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Total 981 results found since Jan 2013.

Molecules, Vol. 28, Pages 560: Advances in the Chemistry, Analysis and Adulteration of Anthocyanin Rich-Berries and Fruits: 2000 & ndash;2022
Molecules, Vol. 28, Pages 560: Advances in the Chemistry, Analysis and Adulteration of Anthocyanin Rich-Berries and Fruits: 2000–2022 Molecules doi: 10.3390/molecules28020560 Authors: Bharathi Avula Kumar Katragunta Ahmed G. Osman Zulfiqar Ali Sebastian John Adams Amar G. Chittiboyina Ikhlas A. Khan Anthocyanins are reported to exhibit a wide variety of remedial qualities against many human disorders, including antioxidative stress, anti-inflammatory activity, amelioration of cardiovascular diseases, improvement of cognitive decline, and are touted to protect against neurodegenerative disorder...
Source: Molecules - January 5, 2023 Category: Chemistry Authors: Bharathi Avula Kumar Katragunta Ahmed G. Osman Zulfiqar Ali Sebastian John Adams Amar G. Chittiboyina Ikhlas A. Khan Tags: Review Source Type: research

Molecules, Vol. 28, Pages 1092: Developed and Validated Capillary Isotachophoresis Method for the Rapid Determining Organic Acids in Children & rsquo;s Saliva
This study aims to develop a reliable analytical method using the capillary isotachophoresis technique for the determination of organic acids in children’s saliva, the presence/elevation of which can be used in the future for diagnostic purposes. Organic acids such as formic, lactic, acetic, propionic, and butyric acid, were determined in the saliva of healthy children without carious lesions. The limit of quantification determined in the validation process was found to vary from 0.05 to 1.56 mg/L, the recoveries at the two levels were determined to vary between 90% and 110% for level I, while for level II th...
Source: Molecules - January 21, 2023 Category: Chemistry Authors: Justyna Dobrowolska-Iwanek Ma łgorzata Jamka-Kasprzyk Marcelina Rusin Pawe ł Paśko Sviatoslav Grekh Anna Jurczak Tags: Communication Source Type: research

Molecules, Vol. 28, Pages 3639: Biological Potential of Carnivorous Plants from Nepenthales
achno Since Charles Darwin and his book carnivorous plants have aroused interest and heated debate. In addition, there is growing interest in this group of plants as a source of secondary metabolites and in the application of their biological activity. The aim of this study was to trace the recent literature in search of the application of extracts obtained from families Droseraceae, Nepenthaceae, and Drosophyllaceae to show their biological potential. The data collected in the review clearly indicate that the studied Nepenthales species have great biological potential in terms of antibacterial, antifungal, antioxidant...
Source: Molecules - April 21, 2023 Category: Chemistry Authors: Magdalena W ójciak Marcin Feldo Piotr Stolarczyk Bartosz J. P łachno Tags: Review Source Type: research

Molecules, Vol. 28, Pages 4381: Natural Bacterial and Fungal Peptides as a Promising Treatment to Defeat Lung Cancer Cells
This article is a literature review of research on compounds of natural origin that can potentially be used as part of NSCLC therapies.
Source: Molecules - May 27, 2023 Category: Chemistry Authors: Kamila Rybczy ńska-Tkaczyk Anna Grenda Anna Jakubczyk Pawe ł Krawczyk Tags: Review Source Type: research

Molecules, Vol. 28, Pages 5653: Plectranthus Species with Anti-Inflammatory and Analgesic Potential: A Systematic Review on Ethnobotanical and Pharmacological Findings
This study identified twelve Plectranthus species indicated for the treatment of different inflammatory conditions, such as wounds, fever, bronchitis, abscess, asthma, hepatitis, labyrinthitis, tonsillitis, and uterine inflammation. The indications for pain conditions included headache, sore throat, heartburn, menstrual cramp, colic, toothache, stomachache, migraine, chest pain, abdominal pain, local pain, labor pain, and recurring pain. Among the listed species, ten plants were found to be used according to traditional knowledge, although only four of them have been experimentally studied. When assessing the methodologica...
Source: Molecules - July 26, 2023 Category: Chemistry Authors: Maysa de Oliveira Barbosa Polrat Wilairatana Giovana Mendes de Lacerda Leite Gyllyandeson de Ara újo Delmondes Lucas Yure Santos da Silva Silvio Caetano Alves J únior Lindaiane Bezerra Rodrigues Dantas Daniel Souza Bezerra Izabel Cristina Santiago Lemos Tags: Systematic Review Source Type: research

