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Variations and characteristics of the various clinical phenotypes in a cohort of Nigerian sickle cell patients
CONCLUSION: The prevalence of SLU, AVN, priapism, nephropathy and the other complications of SCD show some variations from other studies. This variation in the clinical parameters across different clinical phenotypes indicates an interplay between age, genetic and environmental factors.PMID:34493173 | DOI:10.1080/16078454.2021.1972242
Source: Hematology - September 8, 2021 Category: Hematology Authors: Augustine Duru Anazoeze Jude Madu Helen Okoye Charles Nonyelu Onochie Obodo Kelechi Okereke Kenechi Madu Source Type: research

Distribution of sickle cell disease and assessment of risk factors based on transcranial Doppler values in the Gulf region.
Conclusions: The study results show that far fewer patients with SCD in the Gulf have abnormal TCD findings than the internationally reported. Larger studies are needed to identify the factors underlying this observation. PMID: 31983291 [PubMed - in process]
Source: Hematology - January 29, 2020 Category: Hematology Tags: Hematology Source Type: research

β(S) globin gene haplotype and the stroke risk among Egyptian children with sickle cell disease.
CONCLUSION: This study provides a relevant contribution to our understanding of the anthropological and historical background of the population in Egypt where Benin haplotype is the commonest β(S) globin gene haplotype and homozygous Benin/Benin is associated with higher stroke risk than other haplotypes. PMID: 29157167 [PubMed - as supplied by publisher]
Source: Hematology - November 23, 2017 Category: Hematology Tags: Hematology Source Type: research

The role of rs1984112_G at CD36 gene in increasing reticulocyte level among sickle cell disease patients.
CONCLUSION: Our results are similar to those found in Portuguese population which reported the role of rs1984112_G in increasing reticulocyte level among SCD patients. Consequently, the rs1984112_G of CD36 could be considered as a reliable biomarker for predicting patients at high risk for vascular occlusions and thus, allows earlier and more effective therapeutic management. PMID: 27869039 [PubMed - as supplied by publisher]
Source: Hematology - November 23, 2016 Category: Hematology Tags: Hematology Source Type: research

A comparison of heart function and arrhythmia in clinically asymptomatic patients with beta thalassemia intermedia and beta thalassemia major.
CONCLUSION: Both atrial and ventricular arrhythmias were more common in the beta thalassemia major group. Higher end-diastolic volume and stroke volume were detected in the beta thalassemia intermedia group. Pulmonary acceleration time was lower in the beta thalassemia intermedia group, which can be an indicator of higher pulmonary pressure. PMID: 27650671 [PubMed - as supplied by publisher]
Source: Hematology - September 23, 2016 Category: Hematology Tags: Hematology Source Type: research

Complications of sickle cell anaemia in children in Northwestern Tanzania.
Conclusion Children with SCA receiving care in Tanzania are diagnosed late, hospitalized frequently, and have severe complications. Opportunities exist to improve care through wider access to screening and diagnosis as well as better coordination of comprehensive care. PMID: 26868490 [PubMed - as supplied by publisher]
Source: Hematology - February 14, 2016 Category: Hematology Tags: Hematology Source Type: research