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Specialty: Molecular Biology
Source: Molecular Medicine Reports
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Total 175 results found since Jan 2013.
Delayed administration of guanosine improves long ‑term functional recovery and enhances neurogenesis and angiogenesis in a mouse model of photothrombotic stroke.
Delayed administration of guanosine improves long‑term functional recovery and enhances neurogenesis and angiogenesis in a mouse model of photothrombotic stroke.
Mol Med Rep. 2017 Apr 27;:
Authors: Deng G, Qiu Z, Li D, Fang Y, Zhang S
Abstract
Guanosine (GUO) is neuroprotective when administered acutely for the treatment of cerebral ischemia. The aim of the present study was to investigate whether delayed administration of GUO improved long‑term functional recovery following stroke, as well as to explore the potential underlying mechanisms. GUO (8 mg/kg) or a vehicle was administered intraperitone...
Source: Molecular Medicine Reports - May 12, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Modulators of microglia activation and polarization in ischemic stroke (Review).
Authors: Jiang CT, Wu WF, Deng YH, Ge JW
Abstract
Ischemic stroke is one of the leading causes of mortality and disability worldwide. However, there is a current lack of effective therapies available. As the resident macrophages of the brain, microglia can monitor the microenvironment and initiate immune responses. In response to various brain injuries, such as ischemic stroke, microglia are activated and polarized into the proinflammatory M1 phenotype or the anti‑inflammatory M2 phenotype. The immunomodulatory molecules, such as cytokines and chemokines, generated by these microglia are closely associated with s...
Source: Molecular Medicine Reports - April 25, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Electroacupuncture promotes neural stem cell proliferation and neurogenesis in the dentate gyrus of rats following stroke via upregulation of Notch1 expression.
In conclusion, to the best of our knowledge, the present study was the first to demonstrate that EA treatment promoted NSC proliferation and neurogenesis in the DG area through the upregulation of Notch signaling following a stroke; therefore, EA may be a useful novel therapeutic strategy in future stroke treatment.
PMID: 26328605 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - September 4, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Temporal profiles of blood pressure, circulating nitric oxide, and adrenomedullin as predictors of clinical outcome in acute ischemic stroke patients.
Authors: Serrano-Ponz M, Rodrigo-Gasqué C, Siles E, Martínez-Lara E, Ochoa-Callejero L, Martínez A
Abstract
Stroke remains an important health and social challenge. The present study investigated whether blood pressure (BP) parameters and circulating levels of nitric oxide metabolites (NOx) and adrenomedullin (AM) may predict clinical outcomes of stroke. Patients (n=76) diagnosed with acute ischemic stroke were admitted to the stroke unit and clinical history data and monitored parameters were recorded. Blood plasma was collected at days 1, 2, and 7 to measure NOx and AM levels. Infarct volume, neurological sev...
Source: Molecular Medicine Reports - April 3, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Cryptotanshinone exhibits therapeutical effects on cerebral stroke through the PI3K/AKT ‑eNOS signaling pathway.
In conclusion, CPT exhibited a protective effect against cerebral stroke through inhibition of the PI3K/AKT‑eNOS signaling pathway. These results suggested the potential of CPT as a promising agent in the treatment of cerebral stroke.
PMID: 29152647 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - November 22, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Cocaine ‑ and amphetamine‑regulated transcript (CART) is associated with dopamine and is protective against ischemic stroke.
Cocaine‑ and amphetamine‑regulated transcript (CART) is associated with dopamine and is protective against ischemic stroke.
Mol Med Rep. 2018 Jul 19;:
Authors: Lin L, Sun D, Chang J, Ma M, Zhou X, Zhao M, Li J
Abstract
Cocaine and amphetamine‑regulated transcript (CART) is a neuropeptide that can protect brains against ischemic injury. The aim of the present study was to investigate the effects of the CART within ischemic stroke and it possible mechanism. The expression levels of dopamine (DA) and CART in ischemic brain tissues of mice were measured following middle cerebral artery occlusion (MCA...
Source: Molecular Medicine Reports - August 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Circulating mRNA and microRNA profiling analysis in patients with ischemic stroke.
Authors: Sun S, Li L, Dong L, Cheng J, Zhao C, Bao C, Wang H
Abstract
To provide insight into molecular diagnosis and individualized treatment of ischemic stroke (IS), several available datasets in IS were analyzed to identify the differentially expressed genes and microRNAs (miRNAs). Series matrix files from GSE22255 and GSE16561 (mRNA profiles), a well as GSE110993 (miRNA profile) were downloaded from the Gene Expression Omnibus database. System‑level clustering was performed with GeneCluster 3.0 software, and gene annotation and pathway enrichment were performed with gene ontology analysis and Database for Ann...
Source: Molecular Medicine Reports - July 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
MicroRNA-126/stromal cell-derived factor 1/C-X-C chemokine receptor type 7 signaling pathway promotes post-stroke angiogenesis of endothelial progenitor cell transplantation.
