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Total 26 results found since Jan 2013.

Molecules, Vol. 28, Pages 4381: Natural Bacterial and Fungal Peptides as a Promising Treatment to Defeat Lung Cancer Cells
This article is a literature review of research on compounds of natural origin that can potentially be used as part of NSCLC therapies.
Source: Molecules - May 27, 2023 Category: Chemistry Authors: Kamila Rybczy ńska-Tkaczyk Anna Grenda Anna Jakubczyk Pawe ł Krawczyk Tags: Review Source Type: research

Molecules, Vol. 28, Pages 3228: Therapeutic Potential of Albumin Nanoparticles Encapsulated Visnagin in MDA-MB-468 Triple-Negative Breast Cancer Cells
iah Pooi Ling Mok Breast cancer is among the most recurrent malignancies, and its prevalence is rising. With only a few treatment options available, there is an immediate need to search for better alternatives. In this regard, nanotechnology has been applied to develop potential chemotherapeutic techniques, particularly for cancer therapy. Specifically, albumin-based nanoparticles are a developing platform for the administration of diverse chemotherapy drugs owing to their biocompatibility and non-toxicity. Visnagin, a naturally derived furanochromone, treats cancers, epilepsy, angina, coughs, and inflammatory illnes...
Source: Molecules - April 4, 2023 Category: Chemistry Authors: Abdullah Alsrhani Abozer Y. Elderdery Badr Alzahrani Nasser A. N. Alzerwi Maryam Musleh Althobiti Musaed Rayzah Bandar Idrees Ahmed M. E. Elkhalifa Suresh K. Subbiah Pooi Ling Mok Tags: Article Source Type: research

Molecules, Vol. 28, Pages 1394: Bio-Prospecting of Crude Leaf Extracts from Thirteen Plants of Brazilian Cerrado Biome on Human Glioma Cell Lines
Conclusion: These findings highlight M. chamissois chloroform partition as a promising component and may guide the search for the development of additional new anticancer therapies.
Source: Molecules - February 1, 2023 Category: Chemistry Authors: Silva Rosa Gomes Vital Alves Evangelista Longato Carloni Oliveira Pinto Rom ão Rezende Ara újo Oliveira Souza Oliveira Ribeiro Reis Tags: Article Source Type: research

Molecules, Vol. 28, Pages 750: Molecular Aspects and Therapeutic Implications of Herbal Compounds Targeting Different Types of Cancer
ona Gabriela Bungau Due to genetic changes in DNA (deoxyribonucleic acid) sequences, cancer continues to be the second most prevalent cause of death. The traditional target-directed approach, which is confronted with the importance of target function in healthy cells, is one of the most significant challenges in anticancer research. Another problem with cancer cells is that they experience various mutations, changes in gene duplication, and chromosomal abnormalities, all of which have a direct influence on the potency of anticancer drugs at different developmental stages. All of these factors combine to make cancer med...
Source: Molecules - January 11, 2023 Category: Chemistry Authors: Aditi Sharma Lalit Sharma Shouvik Kumar Nandy Nazrana Payal Shivam Yadav Celia Vargas-De-La-Cruz Md. Khalid Anwer Haroon Khan Tapan Behl Simona Gabriela Bungau Tags: Review Source Type: research

Molecules, Vol. 27, Pages 8504: Metabolite Profiling of Alocasia gigantea Leaf Extract and Its Potential Anticancer Effect through Autophagy in Hepatocellular Carcinoma
. Ghareeb Hepatocellular carcinoma (HCC) is a poor-prognosis type of cancer with high resistance to chemotherapy, making the search for safe drugs a mandatory issue. Plant-derived products have potential to reduce negative side effects of cancer treatments. In this work, ability of a defatted methanolic extract of Alocasia gigantea leaves to fight HCC was evaluated in an animal model. Overall, treatment of HCC-induced mice with the methanolic extract at 150 mg/kg body weight for four consecutive weeks caused induction of autophagy through silencing of the relative expression of autophagy suppressor (mTOR) and inducemen...
Source: Molecules - December 3, 2022 Category: Chemistry Authors: Hend Okasha Tarek Aboushousha Manuel A. Coimbra Susana M. Cardoso Mosad A. Ghareeb Tags: Article Source Type: research

Molecules, Vol. 27, Pages 7915: Bridging the Gap in Malaria Parasite Resistance, Current Interventions, and the Way Forward from in Silico Perspective: A Review
. Soliman The past decade has seen most antimalarial drugs lose their clinical potency stemming from parasite resistance. Despite immense efforts by researchers to mitigate this global scourge, a breakthrough is yet to be achieved, as most current malaria chemotherapies suffer the same fate. Though the etiology of parasite resistance is not well understood, the parasite’s complex life has been implicated. A drug-combination therapy with artemisinin as the central drug, artemisinin-based combination therapy (ACT), is currently the preferred malaria chemotherapy in most endemic zones. The emerging concern o...
Source: Molecules - November 16, 2022 Category: Chemistry Authors: Ransford Oduro Kumi Belinda Oti Nader E. Abo-Dya Mohamed Issa Alahmdi Mahmoud E. S. Soliman Tags: Review Source Type: research

