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Source: Comprehensive Physiology
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Vasculopathy in Sickle Cell Disease: From Red Blood Cell Sickling to Vascular Dysfunction
Compr Physiol. 2021 Apr 1;11(2):1785-1803. doi: 10.1002/cphy.c200024.ABSTRACTSickle cell disease (SCD) is a hereditary disorder that leads to the production of an abnormal hemoglobin, hemoglobin S (HbS). HbS polymerizes in deoxygenated conditions, which can prompt red blood cell (RBC) sickling and leaves the RBCs more rigid, fragile, and prone to hemolysis. SCD patients suffer from a plethora of complications, ranging from acute complications, such as characteristic, frequent, and debilitating vaso-occlusive episodes to chronic organ damage. While RBC sickling is the primary event at the origin of vaso-occlusive processes,...
Source: Comprehensive Physiology - April 1, 2021 Category: Physiology Authors: Elie Nader Nicola Conran Marc Romana Philippe Connes Source Type: research
