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Source: Oncology Letters
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Total 421 results found since Jan 2013.
Statin use improves the prognosis of ovarian cancer: An updated and comprehensive meta-analysis
Oncol Lett. 2022 Dec 23;25(2):65. doi: 10.3892/ol.2022.13648. eCollection 2023 Feb.ABSTRACTStatins are lipid-lowering agents that have also been found to have anticancer effects. The relationship between statin use and clinical outcomes in ovarian cancer (OC) remains controversial, as previous assessments of the relationship between statin use and OC prognosis have yielded inconsistent results. Therefore, a comprehensive meta-analysis was performed in the present study to investigate this association. Studies were systematically retrieved by searching the PubMed, Embase and Cochrane Library databases, and consulting refere...
Source: Oncology Letters - January 16, 2023 Category: Cancer & Oncology Authors: Qingxue Wang Zheng Zhi Hua Han Qingtao Zhao Xing Wang Shumin Cao Jing Zhao Source Type: research
Side effects of tyrosine kinase inhibitors therapy in patients with non-small cell lung cancer and associations with < em > EGFR < /em > polymorphisms: A systematic review and meta-analysis
Oncol Lett. 2022 Dec 23;25(2):62. doi: 10.3892/ol.2022.13649. eCollection 2023 Feb.ABSTRACTRash and diarrhea are common side effects of tyrosine kinase inhibitor (TKI) therapy administered to patients with non-small cell lung cancer (NSCLC). The polymorphisms of the epidermal growth factor receptor (EGFR) gene may be a potential predictor of these side effects. The aim of the present meta-analysis was to examine the association of EGFR polymorphisms and TKI-associated toxicities. Electronic databases (PubMed, Scopus and ISI Web of Science) were searched for relevant studies. According to the inclusion and exclusion criteri...
Source: Oncology Letters - January 16, 2023 Category: Cancer & Oncology Authors: Jasmina Obradovic Jovana Todosijevic Vladimir Jurisic Source Type: research
Connexin 43 overexpression induces lung cancer angiogenesis < em > in vitro < /em > following phosphorylation at Ser279 in its C-terminus
Oncol Lett. 2022 Jul 5;24(3):293. doi: 10.3892/ol.2022.13413. eCollection 2022 Sep.ABSTRACTBlocking angiogenesis can inhibit tumor growth and metastasis. However, the mechanism underlying regulation of lung cancer angiogenesis remains unclear. The gap junction protein connexin 43 (Cx43) is implicated in angiogenesis. The aim of the present study was to determine the role of Cx43 in angiogenesis in vitro and its signaling pathways. Human pulmonary microvascular endothelial cells were transfected with Cx43-targeting siRNA or Cx43-overexpressing recombinant plasmid vector. Reverse transcription-quantitative polymerase chain r...
Source: Oncology Letters - August 11, 2022 Category: Cancer & Oncology Authors: Zizi Zhou Wenxiang Chai Yi Liu Yao Liu Huiyu Pan Qiang Wu Xiaoming Zhang Source Type: research
miR-let-7c-3p targeting on Egr-1 contributes to the committed differentiation of leukemia cells into monocyte/macrophages
In conclusion, miR-let-7c-3p could bind to the 3'UTR of Egr-1 and negatively regulated Egr-1 expression. The miR-let-7c-3p/Egr-1 signaling axis was closely associated with the committed differentiation of K562 cells from leukemia cells to monocytes/macrophages.PMID:35782903 | PMC:PMC9247672 | DOI:10.3892/ol.2022.13393
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Fu Qi Xinping Wang Shouzhen Zhao Chaozhe Wang Ruijing Sun Huan Wang Pengchao Du Jing Wang Xidi Wang Guosheng Jiang Source Type: research
Polo-like kinase 4 is associated with advanced TNM stages and reduced survival and its inhibition improves chemosensitivity in colorectal cancer
In conclusion, the high expression of tumor PLK4 was associated with advanced TNM stage and shorter OS in patients with CRC. In addition, targeting PLK4 improved chemosensitivity in CRC cells.PMID:35782899 | PMC:PMC9247664 | DOI:10.3892/ol.2022.13389
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Zhengang Duan Lei Cai Jin Cao Wei Wu Source Type: research
