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Infectious Disease: Tuberculosis

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Total 35529 results found since Jan 2013.

Differential Recognition of Mtb-specific Epitopes as a Function of Tuberculosis Disease History.
CONCLUSIONS: Preferential loss of T cell reactivity to Mtb epitopes that are homologous to bacteria in the microbiome in persons with previous TB disease may reflect long-term effects of antibiotic TB treatment on the microbiome. PMID: 28759253 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - July 31, 2017 Category: Respiratory Medicine Authors: Scriba TJ, Carpenter C, Carrasco Pro S, Sidney J, Musvosvi M, Rozot V, Seumois G, Rosales SL, Vijayanand P, Goletti D, Makgotlho E, Hanekom W, Hatherill M, Peters B, Sette A, Lindestam Arlehamn CS Tags: Am J Respir Crit Care Med Source Type: research

An Expanding Role for Environmental Microbes in Shaping the Immune Response to Infection with Mycobacterium Tuberculosis.
PMID: 28841029 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - August 25, 2017 Category: Respiratory Medicine Authors: Lewinsohn D Tags: Am J Respir Crit Care Med Source Type: research

A Prospective Validation of a Clinical Algorithm to Detect Tuberculosis in Child Contacts.
PMID: 29035095 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - October 16, 2017 Category: Respiratory Medicine Authors: Martinez L, Handel A, Shen Y, Chakraburty S, Quinn FD, Stein CM, Malone LL, Zalwango S, Whalen CC Tags: Am J Respir Crit Care Med Source Type: research

Cracking the Vaccine Code in Tuberculosis.
Abstract Considerable effort has been devoted to developing a T cell mediated vaccine against tuberculosis (TB).  However, to date, the evidence that this approach can provide protection against Mycobacterium tuberculosis infection has been limited in pre-clinical models and disappointing in a clinical trial. Our fundamental lack of understanding of protective immunity against TB is still the major impediment to vaccine development. In this perspective article, we aim to distinguish the innate immune mechanisms of host-resistance from T cell mediated host-tolerance, and call for novel approaches to be inv...
Source: American Journal of Respiratory and Critical Care Medicine - October 18, 2017 Category: Respiratory Medicine Authors: Divangahi M, Behr MA Tags: Am J Respir Crit Care Med Source Type: research

B Cells Producing Type I Interferon Modulate Macrophage Polarization in Tuberculosis.
CONCLUSION: Type I interferon produced by Mtb-stimulated B cells favors macrophage polarization towards a regulatory/anti-inflammatory phenotype during Mtb infection. PMID: 29161093 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - November 21, 2017 Category: Respiratory Medicine Authors: Bénard A, Sakwa I, Schierloh P, Colom A, Mercier I, Tailleux L, Jouneau L, Boudinot P, Al-Saati T, Lang R, Rehwinkel J, Loxton AG, Kaufmann SH, Anton-Leberre V, O'Garra A, Del Carmen Sasiain M, Gicquel B, Fillatreau S, Neyrolles O, Hudrisier D Tags: Am J Respir Crit Care Med Source Type: research

Evaluating UK National Guidance for Screening of Children for TB: A Prospective Multi-centre Study.
Conclusions In this low prevalence setting we saw no incident cases of TB disease in children who were TST-positive but IGRA-negative and did not receive treatment for TB infection. Following the latest NICE guidance, significantly more children will require medication. PMID: 29190430 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - November 30, 2017 Category: Respiratory Medicine Authors: Kampmann B, Seddon JA, Paton J, Nademi Z, Keane D, Williams B, Williams A, Liebeschutz S, Riddell A, Bernatoniene J, Patel S, Martinez N, McMaster P, Basu-Roy R, Welch SB Tags: Am J Respir Crit Care Med Source Type: research

Float Like Bacilli, STING Like a B: Type I Interferons in Tuberculosis.
PMID: 29262261 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - December 20, 2017 Category: Respiratory Medicine Authors: Ernst JD Tags: Am J Respir Crit Care Med Source Type: research