Molecules, Vol. 19, Pages 19209-19219: Discovery of Novel Small-Molecule Compounds with Selective Cytotoxicity for Burkitt’s Lymphoma Cells Using 3D Ligand-Based Virtual Screening
We describe a ligand-based approach towards compounds with more specific targeting for Burkitt’s lymphoma. Using three-dimensional ligand-based similarity searches and a previously described hit compound, we have identified six compounds that are chemically different but with similar spatial conformations. Biological evaluation revealed that one compound has better growth inhibition and improved selectivity towards Burkitt’s lymphoma cells than the query compound. However, initial mechanism-of-action studies show a different target profile in comparison with the previous hit compound, which does not involve the inhibit...
Source: Molecules - November 19, 2014 Category: Chemistry Authors: Martina GobecIzidor SosičBoris BrusAleš ObrezaStanislav GobecIrena Mlinarič-Raščan Tags: Article Source Type: research

Molecules, Vol. 19, Pages 18073-18089: Anti-Inflammatory Effect of Methylpenicinoline from a Marine Isolate of Penicillium sp. (SF-5995): Inhibition of NF-κB and MAPK Pathways in Lipopolysaccharide-Induced RAW264.7 Macrophages and BV2 Microglia
In the course of a search for anti-inflammatory metabolites from marine-derived fungi, methylpenicinoline (1) was isolated from a marine isolate of Penicillin sp. Compound 1 inhibited lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production by suppressing the expression of inducible NO synthase (iNOS) in RAW264.7 macrophages and BV2 microglia. It also attenuated prostaglandin E2 (PGE2) production by suppressing cyclooxygenase-2 (COX-2) expression in a concentration-dependent manner (from 10 μM to 80 μM) without affecting cell viability. In addition, compound 1 reduced the production of the pro-inflammatory cytoki...
Source: Molecules - November 5, 2014 Category: Chemistry Authors: Dong-Cheol KimHee-Suk LeeWonmin KoDong-Sung LeeJae SohnJoung YimYoun-Chul KimHyuncheol Oh Tags: Article Source Type: research

Molecules, Vol. 19, Pages 19292-19349: Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity
Antimicrobial natural preparations involving cinnamon, storax and propolis have been long used topically for treating infections. Cinnamic acids and related molecules are partly responsible for the therapeutic effects observed in these preparations. Most of the cinnamic acids, their esters, amides, aldehydes and alcohols, show significant growth inhibition against one or several bacterial and fungal species. Of particular interest is the potent antitubercular activity observed for some of these cinnamic derivatives, which may be amenable as future drugs for treating tuberculosis. This review intends to summarize the litera...
Source: Molecules - November 25, 2014 Category: Chemistry Authors: Juan Guzman Tags: Review Source Type: research

Molecules, Vol. 19, Pages 19610-19632: Recent Advances in the Chemical Composition of Propolis
Propolis is a honeybee product with broad clinical applications. Current literature describes that propolis is collected from plant resins. From a systematic database search, 241 compounds were identified in propolis for the first time between 2000 and 2012; and they belong to such diverse chemical classes as flavonoids, phenylpropanoids, terpenenes, stilbenes, lignans, coumarins, and their prenylated derivatives, showing a pattern consistent with around 300 previously reported compounds. The chemical characteristics of propolis are linked to the diversity of geographical location, plant sources and bee species.
Source: Molecules - November 26, 2014 Category: Chemistry Authors: Shuai HuangCui-Ping ZhangKai WangGeorge LiFu-Liang Hu Tags: Review Source Type: research

Molecules, Vol. 20, Pages 348-357: Marine Sponge Lectins: Actual Status on Properties and Biological Activities
Marine sponges are primitive metazoans that produce a wide variety of molecules that protect them against predators. In studies that search for bioactive molecules, these marine invertebrates stand out as promising sources of new biologically-active molecules, many of which are still unknown or little studied; thus being an unexplored biotechnological resource of high added value. Among these molecules, lectins are proteins that reversibly bind to carbohydrates without modifying them. In this review, various structural features and biological activities of lectins derived from marine sponges so far described in the scienti...
Source: Molecules - December 26, 2014 Category: Chemistry Authors: Sandro Gomes FilhoJuscélio CardosoKatya AnayaEdilza Silva do NascimentoJosé de LacerdaRoberto MiosoTatiane Santi GadelhaCarlos de Almeida Gadelha Tags: Review Source Type: research

