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Total 1090 results found since Jan 2013.
Molecules, Vol. 20, Pages 19252-19262: Cytotoxicity of Triterpenes from Green Walnut Husks of Juglans mandshurica Maxim in HepG-2 Cancer Cells
Among the classes of identified natural products, triterpenoids, one of the largest families, have been studied extensively for their diverse structures and variety of biological activities, including antitumor effects. In the present study, a phytochemical study of the green walnut husks of Juglans mandshurica Maxim led to the isolation of a new dammarane triterpene, 12β, 20(R), 24(R)-trihydroxydammar-25-en-3-one (6), together with sixteen known compounds, chiefly from chloroform and ethyl acetate extracts. According to their structural characteristics, these compounds were divided into dammarane-type, oleanane- and ursa...
Source: Molecules - October 22, 2015 Category: Chemistry Authors: Yuanyuan ZhouBingyou YangZhaoxi LiuYanqiu JiangYuxin LiuLei FuXiaoli WangHaixue Kuang Tags: Article Source Type: research
Molecules, Vol. 20, Pages 20219-20229: Genetic Authentication of Gardenia jasminoides Ellis var. grandiflora Nakai by Improved RAPD-Derived DNA Markers
The evergreen shrub, Gardenia jasminoides Ellis var. grandiflora Nakai is one of the most popular garden-plants, with significant ornamental importance. Here, we have cloned improved random amplified polymorphic DNA (RAPD) derived fragments into T-vector, and developed sequence-characterized amplified region (SCAR) markers. These markers have been deposited in GenBank database with the accession numbers KP641310, KP641311, KP641312 and KP641313 respectively. The BLAST search of database confirmed the novelty of these markers. The four SCAR markers, namely ZZH11, ZZH31, ZZH41 and ZZH51 can specifically recognize the geneti...
Source: Molecules - November 10, 2015 Category: Chemistry Authors: Zhiqiang MeiBoxu ZhouChunli WeiJingliang ChengSaber ImaniHanchun ChenJunjiang Fu Tags: Article Source Type: research
Molecules, Vol. 20, Pages 20967-20978: Pyranocoumarins from Root Extracts of Peucedanum praeruptorum Dunn with Multidrug Resistance Reversal and Anti-Inflammatory Activities
In the search for novel herbal-based anticancer agents, we isolated a new angular-type pyranocoumarin, (+)-cis-(3′S,4′S)-3′-angeloyl-4′-tigloylkhellactone (1) along with 12 pyranocoumarins (2–13), two furanocoumarins (14, 15), and a polyacetylene (16) were isolated from the roots of Peucedanum praeruptorum using chromatographic separation methods. The structures of the compounds were determined using spectroscopic analysis with nuclear magnetic resonance (NMR) and high-resolution-electrospray ionization-mass spectrometry (HR-ESI-MS). The multidrug-resistance (MDR) reversal and anti-inflammatory effects of all the...
Source: Molecules - November 25, 2015 Category: Chemistry Authors: Jun LeeYou LeeJinhee KimOk-Sun Bang Tags: Article Source Type: research
Molecules, Vol. 20, Pages 21214-21231: Characterization of Global Transcriptome Using Illumina Paired-End Sequencing and Development of EST-SSR Markers in Two Species of Gynostemma (Cucurbitaceae)
In this study, transcriptomes of two closely-related Gynostemma species, Gynostemma cardiospermum and G. pentaphyllum, were sequenced using Illumina paired-end sequencing technology. A total of 71,607 nonredundant unigenes were assembled. Of these unigenes, 60.45% (43,288) were annotated based on sequence similarity search with known proteins. A total of 11,059 unigenes were identified in the Kyoto Encyclopedia of Genes and Genomes Pathway (KEGG) database. A total of 3891 simple sequence repeats (SSRs) were detected in 3526 nonredundant unigenes, 2596 primer pairs were designed and 360 of them were randomly selected for va...