Platelets Regulate Pulmonary Inflammation and Tissue Destruction in Tuberculosis.
CONCLUSIONS: Platelets drive a pro-inflammatory, tissue-degrading phenotype in TB. PMID: 29420060 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 8, 2018 Category: Respiratory Medicine Authors: Fox KA, Kirwan DE, Whittington AM, Krishnan N, Robertson BD, Gilman RH, López JW, Singh S, Porter JC, Friedland JS Tags: Am J Respir Crit Care Med Source Type: research

Cause or Effect - the Elusive Role of Regulatory T Cells in Tuberculosis.
PMID: 29490145 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 28, 2018 Category: Respiratory Medicine Authors: Schwander S, Keane J Tags: Am J Respir Crit Care Med Source Type: research

Platelets and Tuberculosis: Small Cells, Not So Innocent Bystanders.
PMID: 29509503 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 6, 2018 Category: Respiratory Medicine Authors: Cox D, Keane J Tags: Am J Respir Crit Care Med Source Type: research

Clinical Management of Multidrug-resistant Tuberculosis in 16 European Countries.
CONCLUSIONS: Conventional standard MDR-TB treatment regimens resulted in a higher frequency of failure compared to individualized treatments. Overall, cure from MDR-TB is substantially more frequent than previously anticipated, and poorly reflected by WHO outcome definitions. PMID: 29509468 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 6, 2018 Category: Respiratory Medicine Authors: Günther G, van Leth F, Alexandru S, Altet N, Avsar K, Bang D, Barbuta R, Bothamley G, Ciobanu A, Crudu V, Danilovits M, Dedicoat M, Duarte R, Gualano G, Kunst H, de Lange W, Leimane V, McLaughlin AM, Magis-Escurra C, Muylle I, Polcová V, Popa C, Rumetsh Tags: Am J Respir Crit Care Med Source Type: research

Update in Tuberculosis and Non-tuberculous Mycobacteria 2017.
PMID: 29537298 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 14, 2018 Category: Respiratory Medicine Authors: Abubakar I, Gupta RK, Rangaka MX, Lipman M Tags: Am J Respir Crit Care Med Source Type: research

Four-gene Pan-African Blood Signature Predicts Progression to Tuberculosis.
CONCLUSIONS: Collectively, we developed a simple whole blood-based PCR test to predict tuberculosis in household contacts from diverse African populations, with potential for implementation in national TB contact investigation programs. PMID: 29624071 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - April 6, 2018 Category: Respiratory Medicine Authors: Suliman S, Thompson E, Sutherland J, Weiner Rd J, Ota MOC, Shankar S, Penn-Nicholson A, Thiel B, Erasmus M, Maertzdorf J, Duffy FJ, Hill PC, Hughes EJ, Stanley K, Downing K, Fisher ML, Valvo J, Parida SK, van der Spuy G, Tromp G, Adetifa IMO, Donkor S, Ho Tags: Am J Respir Crit Care Med Source Type: research

Drug-resistant Tuberculosis in Europe. What are We Waiting for?
PMID: 29669214 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - April 18, 2018 Category: Respiratory Medicine Authors: Monedero-Recuero I Tags: Am J Respir Crit Care Med Source Type: research

Drug Penetration Gradients Associated with Acquired Drug Resistance in Tuberculosis Patients.
CONCLUSIONS: These data inform interventional strategies relevant to drug delivery, dosing, and diagnostics to prevent the development of acquired resistance. The role of high intracavitary penetration as a biomarker of antibiotic efficacy, when assessing new regimens, requires clarification. PMID: 29877726 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - June 7, 2018 Category: Respiratory Medicine Authors: Dheda K, Lenders L, Magombedze G, Srivastava S, Raj P, Arning E, Ashcraft P, Bottiglieri T, Wainwright H, Pennel T, Linegar A, Moodley L, Pooran A, Pasipanodya JG, Sirgel FA, van Helden PD, Wakeland E, Warren RM, Gumbo T Tags: Am J Respir Crit Care Med Source Type: research