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Total 27 results found since Jan 2013.

Molecules, Vol. 28, Pages 6424: Green Synthesis of Silver Nanoparticles Derived from Papaver rhoeas L. Leaf Extract: Cytotoxic and Antimicrobial Properties
Beylerli In the last few decades, the search for metal nanoparticles as an alternative to cancer treatments and antibiotics has increased. In this article, the spectroscopic (ultraviolet–visible (UV-vis), electron-dispersing X-ray (EDX), and Fourier transform infrared (FT-IR)), microscopic (field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), and atomic force microscope (AFM)), structural (X-ray diffractometer (XRD) and zetasizer), and analytic (thermogravimetric/differential thermal analyzer (TGA-DTA)) characterization of the silver nanoparticles (AgNPs) produced...
Source: Molecules - September 4, 2023 Category: Chemistry Authors: Polat İpek Re şit Yıldız Mehmet F ırat Baran Abdulkerim Hatipo ğlu Ay şe Baran Albert Sufianov Ozal Beylerli Tags: Article Source Type: research

Molecules, Vol. 28, Pages 928: Design and Synthesis of New Modified Flexible Purine Bases as Potential Inhibitors of Human PNP
Elena Matyugina The great interest in studying the structure of human purine nucleoside phosphorylase (hPNP) and the continued search for effective inhibitors is due to the importance of the enzyme as a target in the therapy of T-cell proliferative diseases. In addition, hPNP inhibitors are used in organ transplant surgeries to provide immunodeficiency during and after the procedure. Previously, we showed that members of the well-known fleximer class of nucleosides are substrates of E. coli PNP. Fleximers have great promise as they have exhibited significant biological activity against a number of viruses of pandemic c...
Source: Molecules - January 17, 2023 Category: Chemistry Authors: Anastasia Khandazhinskaya Ilja Fateev Barbara Eletskaya Anna Maslova Irina Konstantinova Katherine Seley-Radtke Sergey Kochetkov Elena Matyugina Tags: Article Source Type: research

Molecules, Vol. 27, Pages 7694: Natural Hemp-Ginger Extract and Its Biological and Therapeutic Efficacy
This study evaluates the effectiveness of hemp and ginger extract as a supportive treatment for skin diseases. It reports a synergistic effect of hemp and ginger extract. The contents of cannabinoids and components of ginger are determined, with the highest being CBD (587.17 ± 8.32 µg/g) and 6-gingerol (60.07 ± 0.40 µg/g). The minimum inhibitory concentration for Staphylococcus aureus (156.5 µg/mL), Escherichia coli (625.2 µg/mL) and Candida albicans (78.3 µg/mL) was also analyzed. Analysis of WM-266-4 cells revealed the gre...
Source: Molecules - November 9, 2022 Category: Chemistry Authors: Taja Žitek Dragana Bjeli ć Petra Kotnik Andrej Golle Sta ša Jurgec Uro š Potočnik Željko Knez Matja ž Finšgar Ivan Krajnc Igor Krajnc Ma ša Knez Marevci Tags: Article Source Type: research

