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Total 1090 results found since Jan 2013.

Molecules, Vol. 28, Pages 2412: LncRNA JHDM1D-AS1 Is a Key Biomarker for Progression and Modulation of Gemcitabine Sensitivity in Bladder Cancer Cells
o Salvadori Long non-coding RNAs are frequently found to be dysregulated and are linked to carcinogenesis, aggressiveness, and chemoresistance in a variety of tumors. As expression levels of the JHDM1D gene and lncRNA JHDM1D-AS1 are altered in bladder tumors, we sought to use their combined expression to distinguish between low-and high-grade bladder tumors by RTq-PCR. In addition, we evaluated the functional role of JHDM1D-AS1 and its association with the modulation of gemcitabine sensitivity in high-grade bladder-tumor cells. J82 and UM-UC-3 cells were treated with siRNA-JHDM1D-AS1 and/or three concentrations of gemc...
Source: Molecules - March 6, 2023 Category: Chemistry Authors: Isadora Oliveira Ansaloni Pereira Glenda Nicioli da Silva Tamires Cunha Almeida Ana Paula Braga Lima Andr é Luiz Ventura Sávio Katia Ramos Moreira Leite Daisy Maria F ávero Salvadori Tags: Article Source Type: research

Molecules, Vol. 28, Pages 2361: Chemistry and Bioactivity of Croton Essential Oils: Literature Survey and Croton hirtus from Vietnam
William N. Setzer Using essential oils to control vectors, intermediate hosts, and disease-causing microorganisms is a promising approach. The genus Croton in the family Euphorbiaceae is a large genus, with many species containing large amounts of essential oils, however, essential oil studies are limited in terms of the number of Croton species investigated. In this work, the aerial parts of C. hirtus growing wild in Vietnam were collected and analyzed by gas chromatography/mass spectrometry (GC/MS). A total of 141 compounds were identified in C. hirtus essential oil, in which sesquiterpenoids dominated, comprising ...
Source: Molecules - March 3, 2023 Category: Chemistry Authors: Ngoc Anh Luu-dam Canh Viet Cuong Le Prabodh Satyal Thi Mai Hoa Le Van Huong Bui Van Hoa Vo Gia Huy Ngo Thi Chinh Bui Huy Hung Nguyen William N. Setzer Tags: Article Source Type: research

Molecules, Vol. 28, Pages 2356: Computational Design, Synthesis, and Biophysical Evaluation of & beta;-Amido Boronic Acids as SARS-CoV-2 Mpro Inhibitors
Molecules, Vol. 28, Pages 2356: Computational Design, Synthesis, and Biophysical Evaluation of β-Amido Boronic Acids as SARS-CoV-2 Mpro Inhibitors Molecules doi: 10.3390/molecules28052356 Authors: Enrico M. A. Fassi Marco Manenti Andrea Citarella Michele Dei Cas Sara Casati Nicola Micale Tanja Schirmeister Gabriella Roda Alessandra Silvani Giovanni Grazioso The COVID-19 pandemic has given a strong impetus to the search for antivirals active on SARS-associated coronaviruses. Over these years, numerous vaccines have been developed and many of these are effective and clinically available. Si...
Source: Molecules - March 3, 2023 Category: Chemistry Authors: Enrico M. A. Fassi Marco Manenti Andrea Citarella Michele Dei Cas Sara Casati Nicola Micale Tanja Schirmeister Gabriella Roda Alessandra Silvani Giovanni Grazioso Tags: Article Source Type: research

Molecules, Vol. 28, Pages 2333: Triterpene Derivatives as Potential Inhibitors of the RBD Spike Protein from SARS-CoV-2: An In Silico Approach
orales The appearance of a new coronavirus, SARS-CoV-2, in 2019 kicked off an international public health emergency. Although rapid progress in vaccination has reduced the number of deaths, the development of alternative treatments to overcome the disease is still necessary. It is known that the infection begins with the interaction of the spike glycoprotein (at the virus surface) and the angiotensin-converting enzyme 2 cell receptor (ACE2). Therefore, a straightforward solution for promoting virus inhibition seems to be the search for molecules capable of abolishing such attachment. In this work, we tested 18 triterpe...
Source: Molecules - March 2, 2023 Category: Chemistry Authors: Mayra Avelar Laura Pedraza-Gonz ález Adalgisa Sinicropi Virginia Flores-Morales Tags: Article Source Type: research

