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Insights into Omicron's Low Fusogenicity through < em > In Silico < /em > Molecular Studies on Spike-Furin Interactions
Bioinform Biol Insights. 2023 Jul 28;17:11779322231189371. doi: 10.1177/11779322231189371. eCollection 2023.ABSTRACTThe Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant and its subvariants have a unique set of mutations. Two of those mutations (N679 K and P681 H) reside close to the S1 /S2 furin cleavage site (FCS; 685-686). When these mutations reside together, they exert less-efficient membrane fusion than wild type and most other variants of concern such as the Delta variant. Here, we in silico targeted these mutations to find out which of the amino acids and interactions change plays the key...
Source: Bioinformatics and Biology Insights - August 2, 2023 Category: Bioinformatics Authors: Spencer Mark Mondol Md Hasib Md Belayet Hasan Limon A S M Rubayet Ul Alam Source Type: research

Virtual patient education for hypertension: The truth about behavioral change
World J Cardiol. 2023 Jun 26;15(6):324-327. doi: 10.4330/wjc.v15.i6.324.ABSTRACTAnti-hypertensive education is an important public health intervention to decrease the mortality and burden of the disease. Using digital technologies for education as a part of preventive measures for hypertension is a cost-effective approach and helps low-income communities and vulnerable populations overcome barriers to healthcare access. The coronavirus disease 19 pandemic further highlighted the need of new health interventions to address health inequalities. Virtual education is helpful to improve awareness, knowledge, and attitude toward...
Source: World Journal of Cardiology - July 3, 2023 Category: Cardiology Authors: Zeynep Yukselen Yuvaraj Singh Sarat Malempati Mahati Dasari Pramukh Arun Kumar Eddison Ramsaran Source Type: research

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