monotherapy and in combinations with Pa and B. Methods Groups of 15 treatment-naïve, sputum sm...
Source: American Journal of Respiratory and Critical Care Medicine - January 26, 2015 Category: Respiratory Medicine Authors: Diacon AH, Dawson R, von Groote-Bidlingmaier F, Symons G, Venter A, Donald PR, van Niekerk C, Everitt D, Hutchings J, Burger DA, Schall R, Mendel CM Tags: Am J Respir Crit Care Med Source Type: research

Revised definitions of multidrug-resistant tuberculosis treatment outcomes: closer to the reality?
PMID: 25635495 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 1, 2015 Category: Respiratory Medicine Authors: Bastard M, Bonnet M, du Cros P, Khamraev AK, Hayrapetyan A, Kimenye K, Khurkhumal S, Dlamini T, Telnov A, Sanchez-Padilla E, Hewison C, Varaine F Tags: Am J Respir Crit Care Med Source Type: research

Optimizing the Dose of Rifapentine to Treat Tuberculosis. It's Elementary.
PMID: 25635488 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 1, 2015 Category: Respiratory Medicine Authors: Lauzardo M, Ashkin D Tags: Am J Respir Crit Care Med Source Type: research

A Dose Ranging Trial to Optimize the Dose of Rifampin in the Treatment of Tuberculosis.
Conclusions: Two weeks of rifampin up to 35 mg/kg was safe and well tolerated. There was a non-linear increase in exposure to rifampin without an apparent ceiling effect and a greater estimated fall in bacterial load in the higher dosing groups. Clinical trial registration available at www.clinicaltrials.gove, ID NCT01392911. PMID: 25654354 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 5, 2015 Category: Respiratory Medicine Authors: Boeree MJ, Diacon AH, Dawson R, Narunsky K, du Bois J, Venter A, Phillips PP, Gillespie SH, Mc Hugh TD, Hoelscher M, Heinrich N, Rehal S, van Soolingen D, van Ingen J, Magis-Escurra C, Burger D, Plemper van Balen G, Aarnoutse RE Tags: Am J Respir Crit Care Med Source Type: research

Reply: Overestimation of Coprevalent and Underestimation of Incident Tuberculosis in Close Contacts.
PMID: 25679111 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2015 Category: Respiratory Medicine Authors: Sloot R, Schim van der Loeff MF, Kouw PM, Borgdorff MW Tags: Am J Respir Crit Care Med Source Type: research