Molecules, Vol. 28, Pages 2319: Design and Synthesis of New Acyl Urea Analogs as Potential & sigma;1R Selective Ligands
Molecules, Vol. 28, Pages 2319: Design and Synthesis of New Acyl Urea Analogs as Potential σ1R Selective Ligands Molecules doi: 10.3390/molecules28052319 Authors: Rajesh Thapa Rafael Flores Kwan H. Cheng Bereket Mochona Donald Sikazwe In search of synthetically accessible open-chain analogs of PD144418 or 5-(1-propyl-1,2,5,6-tetrahydropyridin-3-yl)-3-(p-tolyl)isoxazole, a highly potent sigma-1 receptor (σ1R) ligand, we herein report the design and synthesis of sixteen arylated acyl urea derivatives. Design aspects included modeling the target compounds for drug-likeness, docking at &...
Source: Molecules - March 2, 2023 Category: Chemistry Authors: Rajesh Thapa Rafael Flores Kwan H. Cheng Bereket Mochona Donald Sikazwe Tags: Article Source Type: research

Molecules, Vol. 28, Pages 2236: Lipopolysaccharide Activating NF-kB Signaling by Regulates HTRA1 Expression in Human Retinal Pigment Epithelial Cells
glin Yang Inflammation and elevated expression of high temperature requirement A serine peptidase 1 (HTRA1) are known high risk factors for age-related macular degeneration (AMD). However, the specific mechanism that HTRA1 causes AMD and the relationship between HTRA1 and inflammation remains unclear. We found that lipopolysaccharide (LPS) induced inflammation enhanced the expression of HTRA1, NF-κB, and p-p65 in ARPE-19 cells. Overexpression of HTRA1 up-regulated NF-κB expression, and on the other hand knockdown of HTRA1 down-regulated the expression of NF-κB. Moreover, NF-&am...
Source: Molecules - February 28, 2023 Category: Chemistry Authors: Shengliu Pan Min Liu Huijuan Xu Junlan Chuan Zhenglin Yang Tags: Article Source Type: research

Molecules, Vol. 28, Pages 2191: Potential of siRNA-Bearing Subtilosomes in the Treatment of Diethylnitrosamine-Induced Hepatocellular Carcinoma
grawal Mohammad Owais Therapeutics, based on small interfering RNA (siRNA), have demonstrated tremendous potential for treating cancer. However, issues such as non-specific targeting, premature degradation, and the intrinsic toxicity of the siRNA, have to be solved before they are ready for use in translational medicines. To address these challenges, nanotechnology-based tools might help to shield siRNA and ensure its specific delivery to the target site. Besides playing a crucial role in prostaglandin synthesis, the cyclo-oxygenase-2 (COX-2) enzyme has been reported to mediate carcinogenesis in various types of canc...
Source: Molecules - February 27, 2023 Category: Chemistry Authors: Fauzia Jamal Ghufran Ahmed Mohammad Farazuddin Ishrat Altaf Saba Farheen Qamar Zia Asim Azhar Hira Ahmad Aijaz Ahmed Khan Satyanarayana Somavarapu Anshu Agrawal Mohammad Owais Tags: Article Source Type: research

Molecules, Vol. 28, Pages 2118: Potential Anti-SARS-CoV-2 Molecular Strategies
llo Finding effective antiviral molecular strategies was a main concern in the scientific community when the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of 2019 as an easily transmissible and potentially deadly β-coronavirus able to cause the coronavirus disease 19 (COVID-19), which famously led to one of the most worrying pandemics in recent times. Other members of this zoonotic pathogenic family were already known before 2019, but apart from the SARS-CoV, which was responsible of severe acute respiratory syndrome (SARS) pandemic in 2002/2003, and Middle East respirator...
Source: Molecules - February 24, 2023 Category: Chemistry Authors: Caterina Vicidomini Giovanni N. Roviello Tags: Editorial Source Type: research

Molecules, Vol. 28, Pages 2062: Relationships between Molecular Characteristics of Novel Organic Selenium Compounds and the Formation of Sulfur Compounds in Selenium Biofortified Kale Sprouts
This study supported the conclusion that future biofortifiers composed of organic compounds should simultaneously contain nitryl groups, which may facilitate the production of plant-based sulfur compounds, as well as organoselenium moieties, which may influence the production of low molecular weight selenium metabolites. In the case of the new chemical compounds, environmental aspects should also be evaluated.
Source: Molecules - February 22, 2023 Category: Chemistry Authors: Pawe ł Zagrodzki Agnieszka Wiesner Monika Marcinkowska Marek Jamrozik Enrique Dom ínguez-Álvarez Katarzyna Bier ła Ryszard Łobiński Joanna Szpunar Jadwiga Handzlik Agnieszka Galanty Shela Gorinstein Pawe ł Paśko Tags: Article Source Type: research

Molecules, Vol. 28, Pages 2074: Rhein & ndash;Amino Acid Ester Conjugates as Potential Antifungal Agents: Synthesis and Biological Evaluation
In this study, a series of rhein–amino acid ester conjugates were designed and synthesized in good yields, and their structures were confirmed by 1H-NMR, 13C-NMR and HRMS. The bioassay results revealed that most of the conjugates exhibited potent inhibitory activity against R. solani and S. sclerotiorum. In particular, conjugate 3c had the highest antifungal activity against R. solani with an EC50 value of 0.125 mM. For S. sclerotiorum, conjugate 3m showed the highest antifungal activity with an EC50 value of 0.114 mM. Satisfactorily, conjugate 3c exhibited better protective effects than that of the positive ...
Source: Molecules - February 22, 2023 Category: Chemistry Authors: Shunshun Chen Meimei Wang Linhua Yu Jinchao Shi Yong Zhang Yao Tian Li Li Xiang Zhu Junkai Li Tags: Article Source Type: research

