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Source: Expert Review of Neurotherapeutics
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Developing precision treatments for epilepsy using patient and animal models
Expert Rev Neurother. 2020 Dec 29:1-10. doi: 10.1080/14737175.2021.1866989. Online ahead of print.ABSTRACTIntroduction: Phenytoin was the first antiepileptic drug (AED) discovered in an animal model of seizures whose clinical efficacy was subsequently confirmed. This clearly indicated that a search for other AEDs had to consider animal studies. Areas covered: Main seizure tests used for the evaluation of possible anticonvulsive activity of potential anticonvulsants and their predictive values have been reviewed. Procedures used for the estimation of antiepileptogenic effects have been also included. Expert opinion: First-l...
Source: Expert Review of Neurotherapeutics - December 19, 2020 Category: Neurology Authors: Krzysztof Łukawski Stanis ław J Czuczwar Source Type: research
