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Infectious Disease: Tuberculosis

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Total 35529 results found since Jan 2013.

Reply to: Intervening on Social Determinants for Better Outcomes in Pediatric Tuberculosis Management
Am J Respir Crit Care Med. 2023 Apr 19. doi: 10.1164/rccm.202304-0629LE. Online ahead of print.NO ABSTRACTPMID:37075313 | DOI:10.1164/rccm.202304-0629LE
Source: American Journal of Respiratory and Critical Care Medicine - April 19, 2023 Category: Respiratory Medicine Authors: Leonardo Martinez Heather J Zar Source Type: research

Performance of the CURB-65 Score in Predicting Critical Care Interventions in Patients Admitted With Community-Acquired Pneumonia
ConclusionPatients with CURB-65 score less than or equal to 2 were often admitted to the ICU and received critical care interventions. Given this finding and the relatively low sensitivity of CURB-65 for critical care intervention, clinicians should exercise caution when using CURB-65 to guide disposition. Future ED-based clinical prediction rules may benefit from calibration to proximal endpoints.
Source: Annals of Emergency Medicine - August 3, 2018 Category: Emergency Medicine Source Type: research

Tuberculosis Pathways to Care and Transmission of Multidrug-Resistance in India
CONCLUSIONS: The association of MDR with young age, crowding and low genotypic diversity raise concerns of ongoing MDR transmission fueled by long delays in care. Delays are decreasing with GeneXpert use, suggesting the need for routine use in presumptive TB. Qualitatively, we identify the need to improve patient retention in the NTEP and highlight patients' trust relationship with private providers. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:34706203 | DOI:10.1164/rccm.202012-4333OC
Source: American Journal of Respiratory and Critical Care Medicine - October 27, 2021 Category: Respiratory Medicine Authors: Sachin R Atre Jayshri D Jagtap Mujtaba I Faqih Yogita K Dumbare Trupti U Sawant Sunil L Ambike Jitendra S Bhawalkar Sandeep K Bharaswadkar Padmaja K Jogewar Ramji S Adkekar Balasaheb P Hodgar Vaishali Jadhav Nitin D Mokashi Jonathan E Golub Avika Dixit Ma Source Type: research

Forgiveness Is the Attribute of the Strong: Nonadherence and Regimen-Shortening in Drug-Sensitive TB
CONCLUSIONS: With the current appetite for, and progress towards, shorter drug-sensitive tuberculosis regimens worldwide, we offer reassurance that shorter regimens are not necessarily less forgiving of non-adherence. Given the importance of continuation phase adherence, patient support during this period should not be neglected.PMID:35952354 | DOI:10.1164/rccm.202201-0144OC
Source: American Journal of Respiratory and Critical Care Medicine - August 11, 2022 Category: Respiratory Medicine Authors: Helen R Stagg Jennifer A Thompson Marc Ci Lipman Derek J Sloan Mary Flook Katherine L Fielding Critical Path to TB Drug Regimens Source Type: research

Mycobacteria-specific Cytokine Responses Detect TB Infection and Distinguish Latent from Active TB.
CONCLUSIONS: We identified several mycobacteria-specific cytokine biomarkers with the potential to be exploited for immunodiagnosis. Incorporation of these biomarkers into future immunodiagnostic assays for TB could result in substantial gains in sensitivity, and allow the distinction between LTBI and active TB based on a blood test alone. PMID: 26030187 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - June 1, 2015 Category: Respiratory Medicine Authors: Tebruegge M, Dutta B, Donath S, Ritz N, Forbes B, Camacho-Badilla K, Clifford V, Zufferey C, Robins-Browne R, Hanekom W, Graham SM, Connell T, Curtis N Tags: Am J Respir Crit Care Med Source Type: research

A Functional TOLLIP Variant is Associated with BCG-Specific Immune Responses and Tuberculosis.
CONCLUSIONS: TOLLIP deficiency is associated with decreased BCG-specific T-cell responses and increased susceptibility to tuberculosis. We hypothesize that the heightened antibacterial monocyte responses following vaccination of TOLLIP-deficient infants are responsible for decreased BCG-specific T cell responses. Activating TOLLIP may provide a novel adjuvant strategy for BCG vaccination. PMID: 28463648 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - May 2, 2017 Category: Respiratory Medicine Authors: Shah JA, Musvosvi M, Shey M, Horne DJ, Wells RD, Peterson GJ, Cox JS, Daya M, Hoal EG, Lin L, Gottardo R, Hanekom WA, Scriba TJ, Hatherill M, Hawn TR Tags: Am J Respir Crit Care Med Source Type: research

