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Source: Molecules

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Total 109 results found since Jan 2013.

Molecules, Vol. 26, Pages 5001: The Nrf2 Pathway in Ischemic Stroke: A Review
ano Saso Ischemic stroke, characterized by the sudden loss of blood flow in specific area(s) of the brain, is the leading cause of permanent disability and is among the leading causes of death worldwide. The only approved pharmacological treatment for acute ischemic stroke (intravenous thrombolysis with recombinant tissue plasminogen activator) has significant clinical limitations and does not consider the complex set of events taking place after the onset of ischemic stroke (ischemic cascade), which is characterized by significant pro-oxidative events. The transcription factor Nuclear factor erythroid 2-related factor...
Source: Molecules - August 18, 2021 Category: Chemistry Authors: Marcelo Farina Leonardo Eug ênio Vieira Brigitta Buttari Elisabetta Profumo Luciano Saso Tags: Review Source Type: research

Molecules, Vol. 24, Pages 793: GC-MS-Based Metabolomics to Reveal the Protective Effect of Gross Saponins of Tribulus terrestris Fruit against Ischemic Stroke in Rat
In this study, the protective effect of GSTTF on ischemic stroke in a middle cerebral artery occlusion (MCAO) rat model was investigated by the GC-MS-based metabolomics approach. 2,3,5-triphenyltetrazolium chloride (TTC) staining of brain tissues showed that GSTTF significantly reduced the infarct area after MCAO surgery. Metabolomic profiling showed a series of metabolic perturbation occurs in ischemic stroke compared with sham group. GSTTF can reverse the MCAO-induced serum metabolic deviations by regulating multiple metabolic pathways including fatty acids metabolism, amino acids metabolism, and carbohydrates metabolism...
Source: Molecules - February 22, 2019 Category: Chemistry Authors: Yang Wang Hongyu Zhao Yue Liu Wenjun Guo Yanru Bao Manqi Zhang Tunhai Xu Shengxu Xie Xinyu Liu Yajuan Xu Tags: Article Source Type: research

Molecules, Vol. 21, Pages 1143: In Vivo Targeted MR Imaging of Endogenous Neural Stem Cells in Ischemic Stroke
Acute ischemic stroke remains a leading cause of death and disability. Endogenous neurogenesis enhanced via activation of neural stem cells (NSCs) could be a promising method for stroke treatment. In vivo targeted tracking is highly desirable for monitoring the dynamics of endogenous NSCs in stroke. Previously, we have successfully realized in vivo targeted MR imaging of endogenous NSCs in normal adult mice brains by using anti-CD15 antibody-conjugated superparamagnetic iron oxide nanoparticles (anti-CD15-SPIONs) as the molecular probe. Herein, we explore the performance of this molecular probe in targeted in vivo tracking...
Source: Molecules - August 28, 2016 Category: Chemistry Authors: Fang Zhang Xiaohui Duan Liejing Lu Xiang Zhang Xiaomei Zhong Jiaji Mao Meiwei Chen Jun Shen Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5783: Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model
ing-Hwa Liu An ischemic stroke is brain damage caused by interruption of blood supply to the brain that can cause death and long-term disability. New medical strategies or therapies are urgently needed for ischemic stroke. Icaritin (ICT) is a metabolite of icariin (ICA), which are two active flavonoid components extracted from Herba epimedii and considered neuroprotective agents in animal models of Alzheimer’s disease and ischemic stroke. The therapeutic effect of ICT on ischemic still remains to be clarified. The aim of this study was to investigate the therapeutic effect of ICT on cerebral ischemia-repe...
Source: Molecules - September 7, 2022 Category: Chemistry Authors: Cheng-Tien Wu Ting-Hua Yang Man-Chih Chen Siao-Syun Guan Chang-Mu Chen Shing-Hwa Liu Tags: Article Source Type: research

Molecules, Vol. 20, Pages 335-347: Anti-Inflammatory Effects of Vinpocetine in Atherosclerosis and Ischemic Stroke: A Review of the Literature
Immune responses play an important role in the pathophysiology of atherosclerosis and ischemic stroke. Atherosclerosis is a common condition that increases the risk of stroke. Hyperlipidemia damages endothelial cells, thus initiating chemokine pathways and the release of inflammatory cytokines—this represents the first step in the inflammatory response to atherosclerosis. Blocking blood flow in the brain leads to ischemic stroke, and deprives neurons of oxygen and energy. Damaged neurons release danger-associated molecular patterns, which promote the activation of innate immune cells and the release of inflammatory cytok...
Source: Molecules - December 26, 2014 Category: Chemistry Authors: Linjie ZhangLi Yang Tags: Review Source Type: research

