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Molecules, Vol. 28, Pages 3228: Therapeutic Potential of Albumin Nanoparticles Encapsulated Visnagin in MDA-MB-468 Triple-Negative Breast Cancer Cells
iah Pooi Ling Mok Breast cancer is among the most recurrent malignancies, and its prevalence is rising. With only a few treatment options available, there is an immediate need to search for better alternatives. In this regard, nanotechnology has been applied to develop potential chemotherapeutic techniques, particularly for cancer therapy. Specifically, albumin-based nanoparticles are a developing platform for the administration of diverse chemotherapy drugs owing to their biocompatibility and non-toxicity. Visnagin, a naturally derived furanochromone, treats cancers, epilepsy, angina, coughs, and inflammatory illnes...
Source: Molecules - April 4, 2023 Category: Chemistry Authors: Abdullah Alsrhani Abozer Y. Elderdery Badr Alzahrani Nasser A. N. Alzerwi Maryam Musleh Althobiti Musaed Rayzah Bandar Idrees Ahmed M. E. Elkhalifa Suresh K. Subbiah Pooi Ling Mok Tags: Article Source Type: research

Molecules, Vol. 28, Pages 750: Molecular Aspects and Therapeutic Implications of Herbal Compounds Targeting Different Types of Cancer
ona Gabriela Bungau Due to genetic changes in DNA (deoxyribonucleic acid) sequences, cancer continues to be the second most prevalent cause of death. The traditional target-directed approach, which is confronted with the importance of target function in healthy cells, is one of the most significant challenges in anticancer research. Another problem with cancer cells is that they experience various mutations, changes in gene duplication, and chromosomal abnormalities, all of which have a direct influence on the potency of anticancer drugs at different developmental stages. All of these factors combine to make cancer med...
Source: Molecules - January 11, 2023 Category: Chemistry Authors: Aditi Sharma Lalit Sharma Shouvik Kumar Nandy Nazrana Payal Shivam Yadav Celia Vargas-De-La-Cruz Md. Khalid Anwer Haroon Khan Tapan Behl Simona Gabriela Bungau Tags: Review Source Type: research

Molecules, Vol. 27, Pages 3623: Synthesis and Antiproliferative Activity of Novel Dehydroabietic Acid-Chalcone Hybrids
hanassopoulos Dehydroabietic Acid (DHA, 1) derivatives are known for their antiproliferative properties, among others. In the context of this work, DHA was initially modified to two key intermediates bearing a C18 methyl ester, a phenol moiety at C12, and an acetyl or formyl group at C13 position. These derivatives allowed us to synthesize a series of DHA-chalcone hybrids, suitable for structure–activity relationship studies (SARS), following their condensation with a variety of aryl-aldehydes and methyl ketones. The antiproliferative evaluation of the synthesized DHA-chalcone hybrids against three breast...
Source: Molecules - June 5, 2022 Category: Chemistry Authors: Sophia Grigoropoulou Dimitra Manou Antonia I. Antoniou Artemis Tsirogianni Carlo Siciliano Achilleas D. Theocharis Constantinos M. Athanassopoulos Tags: Article Source Type: research

Molecules, Vol. 27, Pages 3036: A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship
Al-Hossain Fukase Cancer is a disorder that rigorously affects the human population worldwide. There is a steady demand for new remedies to both treat and prevent this life-threatening sickness due to toxicities, drug resistance and therapeutic failures in current conventional therapies. Researchers around the world are drawing their attention towards compounds of natural origin. For decades, human beings have been using the flora of the world as a source of cancer chemotherapeutic agents. Currently, clinically approved anticancer compounds are vincristine, vinblastine, taxanes, and podophyllotoxin, all of which com...
Source: Molecules - May 9, 2022 Category: Chemistry Authors: Mazumder Aktar Roy Biswas Hossain Sarkar Bachar Ahmed Monjur-Al-Hossain Fukase Tags: Review Source Type: research

Molecules, Vol. 27, Pages 1414: Drug Repurposing and De Novo Drug Discovery of Protein Kinase Inhibitors as New Drugs against Schistosomiasis
o H. Falcone Schistosomiasis is a neglected tropical disease affecting more than 200 million people worldwide. Chemotherapy relies on one single drug, praziquantel, which is safe but ineffective at killing larval stages of this parasite. Furthermore, concerns have been expressed about the rise in resistance against this drug. In the absence of an antischistosomal vaccine, it is, therefore, necessary to develop new drugs against the different species of schistosomes. Protein kinases are important molecules involved in key cellular processes such as signaling, growth, and differentiation. The kinome of schistosomes has b...
Source: Molecules - February 19, 2022 Category: Chemistry Authors: Bernardo Pereira Moreira Michael H. W. Weber Simone Haeberlein Annika S. Mokosch Bernhard Spengler Christoph G. Grevelding Franco H. Falcone Tags: Review Source Type: research

