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Infectious Disease: Tuberculosis

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Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline.
Conclusions: New recommendations are made for the choice and number of drugs in a regimen, the duration of intensive and continuation phases, and the role of injectable drugs for MDR-TB. On the basis of these recommendations, an effective all-oral regimen for MDR-TB can be assembled. Recommendations are also provided on the role of surgery in treatment of MDR-TB and for treatment of contacts exposed to MDR-TB and treatment of isoniazid-resistant TB. PMID: 31729908 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - November 14, 2019 Category: Respiratory Medicine Authors: Nahid P, Mase SR, Migliori GB, Sotgiu G, Bothamley GH, Brozek JL, Cattamanchi A, Cegielski JP, Chen L, Daley CL, Dalton TL, Duarte R, Fregonese F, Horsburgh CR, Ahmad Khan F, Kheir F, Lan Z, Lardizabal A, Lauzardo M, Mangan JM, Marks SM, McKenna L, Menzie Tags: Am J Respir Crit Care Med Source Type: research

The Risk of Falsely Declaring Non-Inferiority of Novel Latent Tuberculosis Treatment in Large Trials.
PMID: 31816247 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - December 8, 2019 Category: Respiratory Medicine Authors: Abubakar I, Cobelens FG, Rangaka MX Tags: Am J Respir Crit Care Med Source Type: research

Quantitative Interferon Gamma Release Assay and Tuberculin Skin Test Results to Predict Incident Tuberculosis: A Prospective Cohort Study.
CONCLUSIONS: Implementation of higher thresholds for QFT-GIT, T-SPOT.TB and TST modestly increases PPV for incident TB, but markedly reduces sensitivity. Novel biomarkers or validated multivariable risk algorithms are required to improve prediction of incident TB. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). PMID: 31825645 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - December 10, 2019 Category: Respiratory Medicine Authors: Gupta RK, Lipman M, Jackson C, Sitch A, Southern J, Drobniewski F, Deeks JJ, Tsou CY, Griffiths C, Davidson J, Campbell C, Stirrup O, Noursadeghi M, Kunst H, Haldar P, Lalvani A, Abubakar I Tags: Am J Respir Crit Care Med Source Type: research

Controlled Human Infection Models - Is it Really Feasible to Give People Tuberculosis?
PMID: 31904993 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 5, 2020 Category: Respiratory Medicine Authors: McShane H Tags: Am J Respir Crit Care Med Source Type: research

Lower BCG Protection Against Mycobacterium tuberculosis Infection After Exposure to Beijing Strains.
PMID: 31914319 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 7, 2020 Category: Respiratory Medicine Authors: Verrall AJ, Chaidir L, Ruesen C, Apriani L, Koesoemadinata RC, van Ingen J, Sharples K, van Crevel R, Alisjahbana B, Hill PC, INFECT study group Tags: Am J Respir Crit Care Med Source Type: research

Optimising β-lactams Against Tuberculosis.
PMID: 31922901 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 9, 2020 Category: Respiratory Medicine Authors: de Jager VR, Vanker N, van der Merwe L, van Brakel E, Lelievre J, Muliaditan M, Barros-Aguirre D, Diacon AH Tags: Am J Respir Crit Care Med Source Type: research

Bedaquiline-resistant Tuberculosis: Dark Clouds on the Horizon.
PMID: 32053752 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 12, 2020 Category: Respiratory Medicine Authors: Andres S, Merker M, Heyckendorf J, Kalsdorf B, Rumetshofer R, Indra A, Hofmann-Thiel S, Hoffmann H, Lange C, Niemann S, Maurer FP Tags: Am J Respir Crit Care Med Source Type: research

Erratum: Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline.
Authors: PMID: 32057258 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2020 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Clarity with INHindsight: High-Dose Isoniazid for Drug-Resistant Tuberculosis with inhA Mutations.
PMID: 32078783 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 19, 2020 Category: Respiratory Medicine Authors: Wasserman S, Furin J Tags: Am J Respir Crit Care Med Source Type: research

Reply to: High-dose First-line Treatment Regimen for Recurrent Rifampicin-susceptible Tuberculosis.
PMID: 32130866 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 3, 2020 Category: Respiratory Medicine Authors: Dooley KE, Miyahara S, von Groote-Bidlingmaier F, Sun X, Hafner R, Rosenkranz SL, Ignatius EH, Nuermberger EL, Moran L, Donahue K, Swindells S, Vanker N, Diacon AH Tags: Am J Respir Crit Care Med Source Type: research

High-dose First-line Treatment Regimen for Recurrent Rifampicin-susceptible Tuberculosis.
PMID: 32130864 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 3, 2020 Category: Respiratory Medicine Authors: Decroo T, de Jong BC, Piubello A, Souleymane MB, Lynen L, Van Deun A Tags: Am J Respir Crit Care Med Source Type: research

Reply to: Trials of Tuberculosis Preventive Therapy in People with HIV Infection.
PMID: 32282235 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - April 12, 2020 Category: Respiratory Medicine Authors: Stout JE, Turner NA, Belknap RW, Horsburgh CR, Sterling TR, Phillips PPJ Tags: Am J Respir Crit Care Med Source Type: research

Trials of Tuberculosis Preventive Therapy in People with HIV Infection.
PMID: 32282226 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - April 12, 2020 Category: Respiratory Medicine Authors: Swindells S, Hughes M, Chaisson RE Tags: Am J Respir Crit Care Med Source Type: research

Rifapentine Population Pharmacokinetics and Dosing Recommendations for Latent Tuberculosis Infection.
CONCLUSIONS: Weight-based dosing of rifapentine should be removed from clinical guidelines and higher doses for HIV-positive patients should be considered to provide equivalent efficacy. PMID: 32412342 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - May 14, 2020 Category: Respiratory Medicine Authors: Hibma JE, Radtke KK, Dorman SE, Jindani A, Dooley KE, Weiner M, McIlleron HM, Savic RM Tags: Am J Respir Crit Care Med Source Type: research

Platelets Restrict the Oxidative Burst in Phagocytes and Facilitate Primary Progressive Tuberculosis.
CONCLUSION: Platelets are detrimental in primary progressive pulmonary tuberculosis, orchestrate lung immunity by modulating innate immune responsiveness and may be amenable to new interventions for this deadly disease. PMID: 32421376 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - May 17, 2020 Category: Respiratory Medicine Authors: Scheuermann L, Pei G, Domaszewska T, Zyla J, Oberbeck-Müller D, Bandermann S, Feng Y, Ruiz Moreno JS, Opitz B, Mollenkopf HJ, Kaufmann SH, Dorhoi A Tags: Am J Respir Crit Care Med Source Type: research