Molecules, Vol. 27, Pages 6847: The Use of Photodynamic Therapy in the Treatment of Brain Tumors & mdash;A Review of the Literature
Molecules, Vol. 27, Pages 6847: The Use of Photodynamic Therapy in the Treatment of Brain Tumors—A Review of the Literature Molecules doi: 10.3390/molecules27206847 Authors: Dorota Bartusik-Aebisher Aleksandra Żołyniak Edyta Barnaś Agnieszka Machorowska-Pieniążek Piotr Oleś Aleksandra Kawczyk-Krupka David Aebisher The treatment of neoplastic disease of the brain is still a challenge for modern medicine. Therefore, advanced methodologies are needed that can rationally and successfully contribute to the early diagnosis of primary and metastatic tumors growing within the brain. Photodynamic...
Source: Molecules - October 13, 2022 Category: Chemistry Authors: Dorota Bartusik-Aebisher Aleksandra Żołyniak Edyta Barna ś Agnieszka Machorowska-Pieni ążek Piotr Ole ś Aleksandra Kawczyk-Krupka David Aebisher Tags: Review Source Type: research

Molecules, Vol. 27, Pages 6032: Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug & mdash;A Review
Molecules, Vol. 27, Pages 6032: Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug—A Review Molecules doi: 10.3390/molecules27186032 Authors: Jun-O Jin Dhananjay Yadav Kajal Madhwani Nidhi Puranik Vishal Chavda Minseok Song Marine natural products are a discerning arena to search for the future generation of medications to treat a spectrum of ailments. Meanwhile, cancer is becoming more ubiquitous over the world, and the likelihood of dying from it is rising. Surgery, radiation, and chemotherapy are the mainstays of cancer treatment worldwide, but their extensive side ef...
Source: Molecules - September 16, 2022 Category: Chemistry Authors: Jun-O Jin Dhananjay Yadav Kajal Madhwani Nidhi Puranik Vishal Chavda Minseok Song Tags: Review Source Type: research

Molecules, Vol. 27, Pages 5714: A Branched and Double Alpha-Gal-Bearing Synthetic Neoglycoprotein as a Biomarker for Chagas Disease
onica Suarez Douglas M. Watts Iliana R. Malo Janine M. Ramsey Belkisyolé Alarcón De Noya Oscar Noya Igor C. Almeida Katja Michael Chagas disease (CD) is caused by the parasite Trypanosoma cruzi and affects 6–7 million people worldwide. The diagnosis is still challenging, due to extensive parasite diversity encompassing seven genotypes (TcI-VI and Tcbat) with diverse ecoepidemiological, biological, and pathological traits. Chemotherapeutic intervention is usually effective but associated with severe adverse events. The development of safer, more effective therapies is hampered by the lack o...
Source: Molecules - September 5, 2022 Category: Chemistry Authors: Alba L. Montoya Elisa G. Carvajal Uriel Ortega-Rodriguez Igor L. Estevao Roger A. Ashmus Sohan R. Jankuru Susana Portillo Cameron C. Ellis Colin D. Knight Julio Alonso-Padilla Luis Izquierdo Maria-Jesus Pinazo Joaquim Gascon Veronica Suarez Douglas M. Wat Tags: Article Source Type: research

Molecules, Vol. 27, Pages 3486: Proapoptotic Effect and Molecular Docking Analysis of Curcumin & ndash;Resveratrol Hybrids in Colorectal Cancer Chemoprevention
Molecules, Vol. 27, Pages 3486: Proapoptotic Effect and Molecular Docking Analysis of Curcumin–Resveratrol Hybrids in Colorectal Cancer Chemoprevention Molecules doi: 10.3390/molecules27113486 Authors: Moreno-Q Herrera-R Yepes Naranjo Cardona-G Different hybrids based on curcumin and resveratrol were previously synthesized and characterized by spectroscopic techniques. The most active molecules (3a, 3e, 3i, and 3k) were evaluated in vitro as an approach to determine the possible mechanism of action of the hybrids. The results indicated that the evaluated curcumin/resveratrol hybrids induce mi...
Source: Molecules - May 28, 2022 Category: Chemistry Authors: Moreno-Q Herrera-R Yepes Naranjo Cardona-G Tags: Article Source Type: research