Molecules, Vol. 27, Pages 5488: The Effect of a New N-hetero Cycle Derivative on Behavior and Inflammation against the Background of Ischemic Stroke
Kiseleva Vadim V. Negrebetsky Yuri I. Baukov Ischemic stroke triggers a whole cascade of pathological changes in the brain, one of which is postischemic inflammation. Since in such cases thrombolytic therapy is often not possible, methods that modulate inflammation and affect microglia become particularly interesting. We synthesized 3-(2-oxo-4-phenylpyrrolidin-1-yl)propane-1-sulfonate calcium(II) (Compound 4) and studied its anti-inflammatory activity in in vitro and in vivo models of inflammation and ischemia. Macrophage cell line RAW 264.7 was treated with lipopolysaccharides (LPS) and Compound 4 at various dosa...
Source: Molecules - August 26, 2022 Category: Chemistry Authors: Denis A. Borozdenko Tatiana A. Shmigol Aiarpi A. Ezdoglian Darya I. Gonchar Natalia. Y. Karpechenko Dmitri N. Lyakhmun Anastasia D. Shagina Elvira A. Cherkashova Daria D. Namestnikova Ilya L. Gubskiy Anastasia A. Chernysheva Nina M. Kiseleva Vadim V. Negr Tags: Article Source Type: research

Molecules, Vol. 27, Pages 3099: The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke
This study aims to update and summarize the signaling pathways and targets of natural compounds in the treatment of IS, and provide a base of information for the future development of effective treatments for IS.
Source: Molecules - May 12, 2022 Category: Chemistry Authors: Xing-Hua Li Feng-Ting Yin Xiao-Hang Zhou Ai-Hua Zhang Hui Sun Guang-Li Yan Xi-Jun Wang Tags: Review Source Type: research

Molecules, Vol. 23, Pages 1406: Dexamethasone-Loaded, PEGylated, Vertically Aligned, Multiwalled Carbon Nanotubes for Potential Ischemic Stroke Intervention
Viness Pillay The complete synthesis, optimization, purification, functionalization and evaluation of vertically aligned multiwalled carbon nanotubes (VA-MWCNTs) was reported for potential application in dexamethasone delivery to the ischemic brain tissue. The conditions for high yield were optimized and carbon nanotubes functionalized and PEGylated prior to dexamethasone loading. Morphological changes were confirmed by SEM and TEM. Addition of functional groups to MWCNTs was demonstrated by FTIR. Thermal stability reduced following MWCNTs functionalization as demonstrated in TGA. The presence of carbon at 2&th...
Source: Molecules - June 10, 2018 Category: Chemistry Authors: Patrick P. Komane Pradeep Kumar Thashree Marimuthu Lisa C. du Toit Pierre P. D. Kondiah Yahya E. Choonara Viness Pillay Tags: Article Source Type: research

Molecules, Vol. 24, Pages 1831: A NMR-Based Metabonomics Approach to Determine Protective Effect of a Combination of Multiple Components Derived from Naodesheng on Ischemic Stroke Rats
This study aimed to investigate the protective effect of the ten-component combination derived from NDS (TCNDS) on ischemic stroke rats with a middle cerebral artery occlusion (MCAO) model by integrating an NMR-based metabonomics approach with biochemical assessment. Our results showed that TCNDS could improve neurobehavioral function, decrease the cerebral infarct area, and ameliorate pathological features in MCAO model rats. In addition, TCNDS was found to decrease plasma lactate dehydrogenase (LDH) and malondialdehyde (MDA) production and increase plasma superoxide dismutase (SOD) production. Furthermore, 1H-NMR metabon...
Source: Molecules - May 12, 2019 Category: Chemistry Authors: Lan Luo Jiazhen Kang Qiong He Yue Qi Xingyu Chen Shumei Wang Shengwang Liang Tags: Article Source Type: research