Molecules, Vol. 20, Pages 3027-3049: Inhibitors of the AAA+ Chaperone p97
It is remarkable that a pathway as ubiquitous as protein quality control can be targeted to treat cancer. Bortezomib, an inhibitor of the proteasome, was first approved by the US Food and Drug Administration (FDA) more than 10 years ago to treat refractory myeloma and later extended to lymphoma. Its use has increased the survival rate of myeloma patients by as much as three years. This success was followed with the recent accelerated approval of the natural product derived proteasome inhibitor carfilzomib (Kyprolis®), which is used to treat patients with bortezomib-resistant multiple myeloma. The success of these two drug...
Source: Molecules - February 12, 2015 Category: Chemistry Authors: Eli ChapmanNick MaksimFabian de la CruzJames La Clair Tags: Review Source Type: research

Molecules, Vol. 20, Pages 3309-3334: Prevention of Protein Glycation by Natural Compounds
Non-enzymatic protein glycosylation (glycation) contributes to many diseases and aging of organisms. It can be expected that inhibition of glycation may prolong the lifespan. The search for inhibitors of glycation, mainly using in vitro models, has identified natural compounds able to prevent glycation, especially polyphenols and other natural antioxidants. Extrapolation of results of in vitro studies on the in vivo situation is not straightforward due to differences in the conditions and mechanism of glycation, and bioavailability problems. Nevertheless, available data allow to postulate that enrichment of diet in natural...
Source: Molecules - February 16, 2015 Category: Chemistry Authors: Izabela Sadowska-BartoszGrzegorz Bartosz Tags: Review Source Type: research

Molecules, Vol. 20, Pages 3515-3526: Effect of Diterpenes Isolated of the Marine Alga Canistrocarpus cervicornis against Some Toxic Effects of the Venom of the Bothrops jararaca Snake
Snake venoms are composed of a complex mixture of active proteins and peptides which induce a wide range of toxic effects. Envenomation by Bothrops jararaca venom results in hemorrhage, edema, pain, tissue necrosis and hemolysis. In this work, the effect of a mixture of two secodolastane diterpenes (linearol/isolinearol), previously isolated from the Brazilian marine brown alga, Canistrocarpus cervicornis, was evaluated against some of the toxic effects induced by B. jararaca venom. The mixture of diterpenes was dissolved in dimethylsulfoxide and incubated with venom for 30 min at room temperature, and then several in vivo...
Source: Molecules - February 18, 2015 Category: Chemistry Authors: Thaisa DomingosMagui VallimDiana CavalcantiEládio SanchezValéria TeixeiraAndré Fuly Tags: Article Source Type: research

Molecules, Vol. 20, Pages 3868-3897: Rational Drug Design and Synthesis of Molecules Targeting the Angiotensin II Type 1 and Type 2 Receptors
The angiotensin II (Ang II) type 1 and type 2 receptors (AT1R and AT2R) orchestrate an array of biological processes that regulate human health. Aberrant function of these receptors triggers pathophysiological responses that can ultimately lead to death. Therefore, it is important to design and synthesize compounds that affect beneficially these two receptors. Cardiovascular disease, which is attributed to the overactivation of the vasoactive peptide hormone Αng II, can now be treated with commercial AT1R antagonists. Herein, recent achievements in rational drug design and synthesis of molecules acting on the two AT recep...
Source: Molecules - March 2, 2015 Category: Chemistry Authors: Tahsin KelliciAndreas TzakosThomas Mavromoustakos Tags: Review Source Type: research

Molecules, Vol. 20, Pages 5099-5111: Docking and Antiherpetic Activity of 2-Aminobenzode-isoquinoline-1,3-diones
As part of our search for new compounds having antiviral effects, the prepared 2-aminonaphthalimide series was examined for its activity against the herpes simplex viruses HSV-1 and HSV-2. This represents the first study of the antiviral effects of this class of compounds. The new series of 2-amino-1H-benzo[de]isoquinoline-1,3-diones was examined against HSV-1 and HSV-2 using a cytopathic effect inhibition assay. In terms of effective concentration (EC50), furaldehyde, thiophene aldehyde and allyl isothiocyanide derivatives 14‒16 showed potent activity against HSV-1 (EC50 = 19.6, 16.2 and 17.8 μg/mL), compared to acyclo...
Source: Molecules - March 19, 2015 Category: Chemistry Authors: Rashad Al-SalahiIbrahim AlswaidanHazem GhabbourEssam EzzeldinMahmoud ElaasserMohamed Marzouk Tags: Article Source Type: research