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Total 1090 results found since Jan 2013.
Molecules, Vol. 22, Pages 275: Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana
The microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs were obtained through semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher bactericidal activity than the parent molecule. The anti-microbial studies proved that I E showed high anti-bacterial activity whereas I I showed the highest anti-fung...
Source: Molecules - February 11, 2017 Category: Chemistry Authors: Srinivasan Narasimhan Shanmugam Maheshwaran Imad Abu-Yousef Amin Majdalawieh Janarthanam Rethavathi Prince Das Palmiro Poltronieri Tags: Article Source Type: research
Molecules, Vol. 22, Pages 318: Three Chalconoids and a Pterocarpene from the Roots of Tephrosia aequilata
In our search for new antiplasmodial agents, the CH2Cl2/CH3OH (1:1) extract of the roots of Tephrosia aequilata was investigated, and observed to cause 100% mortality of the chloroquine-sensitive (3D7) strain of Plasmodium falciparum at a 10 mg/mL concentration. From this extract three new chalconoids, E-2 ′,6′-dimethoxy-3′,4′-(2′′,2′′-dimethyl)pyranoretrochalcone (1, aequichalcone A), Z-2′,6′-dimethoxy-3′,4′-(2′′,2′′-dimethyl)pyranoretrochalcone (2, aequichalcone B), 4′′-ethoxy-3′′-hydroxypraecansone B (3, aequichalcone C) and a new pterocarpene, 3,4:8,9-dimeth ylenedioxy-6a,11a-pte...
Source: Molecules - February 19, 2017 Category: Chemistry Authors: Yoseph Atilaw Sandra Duffy Matthias Heydenreich Lois Muiva-Mutisya Vicky Avery M áté Erdélyi Abiy Yenesew Tags: Article Source Type: research
Molecules, Vol. 22, Pages 358: Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome
Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound from thehydroxycinnamic acid family. This polyphenol possesses many health-promoting properties, mostof them related to the treatment of metabolic syndrome, including anti-oxidant, anti-inflammatory,antilipidemic, antidiabetic, and antihypertensive activities. The first part of this review will discussthe role of chlorogenic acid as a nutraceutical for the prevention and treatment of metabolicsyndrome and associated disorders, including in vivo studies, clinical trials, and mechanisms ofaction. The second part of the review will be dealing with the role of c...
Source: Molecules - February 25, 2017 Category: Chemistry Authors: Jes ús Santana-Gálvez Luis Cisneros-Zevallos Daniel Jacobo-Vel ázquez Tags: Review Source Type: research
Molecules, Vol. 22, Pages 451: Chemical Constituents of Smilax china L. Stems and Their Inhibitory Activities against Glycation, Aldose Reductase, α-Glucosidase, and Lipase
The search for natural inhibitors with anti-diabetes properties has gained increasing attention. Among four selected Smilacaceae family plants, Smilax china L. stems (SCS) showed significant in vitro anti-glycation and rat lens aldose reductase inhibitory activities. Bioactivity-guided isolation was performed with SCS and four solvent fractions were obtained, which in turn yielded 10 compounds, including one phenolic acid, three chlorogenic acids, four flavonoids, one stilbene, and one phenylpropanoid glycoside; their structures were elucidated using nuclear magnetic resonance and mass spectrometry. All solvent fractions, ...
Source: Molecules - March 10, 2017 Category: Chemistry Authors: Hee Lee Jin Kim Wan Whang Tags: Article Source Type: research
Molecules, Vol. 22, Pages 532: Constituents of the Roots of Dichapetalum pallidum and Their Anti-Proliferative Activity
As part of our search for bioactive compounds from the Dichapetalaceae, repeated chromatographic purification of the roots of a hitherto unexamined species, Dichapetalum pallidum, led to the isolation of the newly occurring 7-hydroxydichapetalin P (1) and the known dichapetalins A (2) and X (3). Also isolated were the known compounds friedelin-2,3-lactone (4), friedelan-3-one (6), friedelan-3 β-ol (7) and pomolic (8), as well as the dipeptide aurantiamide acetate (5). The compounds were characterized by direct interpretation of their IR, 1D NMR and 2D NMR spectral data and by comparison of their physico-chemical data, inc...