Molecules, Vol. 27, Pages 1573: Comprehensive Analysis of the Effect of 20(R)-Ginsenoside Rg3 on Stroke Recovery in Rats via the Integrative miRNA & ndash;mRNA Regulatory Network
This study provides new insights into the protective mechanism of 20(R)-Rg3 against CIRI, and the mechanism may be partly associated with the regulation of brain miRNA expression and its target signaling pathways.
Source: Molecules - February 27, 2022 Category: Chemistry Authors: Rui Zhang De-Yun Chen Xing-Wei Luo Yuan Yang Xiao-Chao Zhang Ren-Hua Yang Peng Chen Zhi-Qiang Shen Bo He Tags: Article Source Type: research

Molecules, Vol. 28, Pages 390: Sigma-1 Receptor Activation Improves Oligodendrogenesis and Promotes White-Matter Integrity after Stroke in Mice with Diabetic Mellitus
In this study, C57BL/6 mice were treated with high-fat diets (HFDs) combined with streptozotocin (STZ) injection to mimic type 2 diabetes mellitus (T2DM). Focal cerebral ischemia in T2DM mice was established via injection of the vasoconstrictor peptide endothelin-1 (ET-1) into the hippocampus. Three different treatment plans were used in this study. In one plan, 1 mg/kg of PRE084 (intraperitoneally) was administered for 7 d before ET-1 injection; the mice were sacrificed 24 h after ET-1 injection. In another plan, PRE084 treatment was initiated 24 h after ET-1 injection and lasted for 7 d. In the third plan, PRE084 treatme...
Source: Molecules - January 2, 2023 Category: Chemistry Authors: Wenjing Song Yang Yao Heling Zhang Xin Hao Liping Zhou Zhixiao Song Tiantian Wei Tianyan Chi Peng Liu Xuefei Ji Libo Zou Tags: Article Source Type: research

Molecules, Vol. 26, Pages 5173: Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke
Conclusions: Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.
Source: Molecules - August 26, 2021 Category: Chemistry Authors: Elena A. Tukhovskaya Alina M. Ismailova Elvira R. Shaykhutdinova Gulsara A. Slashcheva Igor A. Prudchenko Inessa I. Mikhaleva Oksana N. Khokhlova Arkady N. Murashev Vadim T. Ivanov Tags: Article Source Type: research

Molecules, Vol. 26, Pages 6365: Lack of Neuroprotective Effects of High-Density Lipoprotein Therapy in Stroke under Acute Hyperglycemic Conditions
Conclusion: We observed a nonsignificant decrease in cerebral infarct size in the HDL group. The deleterious consequences of reperfusion such as hemorrhagic transformation or inflammation were not improved by HDL infusion. In acute hyperglycemia, HDLs are not potent enough to counteract the adverse effects of hyperglycemia. The addition of antioxidants to therapeutic HDLs could improve their neuroprotective capacity.
Source: Molecules - October 21, 2021 Category: Chemistry Authors: David Couret Cynthia Planesse Jessica Patche Nicolas Diotel Brice Nativel Steeve Bourane Olivier Meilhac Tags: Article Source Type: research

Molecules, Vol. 27, Pages 1984: Positive Effect of & alpha;-Asaronol on the Incidence of Post-Stroke Epilepsy for Rat with Cerebral Ischemia-Reperfusion Injury
This study provides valuable data for the follow-up prodrug research of α-asaronol and n-butylphthalide.
Source: Molecules - March 18, 2022 Category: Chemistry Authors: Lan Jiang Xiangnan Hu Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4181: Polyphenols for the Treatment of Ischemic Stroke: New Applications and Insights
Sun Wu Ischemic stroke (IS) is a leading cause of death and disability worldwide. Currently, the main therapeutic strategy involves the use of intravenous thrombolysis to restore cerebral blood flow to prevent the transition of the penumbra to the infarct core. However, due to various limitations and complications, including the narrow time window in which this approach is effective, less than 10% of patients benefit from such therapy. Thus, there is an urgent need for alternative therapeutic strategies, with neuroprotection against the ischemic cascade response after IS being one of the most promising options. I...
Source: Molecules - June 29, 2022 Category: Chemistry Authors: Liu Lin Wang Pan Sun Wu Tags: Review Source Type: research