Molecules, Vol. 27, Pages 2155: Discovery of Cinnamylidene Derivative of Rhodanine with High Anthelmintic Activity against Rhabditis sp.
Żesławska The treatment of parasitic infections requires the application of chemotherapy. In view of increasing resistance to currently in-use drugs, there is a constant need to search for new compounds with anthelmintic activity. A series of 16 cinnamylidene derivatives of rhodanine, including newly synthesized methoxy derivatives (1–11) and previously obtained chloro, nitro, and diethylamine derivatives (12–16), was investigated towards anthelmintic activity. Compounds (1–16) were evaluated against free-living nematodes of the genus Rhabditis sp. In the tested group of rhod...
Source: Molecules - March 27, 2022 Category: Chemistry Authors: Waldemar Tejchman Przemys ław Kołodziej Justyna Kalinowska-T łuścik Wojciech Nitek Grzegorz Żuchowski Anna Bogucka-Kocka Ewa Żesławska Tags: Article Source Type: research

Molecules, Vol. 27, Pages 1414: Drug Repurposing and De Novo Drug Discovery of Protein Kinase Inhibitors as New Drugs against Schistosomiasis
o H. Falcone Schistosomiasis is a neglected tropical disease affecting more than 200 million people worldwide. Chemotherapy relies on one single drug, praziquantel, which is safe but ineffective at killing larval stages of this parasite. Furthermore, concerns have been expressed about the rise in resistance against this drug. In the absence of an antischistosomal vaccine, it is, therefore, necessary to develop new drugs against the different species of schistosomes. Protein kinases are important molecules involved in key cellular processes such as signaling, growth, and differentiation. The kinome of schistosomes has b...
Source: Molecules - February 19, 2022 Category: Chemistry Authors: Bernardo Pereira Moreira Michael H. W. Weber Simone Haeberlein Annika S. Mokosch Bernhard Spengler Christoph G. Grevelding Franco H. Falcone Tags: Review Source Type: research

Molecules, Vol. 27, Pages 1374: The Oxime Ethers with Heterocyclic, Alicyclic and Aromatic Moiety as Potential Anti-Cancer Agents
In this study, 1-(benzofuran-2-yl)ethan-1-one oxime and 26 oxime ethers containing heterocyclic, alicyclic or aromatic moiety were screened for their cytotoxicity against HeLa cancer cell line. The most promising derivatives with potential antitumor activity were 2-(cyclohexylideneaminoxy)acetic acid (18) and (E)-acetophenone O-2-morpholinoethyl oxime (22), which reduced the viability of HeLa cells below 20% of control at concentrations of 100–250 μg/mL. Some oxime ethers, namely thiazole and benzothiophene derivatives (24–27), also reduced HeLa cell viability at similar concentration...
Source: Molecules - February 17, 2022 Category: Chemistry Authors: Tomasz Kosmalski Anna Hetmann Renata Studzi ńska Szymon Baumgart Daria Kupczyk Katarzyna Roszek Tags: Article Source Type: research

Molecules, Vol. 27, Pages 569: In Vitro Evaluation of the Cytotoxic Effect of Streptococcus pyogenes Strains, Protegrin PG-1, Cathelicidin LL-37, Nerve Growth Factor and Chemotherapy on the C6 Glioma Cell Line
nder N. Suvorov Brain cancer treatment, where glioblastoma represents up to 50% of all CNS malignancies, is one of the most challenging calls for neurooncologists. The major driver of this study was a search for new approaches for the treatment of glioblastoma. We tested live S. pyogenes, cathelicidin family peptides and NGF, assessing the oncolytic activity of these compounds as monotherapy or in combination with chemotherapeutics. For cytotoxicity evaluation, we used the MTT assay, trypan blue assay and the xCELLigence system. To evaluate the safety of the studied therapeutic approaches, we performed experiments on n...
Source: Molecules - January 17, 2022 Category: Chemistry Authors: Alexandr N. Chernov Anna Tsapieva Diana A. Alaverdian Tatiana A. Filatenkova Elvira S. Galimova Mariia Suvorova Olga V. Shamova Alexander N. Suvorov Tags: Article Source Type: research

Molecules, Vol. 26, Pages 6929: Antineoplastics Encapsulated in Nanostructured Lipid Carriers
da de Paula Ideally, antineoplastic treatment aims to selectively eradicate cancer cells without causing systemic toxicity. A great number of antineoplastic agents (AAs) are available nowadays, with well-defined therapeutic protocols. The poor bioavailability, non-selective action, high systemic toxicity, and lack of effectiveness of most AAs have stimulated the search for novel chemotherapy protocols, including technological approaches that provide drug delivery systems (DDS) for gold standard medicines. Nanostructured lipid carriers (NLC) are DDS that contain a core of solid and lipid liquids stabilised by surfactant...
Source: Molecules - November 17, 2021 Category: Chemistry Authors: Gustavo Henrique Rodrigues da Silva Ludmilla David de Moura Fab íola Vieira de Carvalho Gabriela Geronimo Talita Cesarim Mendon ça Fernando Freitas de Lima Eneida de Paula Tags: Review Source Type: research