Molecules, Vol. 28, Pages 2014: Proteomics Analysis of Lymphoblastoid Cell Lines from Patients with Amyotrophic Lateral Sclerosis
an Radu Amyotrophic lateral sclerosis (ALS) consists of the progressive degeneration of motor neurons, caused by poorly understood mechanisms for which there is no cure. Some of the cellular perturbations associated with ALS can be detected in peripheral cells, including lymphocytes from blood. A related cell system that is very suitable for research consists of human lymphoblastoid cell lines (LCLs), which are immortalized lymphocytes. LCLs that can be easily expanded in culture and can be maintained for long periods as stable cultures. We investigated, on a small set of LCLs, if a proteomics analysis using liquid chr...
Source: Molecules - February 21, 2023 Category: Chemistry Authors: Danielle Whitham Eugene Belenkiy Costel C. Darie Aurelian Radu Tags: Article Source Type: research

Molecules, Vol. 28, Pages 1972: Anti-Cancer Effects of Queen Bee Acid (10-Hydroxy-2-Decenoic Acid) and Its Cellular Mechanisms against Human Hepatoma Cells
Conclusion: The current results confirmed the potent in vitro cytotoxic effects of 10-HDA on HepG2 cells with no significant cytotoxic effects on normal cells. Although its mechanisms of action have not been fully studied, the induction of apoptosis via different pathways was determined as one of the principle mechanisms of action of 10-HDA against HepG2 cells. Nevertheless, additional surveys must be performed to clearly understand the mechanisms of action and safety of this fatty acid.
Source: Molecules - February 19, 2023 Category: Chemistry Authors: Zafer Saad Al Shehri Abdullah D. Alanazi Sultan F. Alnomasy Tags: Article Source Type: research

Molecules, Vol. 28, Pages 1959: Recent Trends in the Development of Novel Metal-Based Antineoplastic Drugs
ova Since the accidental discovery of the anticancer properties of cisplatin more than half a century ago, significant efforts by the broad scientific community have been and are currently being invested into the search for metal complexes with antitumor activity. Coordination compounds of transition metals such as platinum (Pt), ruthenium (Ru) and gold (Au) have proven their effectiveness as diagnostic and/or antiproliferative agents. In recent years, experimental work on the potential applications of elements including lanthanum (La) and the post-transition metal gallium (Ga) in the field of oncology has been gaining...
Source: Molecules - February 18, 2023 Category: Chemistry Authors: Lozan Todorov Irena Kostova Tags: Review Source Type: research

Molecules, Vol. 28, Pages 1955: Gallium(III)- and Indium(III)-Containing Ionic Liquids as Highly Active Catalysts in Organic Synthesis
ok The chemical industry still requires development of environmentally friendly processes. Acid-catalysed chemical processes may cause environmental problems. Urgent need to replace conventional acids has forced the search for sustainable alternatives. Metal-containing ionic liquids have drawn considerable attention from scientists for many years. These compounds may exhibit very high Lewis acidity, which is usually dependent on the composition of the ionic liquid with the particular content of metal salt. Therefore, metal-containing ionic liquids have found a lot of applications and are successfully employed as cataly...
Source: Molecules - February 18, 2023 Category: Chemistry Authors: Justyna Wi ęcławik Anna Chrobok Tags: Review Source Type: research

Molecules, Vol. 28, Pages 1874: Berberine Ameliorates Metabolic-Associated Fatty Liver Disease Mediated Metabolism Disorder and Redox Homeostasis by Upregulating Clock Genes: Clock and Bmal1 Expressions
Shijian Quan Metabolic-associated fatty liver disease (MAFLD) is one of the most common chronic liver diseases, which in turn triggers mild inflammation, metabolic dysfunction, fibrosis, and even cancer. Accumulating evidence has suggested that Berberine (BBR) could significantly improve MAFLD progression. Clock and Bmal1 as heterodimer proteins highly participated in the development of MAFLD, but whether BBR targets Clock and Bmal1 in MAFLD remains poorly understood. The result suggested that the protein levels of Clock and Bmal1 were decreased in MAFLD mice, which was negatively correlated with elevated reactive o...
Source: Molecules - February 16, 2023 Category: Chemistry Authors: Cunsi Ye Yajing Zhang Shaomin Lin Yi Chen Zimiao Wang Haoyinghua Feng Guangqing Fang Shijian Quan Tags: Article Source Type: research