Molecules, Vol. 26, Pages 6196: Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review
usun Ozer Zeolites and zeolitic imidazolate frameworks (ZIFs) are widely studied as drug carrying nanoplatforms to enhance the specificity and efficacy of traditional anticancer drugs. At present, there is no other systematic review that assesses the potency of zeolites/ZIFs as anticancer drug carriers. Due to the porous nature and inherent pH-sensitive properties of zeolites/ZIFs, the compounds can entrap and selectively release anticancer drugs into the acidic tumor microenvironment. Therefore, it is valuable to provide a comprehensive overview of available evidence on the topic to identify the benefits of the compou...
Source: Molecules - October 14, 2021 Category: Chemistry Authors: Jessica Hao Ivana Stavljeni ć Milašin Zeynep Batu Eken Marinka Mravak-Stipetic Kre šimir Pavelić Fusun Ozer Tags: Review Source Type: research

Molecules, Vol. 26, Pages 4329: Is Curcumin the Answer to Future Chemotherapy Cocktail?
Hong Chuah The rise in cancer cases in recent years is an alarming situation worldwide. Despite the tremendous research and invention of new cancer therapies, the clinical outcomes are not always reassuring. Cancer cells could develop several evasive mechanisms for their survivability and render therapeutic failure. The continuous use of conventional cancer therapies leads to chemoresistance, and a higher dose of treatment results in even greater toxicities among cancer patients. Therefore, the search for an alternative treatment modality is crucial to break this viscous cycle. This paper explores the suitability of c...
Source: Molecules - July 17, 2021 Category: Chemistry Authors: Wei Yang Kong Siew Ching Ngai Bey Hing Goh Learn-Han Lee Thet Thet Htar Lay Hong Chuah Tags: Review Source Type: research

Molecules, Vol. 26, Pages 2612: A Novel N-Tert-Butyl Derivatives of Pseudothiohydantoin as Potential Target in Anti-Cancer Therapy
Woźniak Tumors are currently more and more common all over the world; hence, attempts are being made to explain the biochemical processes underlying their development. The search for new therapeutic pathways, with particular emphasis on enzymatic activity and its modulation regulating the level of glucocorticosteroids, may contribute to the development and implementation of new therapeutic options in the treatment process. Our research focuses on understanding the role of 11β-HSD1 and 11β-HSD2 as factors involved in the differentiation and proliferation of neoplastic cells. In this work, we obtained the 9 novel N-t...
Source: Molecules - April 29, 2021 Category: Chemistry Authors: Daria Kupczyk Renata Studzi ńska Szymon Baumgart Rafa ł Bilski Tomasz Kosmalski Renata Ko łodziejska Alina Wo źniak Tags: Article Source Type: research

Molecules, Vol. 26, Pages 2045: The Anticancer Action of a Novel 1,2,4-triazine Sulfonamide Derivative in Colon Cancer Cells
a Bielawska Cancer therapy is one of the most important challenges of modern medical and chemical sciences. Among the many methods of combating cancer, chemotherapy plays a special role. Imperfect modern chemotherapy justifies continuing the search for new, more effective, and safe drugs. Sulfonamides are the classic group of chemotherapeutic drugs with a broad spectrum of pharmacological activity. Recent literature reports show that sulfonamide derivatives have anti-tumor activity in vitro and in vivo. The aim of the study was to synthesize a novel 1,2,4-triazine sulfonamide derivative and check its anticancer potenti...
Source: Molecules - April 2, 2021 Category: Chemistry Authors: Agnieszka Gornowicz Anna Szymanowska Mariusz Mojzych Robert Czarnomysy Krzysztof Bielawski Anna Bielawska Tags: Article Source Type: research

Molecules, Vol. 26, Pages 1637: Semi-Synthesis of Small Molecules of Aminocarbazoles: Tumor Growth Inhibition and Potential Impact on p53
mília Sousa The tumor suppressor p53 is inactivated by mutation in approximately 50% of human cancers. Small molecules that bind and stabilize those mutants may represent effective anticancer drugs. Herein, we report the tumor cell growth inhibitory activity of carbazole alkaloids and amino derivatives, as well as their potential activation of p53. Twelve aminocarbazole alkaloids were semi-synthesized from heptaphylline (1), 7-methoxy heptaphylline (2), and 7-methoxymukonal (3), isolated from Clausena harmandiana, using a reductive amination protocol. Naturally-occurring carbazoles 1–3 and their amino derivatives we...
Source: Molecules - March 15, 2021 Category: Chemistry Authors: Solida Long Joana B. Loureiro Carla Carvalho Lu ís Gales Luc ília Saraiva Madalena M. M. Pinto Ploenthip Puthongking Em ília Sousa Tags: Article Source Type: research

Molecules, Vol. 24, Pages 4265: Semi-Synthetic Ingenol Derivative from Euphorbia tirucalli Inhibits Protein Kinase C Isotypes and Promotes Autophagy and S-phase Arrest on Glioma Cell Lines
In this study we assessed the biological and therapeutic effect of ingenol-3-dodecanoate (IngC) on glioma. IngC exhibited dose-time-dependent cytotoxic effects on large panel of glioma cell lines (adult, pediatric cancer cells, and primary cultures), as well as, effectively reduced colonies formation. Nevertheless, it was not been able to attenuate cell migration, invasion, and promote apoptotic effects when administered alone. IngC exposure promoted S-phase arrest associated with p21CIP/WAF1 overexpression and regulated a broad range of signaling effectors related to survival and cell cycle regulation. Moreover, IngC led ...
Source: Molecules - November 21, 2019 Category: Chemistry Authors: Silva Rosa Tansini Martinho Tanuri Evangelista Cruvinel Carloni Lima Pianowski Reis Tags: Article Source Type: research