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Infectious Disease: Superbugs
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Total 614 results found since Jan 2013.
One-tube RPA-CRISPR Cas12a/Cas13a rapid detection of methicillin-resistant Staphylococcus aureus
Anal Chim Acta. 2023 Oct 16;1278:341757. doi: 10.1016/j.aca.2023.341757. Epub 2023 Aug 26.ABSTRACTAt present, methicillin-resistant Staphylococcus aureus (MRSA) has caused a serious impact on a global scale. The infection and carrier rate of MRSA in the community is increasing year by year, but there is still no convenient detection system for on-site rapid detection. It is very important to select a rapid detection system to accurately and quickly detect patients infected with MRSA. We have developed a high-efficient single-tube detection platform based on RPA and CRISPR reaction system to detect the genes of mecA and clf...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Yujie Liu Hui Liu Guanliu Yu Wenbo Sun Muhammad Aizaz Guiwen Yang Lei Chen Source Type: research
Microplastics enrichment characteristics of antibiotic resistance genes and pathogens in landfill leachate
This study conducted incubation experiments with polyethylene terephthalate (PET) and polypropylene (PP) MPs in landfill leachate which were about 3-5 years old (PL) and 5-10 years old (AL). After incubation, the bacterial cells colonized and grew on the surface of MPs, inducing the increase of oxygenated oxygen functional groups (e.g., hydroxyl, carbonyl) on the MPs surface. Real-time PCR indicated that MPs selectively enriched ARGs, such as genes tetM, tetC, mcr-1, aac(6')-Ib-cr, blaTEM and blaSHV in leachate. The diversity of bacterial communities on MPs was significantly increased in AL leachate, but decreased in PL le...
Source: Chemosphere - September 8, 2023 Category: Chemistry Authors: Cheng Qiu Yiwei Zhou Hua Wang Yixuan Chu Lei Zheng Yongmin Chen Yali Song Chengran Fang Source Type: research
Pyrrole-thiazolidinone hybrids as a new structural class of broad-spectrum anti-infectives
Eur J Med Chem. 2023 Aug 25;260:115757. doi: 10.1016/j.ejmech.2023.115757. Online ahead of print.ABSTRACTA series of pyrrole-thiazolidinone hybrids was designed, synthesized and evaluated for activities against ESKAP bacteria panel and mycobacterial pathogens. From the series, compound 9d showed prominent activity against S. aureus (MIC = 0.5 μg/mL) and compound 9k showed the most promising activity against M. tuberculosis H37Rv (MIC = 0.5 μg/mL). Potent derivatives were found to be non-toxic when tested against Vero cells. Compound 9d upon evaluation in vitro against several MRSA and VRSA strains produced activity compa...
Source: European Journal of Medicinal Chemistry - September 2, 2023 Category: Chemistry Authors: Shujauddin Ahmed Alka Mital Abdul Akhir Deepanshi Saxena Mohammad Naiyaz Ahmad Arunava Dasgupta Sidharth Chopra Rahul Jain Source Type: research
Design and synthesis of broad-spectrum antimicrobial amphiphilic peptidomimetics to combat drug-resistance
Bioorg Chem. 2023 Aug 6;140:106766. doi: 10.1016/j.bioorg.2023.106766. Online ahead of print.ABSTRACTThe gradual depletion of antibiotic discovery pipeline makes the antibiotic resistance a difficult clinical problem and a global health emergency. The membrane-active antimicrobial peptides (AMPs) attracted much attention due to a lower tendency to bacterial resistance than traditional antibiotics. However, some immanent drawbacks of AMPs may hamper their application in combating antibiotic resistance in the long run, such as susceptible to enzymatic degradation and low cell permeability. Herein, we report the design and sy...
Source: Bioorganic Chemistry - August 12, 2023 Category: Chemistry Authors: Yating Chen Zifan Ye Wenteng Zhen Lu Zhang Xiangyang Min Yipeng Wang Feng Liu Ma Su Source Type: research
Thiazole-based analogues as potential antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and their SAR elucidation
This article reviews the recent progress of thiazole compounds as potential antibacterial compounds and examines the structure-activity relationship (SAR) in various directions. It covers articles published from 2018 to 2023, providing a comprehensive platform to plan and develop new thiazole-based small MRSA growth inhibitors with minimal side effects.PMID:37542993 | DOI:10.1016/j.ejmech.2023.115689
Source: European Journal of Medicinal Chemistry - August 5, 2023 Category: Chemistry Authors: Jiaojiao Guo Zhouling Xie Wei Ruan Qidong Tang Dan Qiao Wufu Zhu Source Type: research