Authors: Shan C, Ma Y
Abstract
Stroke is the most common cause of mortality worldwide. Post-stroke angiogenesis is of great significance to the treatment of strokes. The aim of the present study was to investigate the mechanism underlying the angiogenesis-promoting effect of microRNA‑126 (miR‑126)‑associated signaling pathways using a stroke model in vivo and a cell migration model in vitro. Bone marrow‑derived endothelial progenitor cells (EPCs) were extracted and identified using a density gradient method. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was performed to examin...
Source: Molecular Medicine Reports - February 4, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke
In conclusion, this study contributes to the current understanding of the mechanisms of EphB4 in exerting neurorestorative effects and may recommend a potential new strategy for ischemic stroke treatment.PMID:34476505 | DOI:10.3892/mmr.2021.12396
Source: Molecular Medicine Reports - September 3, 2021 Category: Molecular Biology Authors: Jin Wang Zun Zhang Shaojing Fu Xiaojie Li Xinhui Li Shaobin Wang Lihe Yuan Source Type: research
Prehypertensive treatment with losartan, however not amlodipine, leads to long‑term effects on blood pressure and reduces the risk of stroke in spontaneously hypertensive stroke‑prone rats.
Authors: Zhang L, He D, Lin J
Abstract
The current study investigated the efficacy of losartan and amlodipine in protecting spontaneously hypertensive stroke‑prone (SHRSP) rats against the risk of stroke. SHRSP rats were administered losartan, amlodipine or the vehicle for 6 weeks. There were no significant differences in systolic blood pressure (SBP) in rats treated with losartan or amlodipine, however, following drug withdrawal, rats treated with losartan maintained reduced SBP for a longer time compared with rats treated with amlodipine. In addition, rats treated with losartan exhibited thinner vascular walls...
Source: Molecular Medicine Reports - December 11, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model.
Authors: Chen F, Li H, Zhu G, Chen X, Tang Z
Abstract
The aim of the present study was to investigate the effects of sodium tanshinone IIA sulfonate (STS) on inflammatory responses, aortic endothelial cell apoptosis, disseminated intravascular coagulation (DIC) and multiple organ damage in an animal model of classic heat stroke (CHS). The rats in the heat stroke (HS) and STS‑treated heat stroke (STS‑HS) groups were placed into a pre‑warmed animal temperature controller (ATC) at 35˚C. The moment at which the rectal temperature reached 43.5˚C was considered as the time of onset of HS. In the HS groups, the ra...
Source: Molecular Medicine Reports - May 13, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
mTOR is involved in stroke-induced seizures and the anti-seizure effect of mild hypothermia.
Authors: Yang GS, Zhou XY, An XF, Liu XJ, Zhang YJ, Yu D
Abstract
Stroke is considered an underlying etiology of the development of seizures. Stroke leads to glucose and oxygen deficiency in neurons, resulting in brain dysfunction and injury. Mild hypothermia is a therapeutic strategy to inhibit stroke‑induced seizures, which may be associated with the regulation of energy metabolism of the brain. Mammalian target of rapamycin (mTOR) signaling and solute carrier family 2, facilitated glucose transporter member (GLUT)‑1 are critical for energy metabolism. Furthermore, mTOR overactivation and GLUT‑1 deficiency...
Source: Molecular Medicine Reports - February 28, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Intracarotid cold saline infusion contributes to neuroprotection in MCAO ‑induced ischemic stroke in rats via serum and glucocorticoid‑regulated kinase 1.
Intracarotid cold saline infusion contributes to neuroprotection in MCAO‑induced ischemic stroke in rats via serum and glucocorticoid‑regulated kinase 1.
Mol Med Rep. 2019 Aug 21;:
Authors: Wang D, Huang Z, Li L, Yuan Y, Xiang L, Wu X, Ni C, Yu W
Abstract
Intracarotid cold saline infusion (ICSI) brings about neuroprotective effects in ischemic stroke. However, the involvement of serum and glucocorticoid‑regulated kinase 1 (SGK1) in the underlying mechanism of ICSI is not fully understood; therefore, we used the rat middle cerebral artery occlusion (MCAO) model to investigate the neuroprotective ...
Source: Molecular Medicine Reports - September 7, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Protective multi ‑target effects of DL‑3‑n‑butylphthalide combined with 3‑methyl‑1‑phenyl‑2‑pyrazolin‑5‑one in mice with ischemic stroke
In conclusion, the results of the present study demonstrated that NBP and edaravone effectively prevented ischemic stroke damage with multi‑target protective effects. In addition, NBP + edaravone may be a promising combination therapy for ischemic stroke.PMID:34643246 | DOI:10.3892/mmr.2021.12490
Source: Molecular Medicine Reports - October 13, 2021 Category: Molecular Biology Authors: Yali Guan Pengfei Li Yingshuo Liu Lan Guo Qingwen Wu Yuefa Cheng Source Type: research
