Filtered By:
Source: Molecules

This page shows you your search results in order of relevance. This is page number 9.

Order by Relevance | Date

Total 1090 results found since Jan 2013.

Molecules, Vol. 22, Pages 276: Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase
Ginkgolic acid C 17:1 (GAC 17:1) extracted from Ginkgo biloba leaves, has been previously reported to exhibit diverse antitumor effect(s) through modulation of several molecular targets in tumor cells, however the detailed mechanism(s) of its actions still remains to be elucidated. Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor that regulates various critical functions involved in progression of diverse hematological malignancies, including multiple myeloma, therefore attenuating STAT3 activation may have a potential in cancer therapy. We determined the anti-tumor mechanism ...
Source: Molecules - February 12, 2017 Category: Chemistry Authors: Seung Baek Jong Lee Chulwon Kim Jeong-Hyeon Ko Seung-Hee Ryu Seok-Geun Lee Woong Yang Jae-Young Um Arunachalam Chinnathambi Sulaiman Alharbi Gautam Sethi Kwang Ahn Tags: Article Source Type: research

Molecules, Vol. 22, Pages 612: c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells
In this study, we explored the control of expr ession of GNA12 in prostate cancer cells. Initial studies on LnCAP (low metastatic potential, containing low levels of GNA12) and PC3 (high metastatic potential, containing high GNA12 levels) cells revealed that GNA12 mRNA levels correlated with protein levels, suggesting control at the transcriptio nal level. To identify potential factors controlling GNA12 transcription, we cloned the upstream 5′ regulatory region of the human GNA12 gene and examined its activity using reporter assays. Deletion analysis revealed the highest level of promoter activity in a 784 bp region, and...
Source: Molecules - April 10, 2017 Category: Chemistry Authors: Udhaya Udayappan Patrick Casey Tags: Article Source Type: research

Molecules, Vol. 22, Pages 745: Modulation of HO-1 by Ferulic Acid Attenuates Adipocyte Differentiation in 3T3-L1 Cells
Ferulic acid (FA) is phenolic compound found in fruits. Many studies have reported that FA has diverse therapeutic effects against metabolic diseases. However, the mechanism by which FA modulates adipogenesis via the expression of heme oxygenase-1 (HO-1) implicated in suppression of adipocyte differentiation is not fully understood. We investigated whether HO-1 can be activated by FA and suppress adipogenic factors in 3T3-L1. Our results showed that FA suppresses triglyceride-synthesizing enzymes, fatty acid synthase (FASN) and acetyl-CoA carboxylase (ACC). We observed that the expression of CCAAT/enhancer binding protein ...
Source: Molecules - May 5, 2017 Category: Chemistry Authors: Eun-Jeong Koh Kui-Jin Kim Young-Jin Seo Jia Choi Boo-Yong Lee Tags: Article Source Type: research

Molecules, Vol. 22, Pages 782: Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications
Nucleic acids, including DNA, microRNA (miRNA), small interfering RNA (siRNA), and antisense oligonucleotide (ASO), are powerful gene regulators, which have been demonstrated as promising drug candidates for therapeutic treatments. Nevertheless, poor cellular membrane permeability and serum stability have greatly hindered the applications of nucleic acids in biomedicine. To address these issues, associate carriers that can encapsulate and protect nucleic acids are urgently required. Mesoporous silica nanoparticles (MSNs or MSNPs), which are nanomaterials with excellent biocompatibility, large surface area for functionaliza...
Source: Molecules - May 11, 2017 Category: Chemistry Authors: Wenzhang Cha Rengen Fan Yufeng Miao Yong Zhou Chenglin Qin Xiangxiang Shan Xinqiang Wan Jinbo Li Tags: Review Source Type: research

Molecules, Vol. 22, Pages 892: The Cytotoxicity of the Ajoene Analogue BisPMB in WHCO1 Oesophageal Cancer Cells Is Mediated by CHOP/GADD153
Garlic is a food and medicinal plant that has been used in folk medicine since ancient times for its beneficial health effects, which include protection against cancer. Crushed garlic cloves contain an array of small sulfur-rich compounds such as ajoene. Ajoene is able to interfere with biological processes and is cytotoxic to cancer cells in the low micromolar range. BisPMB is a synthetic ajoene analogue that has been shown in our laboratory to have superior cytotoxicity to ajoene. In the current study we have performed a DNA microarray analysis of bisPMB-treated WHCO1 oesophageal cancer cells to identify pathways and pro...
Source: Molecules - May 28, 2017 Category: Chemistry Authors: Vuyolwethu Siyo Georgia Sch äfer Roger Hunter Andriy Grafov Iryna Grafova Martin Nieger Arieh A. Katz M. Iqbal Parker Catherine H. Kaschula Tags: Article Source Type: research