Source: Molecules - March 27, 2017 Category: Chemistry Authors: Dorcas Osei-Safo Godwin Akpeko Dziwornu Regina Appiah-Opong Mary Anti Chama Isaac Tuffour Reiner Waibel Richard Amewu Ivan Addae-Mensah Tags: Article Source Type: research
Molecules, Vol. 22, Pages 597: Anti-Trypanosomatid Elemanolide Sesquiterpene Lactones from Vernonia lasiopus O. Hoffm
Sleeping sickness or human African trypanosomiasis (HAT) is a neglected tropical disease (NTD) threatening millions of peoples ’ lives with thousands infected. The disease is endemic in poorly developed regions of sub-Saharan Africa and is caused by the kinetoplastid “protozoan” parasite Trypanosoma brucei. The parasites are transmitted to humans through bites of infected tsetse flies of the genus Glossina. The few av ailable drugs for treatment of this disease are highly toxic, difficult to administer, costly and unavailable to poor rural communities bearing the major burden of this infection. Therefore, the search ...
Source: Molecules - April 8, 2017 Category: Chemistry Authors: Njogu Kimani Josphat Matasyoh Marcel Kaiser Reto Brun Thomas Schmidt Tags: Article Source Type: research
Molecules, Vol. 22, Pages 685: Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some Natural Sesquiterpene Lactones
Leishmaniases are neglected infectious diseases caused by parasites of the ‘protozoan’ genus Leishmania. Depending on the parasite species, different clinical forms are known as cutaneous, muco-cutaneous, and the visceral leishmaniasis (VL). VL is particularly fatal and the therapy presents limitations. In the search for new anti-leishmanial hit compounds, seven natura l sesquiterpene lactones were evaluated against promastigotes and intracellular amastigotes of Leishmania (Leishmania) infantum, a pathogen causing VL. The pseudoguaianolides mexicanin I and helenalin acetate demonstrated the highest selectivity and pote...
Source: Molecules - April 25, 2017 Category: Chemistry Authors: Imke Wulsten Thais Costa-Silva Juliana Mesquita Marta Lima Mariana Galuppo Noemi Taniwaki Samanta Borborema Fernando Da Costa Thomas Schmidt Andre Tempone Tags: Article Source Type: research
Molecules, Vol. 22, Pages 756: Hepatoprotective Effect of Carboxymethyl Pachyman in Fluorouracil-Treated CT26-Bearing Mice
5-Fluorouracil (5-FU) is the chemotherapeutic agent of first choice for the treatment ofcolorectal cancer, however, treatment-related liver toxicity remains a major concern. Thereby, it is desirable to search for novel therapeutic approaches that can effectively enhance curative effects and reduce the toxic side effects of 5-FU. Carboxymethyl Pachyman (CMP) exhibits strong antitumor properties, but the antitumor and hepatoprotective effects of CMP and the molecular mechanisms behind these activities, are however poorly explored. Thereby, the purpose of the present study was to evaluate the hepatoprotective effect of CMP in...
Source: Molecules - May 6, 2017 Category: Chemistry Authors: Canhong Wang Xiaowei Huo Li Gao Guibo Sun Cao Li Tags: Article Source Type: research
Molecules, Vol. 22, Pages 824: Effects of Growth Media on the Diversity of Culturable Fungi from Lichens
Microscopic and molecular studies suggest that lichen symbioses contain a plethora of associated fungi. These are potential producers of novel bioactive compounds, but strains isolated on standard media usually represent only a minor subset of these fungi. By using various in vitro growth conditions we are able to modulate and extend the fraction of culturable lichen-associated fungi. We observed that the presence of iron, glucose, magnesium and potassium in growth media is essential for the successful isolation of members from different taxonomic groups. According to sequence data, most isolates besides the lichen mycobio...
Source: Molecules - May 17, 2017 Category: Chemistry Authors: Lucia Muggia Theodora Kopun Martin Grube Tags: Article Source Type: research
Molecules, Vol. 22, Pages 869: In Silico Study and Bioprospection of the Antibacterial and Antioxidant Effects of Flavone and Its Hydroxylated Derivatives
This study set out to investigate the probable pharmacological activities, along with the antibacterial and antioxidant effects, of flavone and its hydroxy derivatives: 3-hydroxyflavone, 5-hydroxyflavone and 6-hydroxyflavone. To do so, we investigated their pharmacological characteristics, using in silico tests that indicate likelihood of activity or inactivity, with the PASS online software, and the antimicrobial potential against Gram positive and Gram negative bacteria was also analyzed, including bacteria of clinical importance. We also tested for oxidant and antioxidant potential in these molecules in the presence of ...