miR-let-7c-3p targeting on Egr-1 contributes to the committed differentiation of leukemia cells into monocyte/macrophages
In conclusion, miR-let-7c-3p could bind to the 3'UTR of Egr-1 and negatively regulated Egr-1 expression. The miR-let-7c-3p/Egr-1 signaling axis was closely associated with the committed differentiation of K562 cells from leukemia cells to monocytes/macrophages.PMID:35782903 | PMC:PMC9247672 | DOI:10.3892/ol.2022.13393
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Fu Qi Xinping Wang Shouzhen Zhao Chaozhe Wang Ruijing Sun Huan Wang Pengchao Du Jing Wang Xidi Wang Guosheng Jiang Source Type: research
Polo-like kinase 4 is associated with advanced TNM stages and reduced survival and its inhibition improves chemosensitivity in colorectal cancer
In conclusion, the high expression of tumor PLK4 was associated with advanced TNM stage and shorter OS in patients with CRC. In addition, targeting PLK4 improved chemosensitivity in CRC cells.PMID:35782899 | PMC:PMC9247664 | DOI:10.3892/ol.2022.13389
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Zhengang Duan Lei Cai Jin Cao Wei Wu Source Type: research
miR-let-7c-3p targeting on Egr-1 contributes to the committed differentiation of leukemia cells into monocyte/macrophages
In conclusion, miR-let-7c-3p could bind to the 3'UTR of Egr-1 and negatively regulated Egr-1 expression. The miR-let-7c-3p/Egr-1 signaling axis was closely associated with the committed differentiation of K562 cells from leukemia cells to monocytes/macrophages.PMID:35782903 | PMC:PMC9247672 | DOI:10.3892/ol.2022.13393
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Fu Qi Xinping Wang Shouzhen Zhao Chaozhe Wang Ruijing Sun Huan Wang Pengchao Du Jing Wang Xidi Wang Guosheng Jiang Source Type: research
Polo-like kinase 4 is associated with advanced TNM stages and reduced survival and its inhibition improves chemosensitivity in colorectal cancer
In conclusion, the high expression of tumor PLK4 was associated with advanced TNM stage and shorter OS in patients with CRC. In addition, targeting PLK4 improved chemosensitivity in CRC cells.PMID:35782899 | PMC:PMC9247664 | DOI:10.3892/ol.2022.13389
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Zhengang Duan Lei Cai Jin Cao Wei Wu Source Type: research
miR-let-7c-3p targeting on Egr-1 contributes to the committed differentiation of leukemia cells into monocyte/macrophages
In conclusion, miR-let-7c-3p could bind to the 3'UTR of Egr-1 and negatively regulated Egr-1 expression. The miR-let-7c-3p/Egr-1 signaling axis was closely associated with the committed differentiation of K562 cells from leukemia cells to monocytes/macrophages.PMID:35782903 | PMC:PMC9247672 | DOI:10.3892/ol.2022.13393
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Fu Qi Xinping Wang Shouzhen Zhao Chaozhe Wang Ruijing Sun Huan Wang Pengchao Du Jing Wang Xidi Wang Guosheng Jiang Source Type: research
Polo-like kinase 4 is associated with advanced TNM stages and reduced survival and its inhibition improves chemosensitivity in colorectal cancer
In conclusion, the high expression of tumor PLK4 was associated with advanced TNM stage and shorter OS in patients with CRC. In addition, targeting PLK4 improved chemosensitivity in CRC cells.PMID:35782899 | PMC:PMC9247664 | DOI:10.3892/ol.2022.13389
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Zhengang Duan Lei Cai Jin Cao Wei Wu Source Type: research
miR-let-7c-3p targeting on Egr-1 contributes to the committed differentiation of leukemia cells into monocyte/macrophages
In conclusion, miR-let-7c-3p could bind to the 3'UTR of Egr-1 and negatively regulated Egr-1 expression. The miR-let-7c-3p/Egr-1 signaling axis was closely associated with the committed differentiation of K562 cells from leukemia cells to monocytes/macrophages.PMID:35782903 | PMC:PMC9247672 | DOI:10.3892/ol.2022.13393
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Fu Qi Xinping Wang Shouzhen Zhao Chaozhe Wang Ruijing Sun Huan Wang Pengchao Du Jing Wang Xidi Wang Guosheng Jiang Source Type: research