Source: Molecules - November 30, 2015 Category: Chemistry Authors: Yue-Mei ZhaoTao ZhouZhong-Hu LiGui-Fang Zhao Tags: Article Source Type: research
Molecules, Vol. 20, Pages 21336-21345: Isoeugenin, a Novel Nitric Oxide Synthase Inhibitor Isolated from the Rhizomes of Imperata cylindrica
Phytochemical studies on the constituents of the rhizomes of Imperata cylindrica (Gramineae) were performed using high-performance liquid chromatography (HPLC). We also aimed to search for any biologically active substance capable of inhibiting nitric oxide (NO) formation in lipopolysaccharide (LPS)-activated macrophage 264.7 cells, by testing four compounds isolated from this plant. Four compounds, including a new chromone, isoeugenin, along with ferulic acid, p-coumaric acid, and caffeic acid were isolated and identified by NMR spectroscopy. The structure of isoeugenin was determined as 7-hydroxy-5-methoxy-2-methylchromo...
Source: Molecules - December 1, 2015 Category: Chemistry Authors: Hyo-Jin AnAgung NugrohoByong-Min SongHee-Juhn Park Tags: Article Source Type: research
Molecules, Vol. 20, Pages 22146-22156: Impact of Natural Juice Consumption on Plasma Antioxidant Status: A Systematic Review and Meta-Analysis
Conclusions: Natural juices are possible candidates for the management of oxidative stress. The effects of juices should be further investigated by conducting larger and well-defined trials of longer duration.
Source: Molecules - December 10, 2015 Category: Chemistry Authors: Fernanda ToninLaiza SteimbachAstrid WiensCássio PerlinRoberto Pontarolo Tags: Article Source Type: research
Molecules, Vol. 21, Pages 209: Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil
Drug resistance in the treatment of neglected parasitic diseases, such as leishmaniasis and trypanosomiasis, has led to the search and development of alternative drugs from plant origins. In this context, the essential oil extracted by hydro-distillation from Lantana camara leaves was tested against Leishmania braziliensis and Trypanosoma cruzi. The results demonstrated that L. camara essential oil inhibited T. cruzi and L. braziliensis with IC50 of 201.94 μg/mL and 72.31 μg/mL, respectively. L. camara essential oil was found to be toxic to NCTC929 fibroblasts at 500 μg/mL (IC50 = 301.42 μg/mL). The composition of L. c...
Source: Molecules - February 10, 2016 Category: Chemistry Authors: Luiz BarrosAntonia DuarteMaria Morais-BragaEmily WaczukCeleste VegaNadghia LeiteIrwin de MenezesHenrique CoutinhoJoão RochaJean Kamdem Tags: Article Source Type: research
Molecules, Vol. 21, Pages 240: The Impact of Melatonin in Research
This study represents the first detailed analysis of the 100 top-cited articles published in the field of melatonin research, showing its impact and relevance in the biomedical field.
Source: Molecules - February 20, 2016 Category: Chemistry Authors: Elena VaroniClelia SoruRoberta PluchinoChiara IntraMarcello Iriti Tags: Review Source Type: research
Molecules, Vol. 21, Pages 251: Phenolics from Garcinia mangostana Inhibit Advanced Glycation Endproducts Formation: Effect on Amadori Products, Cross-Linked Structures and Protein Thiols
In conclusion, phenolic compounds 1–4 inhibited AGEs formation at the levels of Amadori product and protein aggregation formation through saving protein thiol.
Source: Molecules - February 22, 2016 Category: Chemistry Authors: Hossam AbdallahHany El-BassossyGamal MohamedAli El-HalawanyKhalid AlshaliZainy Banjar Tags: Article Source Type: research
Molecules, Vol. 21, Pages 247: Chemistry and Pharmacology of Citrus sinensis
Presently the search for new drugs from natural resources is of growing interest to the pharmaceutical industry. Natural products have been the source of new drugs since ancient times. Plants are a good source of secondary metabolites which have been found to have beneficial properties. The present study is a review of the chemistry and pharmacology of Citrus sinensis. This review reveals the therapeutic potential of C. sinensis as a source of natural compounds with important activities that are beneficial for human health that could be used to develop new drugs.