Source: Molecules - May 24, 2017 Category: Chemistry Authors: Camila Montenegro Greg ório Gonçalves Abrah ão Oliveira Filho Andressa Lira Thays Cassiano Natanael Lima Jos é Barbosa-Filho Margareth Diniz Hilzeth Pess ôa Tags: Article Source Type: research
Molecules, Vol. 22, Pages 871: Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition
Multidrug resistance (MDR) is regarded as one of the bottlenecks of successful clinical treatment for numerous chemotherapeutic agents. Multiple key regulators are alleged to be responsible for MDR and making the treatment regimens ineffective. In this review, we discuss MDR in relation to P-glycoprotein (P-gp) and its down-regulation by natural bioactive molecules. P-gp, a unique ATP-dependent membrane transport protein, is one of those key regulators which are present in the lining of the colon, endothelial cells of the blood brain barrier (BBB), bile duct, adrenal gland, kidney tubules, small intestine, pancreatic ducts...
Source: Molecules - May 25, 2017 Category: Chemistry Authors: Saikat Dewanjee Tarun Dua Niloy Bhattacharjee Anup Das Moumita Gangopadhyay Ritu Khanra Swarnalata Joardar Muhammad Riaz Vincenzo Feo Muhammad Zia-Ul-Haq Tags: Review Source Type: research
Molecules, Vol. 22, Pages 1029: Virtual Screening against Phosphoglycerate Kinase 1 in Quest of Novel Apoptosis Inhibitors
Inhibition of apoptosis is a potential therapy to treat human diseases such as neurodegenerative disorders (e.g., Parkinson ’s disease), stroke, and sepsis. Due to the lack of druggable targets, it remains a major challenge to discover apoptosis inhibitors. The recent repositioning of a marketed drug (i.e., terazosin) as an anti-apoptotic agent uncovered a novel target (i.e., human phosphoglycerate kinase 1 (hPgk1)). I n this study, we developed a virtual screening (VS) pipeline based on the X-ray structure of Pgk1/terazosin complex and applied it to a screening campaign for potential anti-apoptotic agents. The hierarchi...
Source: Molecules - June 21, 2017 Category: Chemistry Authors: Jie Xia Bo Feng Qianhang Shao Yuhe Yuan Xiang Wang Naihong Chen Song Wu Tags: Article Source Type: research
Molecules, Vol. 22, Pages 1129: Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense
In our continued search for natural compounds with activity against Trypanosoma brucei, causative agent of human African trypanosomiasis (HAT, “sleeping sickness”), we have investigated extracts from the leaves and bark of the West African Holarrhena africana (syn. Holarrhena floribunda; Apocynaceae). The extracts and their alkaloid-enriched fractions displayed promising in vitro activity against bloodstream forms of T. brucei rhodesie nse (Tbr; East African HAT). Bioactivity-guided chromatographic fractionation of the alkaloid-rich fractions resulted in the isolation of 17 steroid alkaloids, one nitrogen-free steroid ...
Source: Molecules - July 6, 2017 Category: Chemistry Authors: Charles Okeke Nnadi Ngozi Justina Nwodo Marcel Kaiser Reto Brun Thomas J. Schmidt Tags: Article Source Type: research
Molecules, Vol. 22, Pages 1238: Quality Assessment of Gentiana rigescens from Different Geographical Origins Using FT-IR Spectroscopy Combined with HPLC
ng Wang
Gentiana rigescens is a precious herbal medicine in China because of its liver-protective and choleretic effects. A method for the qualitative identification and quantitative evaluation of G. rigescens from Yunnan Province, China, has been developed employing Fourier transform infrared (FT-IR) spectroscopy and high performance liquid chromatography (HPLC) with the aid of chemometrics such as partial least squares discriminant analysis (PLS-DA) and support vector machines (SVM) regression. Our results indicated that PLS-DA model could efficiently discriminate G. rigescens from different geographical origins. It ...
Source: Molecules - July 24, 2017 Category: Chemistry Authors: Zhe Wu Yanli Zhao Ji Zhang Yuanzhong Wang Tags: Article Source Type: research
Molecules, Vol. 22, Pages 1290: Essential Oils and Their Constituents: An Alternative Source for Novel Antidepressants
avioli
Depression is a disease that has affected a high proportion of the world’s population and people of different ages, incapacitating them from good performance at work and in social relationships, and causing emotional disorders to millions of families. Therefore, the search for new therapeutic agents is considered a priority for the discovery of more effective forms of treatment. In this review, studies of essential oils and their constituents in experimental models related to depression are discussed. The mechanisms of action of the oils and the presence of psychoactive constituents in their chemical compositi...
Source: Molecules - August 3, 2017 Category: Chemistry Authors: Dami ão de Sousa Rayanne Silva Epifanio Silva Elaine Gavioli Tags: Review Source Type: research