Molecules, Vol. 22, Pages 1724: Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation
nguang Zhou Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA) and antisense oligonucleotides, are promising therapeutic agents. However, their low membrane permeability and sensitivity to nucleases present challenges to in vivo delivery. Chemical modifications of the ON offer a potential solution to improve the stability and efficacy of ON drugs. Combined with nanoparticle encapsulation, delivery at the site of action and gene silencing activity of chemically modified ON drugs can be further enhanced. In the present review, several types of ON drugs, selection of chemical modificatio...
Source: Molecules - October 13, 2017 Category: Chemistry Authors: Yating Sun Yarong Zhao Xiuting Zhao Robert J. Lee Lesheng Teng Chenguang Zhou Tags: Review Source Type: research

Molecules, Vol. 23, Pages 478: Phycocyanin Protects Against UVB-induced Apoptosis Through the PKC α/βII-Nrf-2/HO-1 Dependent Pathway in Human Primary Skin Cells
ok Chae Phycocyanin (Pc) is one of the active pigment constituents of Spirulina microalgae. It has been used for its potent antioxidant and anti-inflammatory properties. However, the protective effects of Pc against ultraviolet-B (UVB)-induced primary skin cells damage are still undefined. In the present study, we investigated whether Pc prevented UVB-induced apoptotic cell death in human dermal fibroblasts (HDF) and human epidermal keratinocytes (HEK). Pc induced the transcription of heme oxygenase-1 (HO-1). Furthermore, Pc treatments resulted in a marked increase in nuclear factor erythroid-derived 2 (NF-E2)-like 2 (...
Source: Molecules - February 22, 2018 Category: Chemistry Authors: Ki Mo Kim Joo Young Lee A-Rang Im Sungwook Chae Tags: Article Source Type: research

Molecules, Vol. 23, Pages 1614: Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression
k Taeg Kyu Kwon Garcinol is a polyisoprenylated benzophenone derived from the Garcinia indica fruit that possess potential therapeutic effects such as inhibition of inflammation and tumor expansion. Here, we investigated whether garcinol induces TRAIL sensitization in renal carcinoma cells. Single treatment with garcinol or TRAIL did not effect on apoptosis. However, combined treatment with garcinol plus TRAIL significantly induced apoptosis in renal carcinoma (Caki, ACHN and A498), lung carcinoma (A549), and hepatoma (SK-Hep1) cells. In contrast, garcinol plus TRAIL did not alter cell viability in normal cells. Garc...
Source: Molecules - July 2, 2018 Category: Chemistry Authors: Seok Kim Seung Un Seo Kyoung-Jin Min Seon Min Woo Ju-Ock Nam Peter Kubatka Shin Kim Jong-Wook Park Taeg Kyu Kwon Tags: Article Source Type: research

Molecules, Vol. 23, Pages 2264: Involvement of Up-Regulation of DR5 Expression and Down-Regulation of c-FLIP in Niclosamide-Mediated TRAIL Sensitization in Human Renal Carcinoma Caki Cells
eg Kyu Kwon Niclosamide is used to treat intestinal parasite infections, as being an anthelmintic drug. Recently, several papers suggest the niclosamide inhibits multiple signaling pathways, which are highly activated and mutated in cancer. Here, niclosamide was evaluated for identifying strategies to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance. Although niclosamide (100–200 nM) alone did not bring about cell death, combinations of niclosamide and TRAIL led to apoptotic cell death in carcinoma cells, but not in normal cells. Niclosamide markedly increased DR5 protei...
Source: Molecules - September 5, 2018 Category: Chemistry Authors: Jeong Mi Yun Seon Min Woo Seung Un Seo Kyoung-Jin Min Dong Eun Kim Taeg Kyu Kwon Tags: Article Source Type: research

Molecules, Vol. 23, Pages 2327: Resveratrol Suppresses Matrix Metalloproteinase-2 Activation Induced by Lipopolysaccharide in Mouse Osteoblasts via Interactions with AMP-Activated Protein Kinase and Suppressor of Cytokine Signaling 1
Lihong Qiu Porphyromonas endodontalis (P. endodontalis) lipopolysaccharide (LPS) is associated with the progression of bone resorption in periodontal and periapical diseases. Matrix metalloproteinase-2 (MMP-2) expression and activity are elevated in apical periodontitis and have been suggested to participate in bone resorption. Therefore, inhibiting MMP-2 activation may be considered a therapeutic strategy for treating apical periodontitis. Resveratrol is a natural non-flavonoid polyphenol that has been reported to have antioxidant, anti-cancer, and anti-inflammatory properties. However, the capacity of resveratrol ...
Source: Molecules - September 12, 2018 Category: Chemistry Authors: Yaqiong Yu Xiaolin Li Jing Mi Liu Qu Di Yang Jiajie Guo Lihong Qiu Tags: Article Source Type: research