Source: Molecules - February 22, 2016 Category: Chemistry Authors: Juan Favela-HernándezOmar González-SantiagoMónica Ramírez-CabreraPatricia Esquivel-FerriñoMaría Camacho-Corona Tags: Review Source Type: research
Molecules, Vol. 21, Pages 336: New Anti-HBV C-Boivinopyranosyl Flavones from Alternanthera philoxeroides
C-boivinopyranosyl flavones have rarely been isolated from nature. In the search for anti-HBV (hepatitis b virus) constituents of Alternanthera philoxeroides, two new compounds, luteolin-6-C-β-d-boivinopyranosyl-3′-O-β-d-glucopyranoside (1) and chrysoeriol-6-C-β-d-boivinopyranosyl-4′-O-β-d-glucopyranoside (2), along with three known C-boivinopyranosyl flavones (compounds 3–5) were isolated. Their structures were determined by spectroscopic analyses including 1D and 2D NMR, HR-ESI-MS, IR spectra. Compounds 1, 2 and 3 showed significant anti-HBV activities through specifically inhibiting the secretion of HBsAg in HepG2.2.15.
Source: Molecules - March 14, 2016 Category: Chemistry Authors: Bin LiQing-Lan GuoYing TianShi-Jun LiuQiong WangLi ChenJun-Xing Dong Tags: Article Source Type: research
Molecules, Vol. 21, Pages 410: Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta
Cholinesterases and amyloid beta are one of the major biological targets in the search for a new and efficacious treatment of Alzheimer’s disease. The study describes synthesis and pharmacological evaluation of new compounds designed as dual binding site acetylcholinesterase inhibitors. Among the synthesized compounds, two deserve special attention—compounds 42 and 13. The former is a saccharin derivative and the most potent and selective acetylcholinesterase inhibitor (EeAChE IC50 = 70 nM). Isoindoline-1,3-dione derivative 13 displays balanced inhibitory potency against acetyl- and butyrylcholinesterase (BuChE) (EeACh...
Source: Molecules - March 25, 2016 Category: Chemistry Authors: Michalina HebdaMarek BajdaAnna WięckowskaNatalia SzałajAnna PasiekaDawid PanekJustyna GodyńTomasz WichurDamijan KnezStanislav GobecBarbara Malawska Tags: Article Source Type: research
Molecules, Vol. 21, Pages 439: Photophysical Characterization and in Vitro Phototoxicity Evaluation of 5,10,15,20-Tetra(quinolin-2-yl)porphyrin as a Potential Sensitizer for Photodynamic Therapy
Photodynamic therapy (PDT) is a selective and minimally invasive therapeutic approach, involving the combination of a light-sensitive compound, called a photosensitizer (PS), visible light and molecular oxygen. The interaction of these per se harmless agents results in the production of reactive species. This triggers a series of cellular events that culminate in the selective destruction of cancer cells, inside which the photosensitizer preferentially accumulates. The search for ideal PDT photosensitizers has been a very active field of research, with a special focus on porphyrins and porphyrin-related macrocycle molecule...
Source: Molecules - March 30, 2016 Category: Chemistry Authors: Letícia CostaJoana SilvaSofia FonsecaCláudia ArranjaAna UrbanoAbilio Sobral Tags: Article Source Type: research
Molecules, Vol. 21, Pages 466: Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer’s Disease
Multitarget drug discovery is one of the hottest topics and most active fields in the search for new molecules against Alzheimer’s disease (AD). Over the last 20 years, many promising multitarget-directed ligands (MTDLs) have been identified and developed at a pre-clinical level. However, how to design them in a rational way remains the most fundamental challenge of medicinal chemists. This is related to the foundational question of achieving an optimized activity towards multiple targets of interest, while preserving drug-like properties. In this respect, large hybrid molecules and small fragments are poles apart. In th...
Source: Molecules - April 7, 2016 Category: Chemistry Authors: Federica PratiAndrea CavalliMaria Bolognesi Tags: Review Source Type: research