Molecules, Vol. 27, Pages 7280: Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform
es Andrew Regan Although many antibiotics are active against Gram-positive bacteria, fewer also show activity against Gram-negative bacteria. Here, we present a combination of in silico (electron ion-interaction potential, molecular docking, ADMET), NMR, and microbiological investigations of selected macrolides (14-membered, 15-membered, and 16-membered), aiming to discover the pattern of design for macrolides active against Gram-negative bacteria. Although the conformational studies of 14-membered and 15-membered macrolides are abundant in the literature, 16-membered macrolides, and their most prominent representati...
Source: Molecules - October 26, 2022 Category: Chemistry Authors: Biljana Arsic Jill Barber Ana Cikos Manikandan Kadirvel Emilija Kostic Andrew J. McBain Jelena Milicevic Angela Oates Andrew Regan Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6860: Antimicrobial Activity of Silver and Gold Nanoparticles Prepared by Photoreduction Process with Leaves and Fruit Extracts of Plinia cauliflora and Punica granatum
Courrol The increased number of resistant microbes generates a search for new antibiotic methods. Metallic nanoparticles have emerged as a new platform against several microorganisms. The nanoparticles can damage the bacteria membrane and DNA by oxidative stress. The photoreduction process is a clean and low-cost method for obtaining silver and gold nanoparticles. This work describes two original insights: (1) the use of extracts of leaves and fruits from a Brazilian plant Plinia cauliflora, compared with a well know plant Punica granatum, and (2) the use of phytochemicals as stabilizing agents in the photoreduction pr...
Source: Molecules - October 13, 2022 Category: Chemistry Authors: Marcia Regina Franzolin Daniella dos Santos Courrol Flavia Rodrigues de Oliveira Silva Lilia Coronato Courrol Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6679: Eco-Friendly Synthesis of an Oxovanadium(IV)-bis(abietate) Complex with Antimicrobial Action
uze J. Anaissi The search for less expensive and viable products is always one of the challenges for research development. Commonly, the synthesis of coordination compounds involves expensive ligands, through expensive and low-yield routes, in addition to generating toxic and unusable residues. In this work, the organic ligand used is derived from the resin of a reforestation tree, Pinus elliottii var. elliottii. The synthesis method used Pinus resin and an aqueous solution of vanadium(III) chloride at a temperature of 80 °C. The procedure does not involve organic solvents and does not generate...
Source: Molecules - October 7, 2022 Category: Chemistry Authors: Aline B. Schons Jamille S. Correa Patricia Appelt Daiane Meneguzzi M ário A. A. Cunha Carla Bittencourt Henrique E. Toma Fauze J. Anaissi Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5045: Isolation and Characterization of Galloylglucoses Effective against Multidrug-Resistant Strains of Escherichia coli and Klebsiella pneumoniae
Holzgrabe The search for new antibiotics against multidrug-resistant (MDR), Gram-negative bacteria is crucial with respect to filling the antibiotics development pipeline, which is subject to a critical shortage of novel molecules. Screening of natural products is a promising approach for identifying antimicrobial compounds hosting a higher degree of novelty. Here, we report the isolation and characterization of four galloylglucoses active against different MDR strains of E. coli and K. pneumoniae. A crude acetone extract was prepared from Paeonia officinalis Linnaeus leaves, and bioautography-guided isolation of activ...
Source: Molecules - August 8, 2022 Category: Chemistry Authors: Nelson E. Masota Knut Ohlsen Curd Schollmayer Lorenz Meinel Ulrike Holzgrabe Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4861: Biofilm-i: A Platform for Predicting Biofilm Inhibitors Using Quantitative Structure & mdash;Relationship (QSAR) Based Regression Models to Curb Antibiotic Resistance
Molecules, Vol. 27, Pages 4861: Biofilm-i: A Platform for Predicting Biofilm Inhibitors Using Quantitative Structure—Relationship (QSAR) Based Regression Models to Curb Antibiotic Resistance Molecules doi: 10.3390/molecules27154861 Authors: Akanksha Rajput Kailash T. Bhamare Anamika Thakur Manoj Kumar Antibiotic drug resistance has emerged as a major public health threat globally. One of the leading causes of drug resistance is the colonization of microorganisms in biofilm mode. Hence, there is an urgent need to design novel and highly effective biofilm inhibitors that can work either synergisticall...
Source: Molecules - July 29, 2022 Category: Chemistry Authors: Akanksha Rajput Kailash T. Bhamare Anamika Thakur Manoj Kumar Tags: Article Source Type: research

Molecules, Vol. 27, Pages 3762: In Vitro Phytobiological Investigation of Bioactive Secondary Metabolites from the Malus domestica-Derived Endophytic Fungus Aspergillus tubingensis Strain AN103
In this study, 25 endophytic fungal isolates associated with Malus domestica were isolated, grown, and fermented on a solid rice medium. Subsequently, their ethyl acetate crude extracts were pretested for biological activity. One endophytic fungal isolate demonstrated the highest activity and was chosen for further investigation. Based on its phenotypic, ITS ribosomal gene sequences, and phylogenetic characterization, this isolate was identified as Aspergillus tubingensis strain AN103 with the accession number (KR184138). Chemical investigations of its fermented cultures yielded four compounds: Pyranonigrin A ...
Source: Molecules - June 11, 2022 Category: Chemistry Authors: Hassan Mohamed Weaam Ebrahim Mona El-Neketi Mohamed F. Awad Huaiyuan Zhang Yao Zhang Yuanda Song Tags: Article Source Type: research

Molecules, Vol. 27, Pages 2284: Evaluating Tannins and Flavonoids from Traditionally Used Medicinal Plants with Biofilm Inhibitory Effects against MRGN E. coli
In this study, the antimicrobial and anti-biofilm activities of 14 herbal drugs were investigated. Nine of the tested drugs were traditionally used in Europe for treatment of local infections. For comparison, another five drugs monographed in the European Pharmacopoeia were used. Additionally, the total tannin and flavonoid contents of all tested drugs were analyzed. HPLC fingerprints were recorded to obtain further insights into the components of the extracts. The aim of the study was to identify herbal drugs that might be useable for treatment of infectious diseases, even with multidrug resistant E. coli, and to correlat...
Source: Molecules - March 31, 2022 Category: Chemistry Authors: Niclas Neumann Miriam Honke Maria Povydysh Sebastian Guenther Christian Schulze Tags: Article Source Type: research

