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Management of ischemic stroke in the acute phase
The objective of this article is to provide a general overview of the current management of patients with acute ischemic stroke aiming at improving post-stroke outcome.PMID:34481684 | DOI:10.1016/j.revmed.2021.08.003
Source: Revue de Medecine Interne - September 5, 2021 Category: Internal Medicine Authors: G Duloquin M Graber L Baptiste S Mohr L Garnier M Ndiaye C Blanc-Labarre M Hervieu-B ègue G-V Osseby M Giroud Y B éjot Source Type: research

Acute management of ischemic stroke in 2017.
Authors: Blanc-Labarre C, Delpont B, Hervieu-Bègue M, Osseby GV, Ricolfi F, Thouant P, Giroud M, Béjot Y Abstract Acute management of ischemic stroke is a burning topic in 2017 since stroke represents the leading cause of acquired handicap in adults. Over the last past years, major improvement took place, especially with the demonstration of the efficacy of mechanical thrombectomy, thus needing to better organize care pathways, and optimize access to neurologists and interventional neuroradiology platforms. Intensive care stroke units remain the pivotal place of patients' management. A multidisciplinary coordinat...
Source: Revue de Medecine Interne - September 6, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Management of mesenteric ischemia in the era of intestinal stroke centers: The gut and lifesaving strategy.
Authors: Nuzzo A, Corcos O Abstract Mesenteric ischemia is a gut and life-threatening, medical and surgical, digestive and vascular emergency. Mesenteric ischemia is the result of an arterial or venous occlusion, a vasospasm secondary to low-flow states in intensive care patients, aortic clamping during vascular surgery or intestinal transplantation. Progression towards mesenteric infarction and its complications is unpredictable and correlates with high rates of mortality or a high risk of short bowel syndrome in case of survival. Thus, mesenteric ischemia should be diagnosed and treated at an early stage, when gu...
Source: Revue de Medecine Interne - March 6, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

In patient with symptomatic peripheral arterial disease who had undergone lower-extremity revascularization, does rivaroxaban 2.5  mg twice daily plus aspirin reduce the composite risk of acute limb ischemia, major amputation for vascular causes, myocardial infarction, ischemic stroke or cardiovascular death compared to aspirin alone while being safe?
[In patient with symptomatic peripheral arterial disease who had undergone lower-extremity revascularization, does rivaroxaban 2.5 mg twice daily plus aspirin reduce the composite risk of acute limb ischemia, major amputation for vascular causes, myocardial infarction, ischemic stroke or cardiovascular death compared to aspirin alone while being safe?] Rev Med Interne. 2020 Aug 11;: Authors: Lanthier L, Huard G, Plourde ME, Cauchon M PMID: 32798088 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - August 18, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Multiple facets of ADA2 deficiency: Vasculitis, auto-inflammatory disease and immunodeficiency: A literature review of 135 cases from literature.
Authors: Fayand A, Sarrabay G, Belot A, Hentgen V, Kone-Paut I, Grateau G, Melki I, Georgin-Lavialle S Abstract Deficiency of adenosine deaminase 2 (DADA2) is a recently described auto-inflammatory disorder. It is an autosomal recessive inherited disease, caused by mutations in the ADA2 gene (formerly known as CECR1) encoding ADA2 enzyme. Besides its role in the purine metabolism, it has been postulated that ADA2 may act as a growth factor for endothelial cells and in the differenciation of monocytes. Thus, deficiency of ADA2 would lead to endothelial damage and a skewing of monocytes into M1 pro-inflammatory macro...
Source: Revue de Medecine Interne - December 25, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Influenza infection: An update for clinicians.
Authors: Blot M, Chavanet P, Piroth L Abstract Lower respiratory infections remain the deadliest communicable disease in the world. Influenza infections are particularly involved, whether intrinsically, or more frequently, by promoting bacterial infections and superinfections. The flu is also responsible for the decompensation of many comorbidities and could lead to some myocardial infarction and stroke. The effect of antiviral therapies is limited but preventives measures, such as vaccination, remain a major public health issue. The flu is a major challenge at all levels and all times, from vaccine prevention, to ...
Source: Revue de Medecine Interne - January 16, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Benefits and risks of oxygen therapy during acute medical illness: Just a matter of dose!
Authors: Allardet-Servent J, Sicard G, Metz V, Chiche L Abstract Oxygen therapy is used to reverse hypoxemia since more than a century. Current usage is broader and includes routine oxygen administration despite normoxemia which may result in prolonged periods of hyperoxemia. While systematic oxygen therapy was expected to be of benefit in some ischemic diseases such as stroke or acute myocardial infarction, recent randomised controlled trials (RCTs) have challenged this hypothesis by showing the absence of clinical improvement. Although oxygen is known to be toxic at high inspired oxygen fractions, a recent meta-a...
Source: Revue de Medecine Interne - May 7, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Direct oral anticoagulants: In which indications? Which one to prescribe? For or against their use in frail patients and in atypical cases? Which monitoring and management haemorrhage complications?
Authors: Hoffmann C, Leven C, Le Mao R, De Moreuil C, Lacut K Abstract Since their approval, the direct oral anticoagulants have been widely used in the management of venous thromboembolism, for stroke and systemic embolism prevention in non valvular atrial fibrillation, and in venous thromboembolism prophylaxis after surgical hip or knee replacement. Because they are easy to use, with oral fixed doses and no biological monitoring need, they are more and more prescribed. New indications are rising in cancer associated thrombosis in France beyond the 6 first months of treatment, and to prevent cardiovascular events ...
Source: Revue de Medecine Interne - July 19, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Transthyretin cardiac amyloidosis.
Authors: Eicher JC, Audia S, Damy T Abstract Transthyretin (TTR) cardiac amyloidosis results from the dissociation of the tetrameric, liver-synthetized transport protein, either because of a mutation (hereditary CA), or spontaneously due to ageing (wild type CA). Monomers self-associate into amyloid fibrils within the myocardium, causing heart failure, arrhythmias and conduction defects. This overlooked disease must be recognized in case of unexplained increased thickness of the myocardium, particularly in subjects of African descent, in patients with heart failure and preserved ejection fraction, and in those with...
Source: Revue de Medecine Interne - August 23, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Cerebral bleeding during a cryotherapy session: A case report.
CONCLUSION: We hypothesize that the whole-body cryotherapy was responsible for this stroke. PMID: 32994067 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - October 2, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Fabry disease: A review.
Authors: Michaud M, Mauhin W, Belmatoug N, Bedreddine N, Garnotel R, Catros F, Lidove O, Gaches F Abstract Fabry disease is the second most frequent lysosomal storage disorder. It is a X-linked genetic disease secondary to alpha-galactosidase A enzyme deficiency. This is a progressive and systemic disease that affects both males and females. Classical symptoms and organ involvements are acral pain crisis, cornea verticillata, hypertrophic cardiomyopathy, stroke and chronic kidney disease with proteinuria. Nevertheless, organ damages can be missing or pauci-symptomatic and other common symptoms are poorly recognised...
Source: Revue de Medecine Interne - November 13, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Cerebral venous thrombosis revealing neurosyphilis
CONCLUSION: Cerebral venous thrombosis in neurosyphilis is a poorly described entity. This case report confirms the status of great simulator of syphilis. In the context of its worldwide recrudescence, syphilis must be evoked in front of an unexplained neurological disorder.PMID:34863597 | DOI:10.1016/j.revmed.2021.11.001
Source: Revue de Medecine Interne - December 5, 2021 Category: Internal Medicine Authors: O Chol S Gallet L Bouillet G Besson H Kholi Source Type: research

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