The Elusive "Gold" Standard for Detecting Mycobacterium tuberculosis Infection.
PMID: 23322793 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - January 15, 2013 Category: Respiratory Medicine Authors: Mancuso JD, Bernardo J, Mazurek GH Tags: Am J Respir Crit Care Med Source Type: research

Induction and Regulation of T Cell Immunity by the Novel TB Vaccine M72/AS01 in South African Adults.
CONCLUSIONS: M72/AS01 is clinically well tolerated in Mtb-infected and uninfected adults, induces high frequencies of multifunctional T cells, and boosts distinct T cell responses primed by natural Mtb infection. Moreover, these results provide important novel insights into how this immunity may be appropriately regulated, following novel TB vaccination of Mtb-infected and uninfected individuals. PMID: 23306546 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 10, 2013 Category: Respiratory Medicine Authors: Day CL, Tameris M, Mansoor N, van Rooyen M, de Kock M, Geldenhuys H, Erasmus M, Makhethe L, Hughes EJ, Gelderbloem S, Bollaerts A, Bourguignon P, Cohen J, Demoitié MA, Mettens P, Moris P, Sadoff JC, Hawkridge A, Hussey GD, Mahomed H, Ofori-Anyinam O, Han Tags: Am J Respir Crit Care Med Source Type: research

Cough Aerosols of Mycobacterium tuberculosis Predict New Infection: A Household Contact Study.
CONCLUSIONS: Cough aerosols of M. tuberculosis are produced by a minority of TB patients but predict transmission better than sputum smear microscopy or culture. Cough aerosols may help identify the most infectious TB patients and thus, improve the cost-effectiveness of TB control programs. PMID: 23306539 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 10, 2013 Category: Respiratory Medicine Authors: Jones-López EC, Namugga O, Mumbowa F, Ssebidandi M, Mbabazi O, Moine S, Mboowa G, Fox MP, Reilly N, Ayakaka I, Kim S, Okwera A, Joloba M, Fennelly KP Tags: Am J Respir Crit Care Med Source Type: research

Is Passive Diagnosis Enough? The Impact of Subclinical Disease on Diagnostic Strategies for Tuberculosis.
CONCLUSIONS: Subclinical disease may limit the impact of current diagnostic strategies for TB. Active detection of undiagnosed prevalent cases may achieve greater population-level TB control than increasing passive case detection. PMID: 23262515 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - December 21, 2012 Category: Respiratory Medicine Authors: Dowdy DW, Basu S, Andrews JR Tags: Am J Respir Crit Care Med Source Type: research

Interferon Gamma Release Assays in the Diagnosis of Latent Tuberculosis Infection Among Immunocompromised Adults.
Abstract Immunocompromised persons with latent tuberculosis infection are at increased risk for tuberculosis reactivation compared to the general population. Tuberculin skin test, the traditional assay for diagnosing LTBI (latent tuberculosis infection), has reduced accuracy in immunocompromised patients. Interferon-gamma release assays (IGRAs) are in vitro blood tests that measure T-cell release of interferon-gamma following stimulation by antigens unique to Mycobacterium tuberculosis. Here we review the data for the use of QuantiFERON-TB Gold In-Tube (QFT-GIT) and T-SPOT.TB, the two currently available IGRAs, in...
Source: American Journal of Respiratory and Critical Care Medicine - December 21, 2012 Category: Respiratory Medicine Authors: Redelman-Sidi G, Sepkowitz KA Tags: Am J Respir Crit Care Med Source Type: research

Lessons Learned from a Tuberculosis Contact Investigation Associated with a Disaster Volunteer after the 2011 Great East Japan Earthquake.
PMID: 23725629 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - June 1, 2013 Category: Respiratory Medicine Authors: Kanamori H, Uchiyama B, Hirakata Y, Chiba T, Okuda M, Kaku M Tags: Am J Respir Crit Care Med Source Type: research