Molecules, Vol. 26, Pages 7400: Enhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strains
Polrat Wilairatana Henrique D. M. Coutinho Saulo R. Tintino The search for new antibacterial agents has become urgent due to the exponential growth of bacterial resistance to antibiotics. Nitrogen-containing heterocycles such as 1,8-naphthyridine derivatives have been shown to have excellent antimicrobial properties. Therefore, the purpose of this study was to evaluate the antibacterial and antibiotic-modulating activities of 1,8-naphthyridine derivatives against multi-resistant bacterial strains. The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of the following compo...
Source: Molecules - December 6, 2021 Category: Chemistry Authors: Jos é B. de Araújo-Neto Maria M. C. da Silva C ícera D. de M. Oliveira-Tintino I êda M. Begnini Ricardo A. Rebelo Luiz E. da Silva Sandro L. Mireski Michele C. Nasato Maria I. L. Krautler Jaime Ribeiro-Filho Abolghasem Siyadatpanah Polrat Wilairatana Tags: Article Source Type: research

Molecules, Vol. 26, Pages 5768: Bruguiera gymnorhiza (L.) Lam. at the Forefront of Pharma to Confront Zika Virus and Microbial Infections —An In Vitro and In Silico Perspective
Molecules, Vol. 26, Pages 5768: Bruguiera gymnorhiza (L.) Lam. at the Forefront of Pharma to Confront Zika Virus and Microbial Infections—An In Vitro and In Silico Perspective Molecules doi: 10.3390/molecules26195768 Authors: Nabeelah Bibi Sadeer Juliano G. Haddad Mohammed Oday Ezzat Philippe Desprès Hassan H. Abdallah Gokhan Zengin Ahmet Uysal Chaker El Kalamouni Monica Gallo Domenico Montesano Mohamad Fawzi Mahomoodally The recent emergence of Zika virus (ZIKV) in Brazil and the increasing resistance developed by pathogenic bacteria to nearly all existing antibiotics should be taken as a wa...
Source: Molecules - September 23, 2021 Category: Chemistry Authors: Nabeelah Bibi Sadeer Juliano G. Haddad Mohammed Oday Ezzat Philippe Despr ès Hassan H. Abdallah Gokhan Zengin Ahmet Uysal Chaker El Kalamouni Monica Gallo Domenico Montesano Mohamad Fawzi Mahomoodally Tags: Article Source Type: research

Molecules, Vol. 26, Pages 984: Ultrasound-Assisted Extraction of Anthocyanins Using Natural Deep Eutectic Solvents and Their Incorporation in Edible Films
ordano Extracts rich in bioactive compounds added to edible films have allowed the development of active packaging that increases the shelf life of food. However, it is necessary to search for solvents that are nontoxic and not harmful to the environment, with natural deep eutectic solvents (NADES) being an attractive and easily synthesized alternative. This research aimed to design NADES by lyophilization to be used in the extraction of anthocyanins from the Chilean Luma chequen (Molina) A. Gray berry, and subsequently adding them to the matrix of edible ƙ-carrageenan films. For this purpose, ultrasound-assisted extr...
Source: Molecules - February 12, 2021 Category: Chemistry Authors: Patricia Vel ásquez Daniela Bustos Gloria Montenegro Ady Giordano Tags: Article Source Type: research

Molecules, Vol. 25, Pages 5701: Antimicrobial Activity and Barrier Properties against UV Radiation of Alkaline and Enzymatically Treated Linen Woven Fabrics Coated with Inorganic Hybrid Material
Jesionowski One of the directions of development in the textiles industry is the search for new technologies for producing modern multifunctional products. New solutions are sought to obtain materials that will protect humans against the harmful effects of the environment, including such factors as the activity of microorganisms and UV radiation. Products made of natural cellulose fibers are often used. In the case of this type of material, it is very important to perform appropriate pretreatment before subsequent technological processes. This treatment has the aim of removing impurities from the surface of the fibers,...
Source: Molecules - December 3, 2020 Category: Chemistry Authors: Joanna Olczyk Jadwiga S ójka-Ledakowicz Anetta Walawska Anna Antecka Katarzyna Siwi ńska-Ciesielczyk Jakub Zdarta Teofil Jesionowski Tags: Article Source Type: research

Molecules, Vol. 25, Pages 3503: Evaluation of 1,2-Benzothiazine 1,1-dioxide Derivatives In Vitro Activity towards Clinical-Relevant Microorganisms and Fibroblasts
F. Junka The global concern related with growing number of bacterial pathogens, resistant to numerous antibiotics, prone scientific environment to search for new antimicrobials. Antiseptics appear to be suitable candidates as adjunctive agents to antibiotics or alternative local treatment option aiming to prevent and treat infections. 1,2-benzothiazines are considered one the most promising of them. In this research twenty 1,2-benzothiazine 1,1-dioxide derivatives were scrutinized with regard to their biological activity. Three of them are new. For evaluation of compounds’ activity against microbial path...
Source: Molecules - July 30, 2020 Category: Chemistry Authors: Ruth K. Dudek-Wicher Berenika M. Szcz ęśniak-Sięga Rafa ł J. Wiglusz Jan Janczak Marzenna Bartoszewicz Adam F. Junka Tags: Article Source Type: research