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Progress and Prospect of Single-molecular ClpX ATPase Researching system-a mini-review.
Abstract ClpXP in Escherichia coli is a proteasome degrading protein substrates. It consists of one hexamer of ATPase (ClpX) and two heptamers of peptidase (ClpP). The ClpX binds ATP and translocates the substrate protein into the ClpP chamber by binding and hydrolysis of ATP. At single molecular level, ClpX harnesses cycles of power stroke (dwell and burst) to unfold the substrates, then releases the ADP and Pi. Based on the construction and function of ClpXP, especially the recent progress on how ClpX unfold protein substrates, in this mini-review, a currently proposed single ClpX molecular model system detected...
Source: Gene - January 9, 2021 Category: Genetics & Stem Cells Authors: Kang ZH, Liu YT, Gou Y, Deng QR, Hu ZY, Li GR Tags: Gene Source Type: research