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Molecules, Vol. 26, Pages 5094: Acanthaster planci Inhibits PCSK9 and Lowers Cholesterol Levels in Rats
In this study, a marine invertebrate Acanthaster planci, was used to investigate its potential in inhibiting PCSK9 and lowering the levels of cholesterols. Cytotoxicity activity of A. planci on human liver HepG2 cells was carried out using the MTS assay. It was found that methanolic extract and fractions did not exhibit cytotoxicity effect on HepG2 cell line with IC50 values of more than 30 µg/mL. A compound deoxythymidine also did not exert any cytotoxicity activity with IC50 value of more than 4 µg/mL. Transient transfection and luciferase assay were conducted to determine the effects of A. planci on the transcriptiona...
Source: Molecules - August 23, 2021 Category: Chemistry Authors: Nurjannatul Naim Kamaruddin Nor Azwin Hajri Yosie Andriani Aina Farahiyah Abdul Manan Tengku Sifzizul Tengku Muhammad Habsah Mohamad Tags: Article Source Type: research