Molecules, Vol. 23, Pages 2755: HSP70 Acetylation Prevents Combined mTORC1/2 Inhibitor and Curcumin Treatment-Induced Apoptosis
Kyu Kwon We previously reported that PP242 (dual inhibitor of mTORC1/2) plus curcumin induced apoptotic cell death through lysosomal membrane permeabilization (LMP)-mediated autophagy. However, the relationship between ER stress and apoptotic cell death by combined PP242 and curcumin treatment remains unknown. In the present study, we found that combined PP242 and curcumin treatment induced cytosolic Ca2+ release and ER stress. Interestingly, pretreatment with the chemical chaperones (TUDCA and 4-PBA) and knockdown of CHOP and ATF4 by siRNA did not abolish combined treatment-induced apoptosis in renal carcinoma cells....
Source: Molecules - October 24, 2018 Category: Chemistry Authors: Seung Un Seo Kyoung-jin Min Seon Min Woo Ji Hae Seo Taeg Kyu Kwon Tags: Article Source Type: research

Molecules, Vol. 23, Pages 2828: 8e Protects against Acute Cerebral Ischemia by Inhibition of PI3K γ-Mediated Superoxide Generation in Microglia
Molecules, Vol. 23, Pages 2828: 8e Protects against Acute Cerebral Ischemia by Inhibition of PI3Kγ-Mediated Superoxide Generation in Microglia Molecules doi: 10.3390/molecules23112828 Authors: Linna Wang Xiaoli Wang Tingting Li Yihua Zhang Hui Ji The inflammatory response mediated by microglia plays a critical role in the progression of ischemic stroke. Phosphoinositide 3-kinase gamma (PI3Kγ) has been implicated in multiple inflammatory and autoimmune diseases, making it a promising target for therapeutic intervention. The aim of this study was to evaluate the efficacy of 8e, a hydrogen sulfi...
Source: Molecules - October 31, 2018 Category: Chemistry Authors: Linna Wang Xiaoli Wang Tingting Li Yihua Zhang Hui Ji Tags: Article Source Type: research

Molecules, Vol. 23, Pages 2884: Identification and Characterization of NTB451 as a Potential Inhibitor of Necroptosis
Tae-Bong Kang Necroptosis, or caspase-independent programmed cell death, is known to be involved in various pathological conditions, such as ischemia/reperfusion injury, myocardial infarction, atherosclerosis, and inflammatory bowel diseases. Although several inhibitors of necroptosis have been identified, none of them are currently in clinical use. In the present study, we identified a new compound, 4-({[5-(4-aminophenyl)-4-ethyl-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)-N-(1,3-thiazol-2-yl) benzamide (NTB451), with significant inhibitory activity on the necroptosis induced by various triggers, such as tumor necrosis fac...
Source: Molecules - November 5, 2018 Category: Chemistry Authors: Eun-Jung In Yuno Lee Sushruta Koppula Tae-Yeon Kim Jun-Hyuk Han Kwang-Ho Lee Tae-Bong Kang Tags: Article Source Type: research

Molecules, Vol. 23, Pages 3209: Aquaporin 11-Dependent Inhibition of Proliferation by Deuterium Oxide in Activated Hepatic Stellate Cells
Pyo Kim Deuterium oxide (D2O) has been reported to be active toward various in vitro cell lines in combination with phytochemicals. Our objective was to describe, for the first time, the effect of D2O on the proliferation of hepatic stellate cells (HSCs). After D2O treatment, the p53-cyclin-dependent kinase (CDK) pathway was stimulated, leading to inhibition of the proliferation of HSCs and an increase in the [ATP]/[ADP] ratio. We also evaluated the role of aquaporin (AQP) 11 in activated HSCs. We found that D2O treatment decreased AQP11 expression levels. Of note, AQP11 levels elevated by a genetic approach counteract...
Source: Molecules - December 5, 2018 Category: Chemistry Authors: Phil Jun Lee Hye-Jin Park Namki Cho Hong Pyo Kim Tags: Article Source Type: research

Molecules, Vol. 23, Pages 3306: 23-Hydroxyursolic Acid Isolated from the Stem Bark of Cussonia bancoensis Induces Apoptosis through Fas/Caspase-8-Dependent Pathway in HL-60 Human Promyelocytic Leukemia Cells
san Kyung-Tae Lee The natural product 23-hydroxyursolic acid (23-HUA) is a derivative of ursolic acid, which is known to induce cancer cell apoptosis. However, apoptotic effects and mechanisms of 23-HUA have not been well characterized yet. Herein, we investigated the molecular mechanisms of 23-HUA-induced apoptosis in HL-60 human promyelocytic leukemia cells. 23-HUA-treated HL-60 cells showed apoptotic features including internucleosomal DNA condensation and fragmentation as well as externalization of phosphatidylserine residues. 23-HUA induced a series of mitochondrial events including disruption of mitochondrial m...
Source: Molecules - December 13, 2018 Category: Chemistry Authors: Jong-Heon Won Kyung-Sook Chung Eun-Young Park Jeong-Hun Lee Jung-Hye Choi Leon Azefack Tapondjou Hee-Juhn Park Masaaki Nomura Ahmed H.E. Hassan Kyung-Tae Lee Tags: Article Source Type: research