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Source: Expert Review of Neurotherapeutics

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Total 10669 results found since Jan 2013.

Developing precision treatments for epilepsy using patient and animal models
Expert Rev Neurother. 2020 Dec 29:1-10. doi: 10.1080/14737175.2021.1866989. Online ahead of print.ABSTRACTIntroduction: Phenytoin was the first antiepileptic drug (AED) discovered in an animal model of seizures whose clinical efficacy was subsequently confirmed. This clearly indicated that a search for other AEDs had to consider animal studies.Areas covered: Main seizure tests used for the evaluation of possible anticonvulsive activity of potential anticonvulsants and their predictive values have been reviewed. Procedures used for the estimation of antiepileptogenic effects have been also included.Expert opinion: First-lin...
Source: Expert Review of Neurotherapeutics - December 19, 2020 Category: Neurology Authors: Krzysztof Łukawski Stanis ław J Czuczwar Source Type: research

Diagnostic and therapeutic approach to drug-resistant juvenile myoclonic epilepsy
Expert Rev Neurother. 2021 May 25:1-9. doi: 10.1080/14737175.2021.1931126. Online ahead of print.ABSTRACTINTRODUCTION: Juvenile myoclonic epilepsy (JME), also known as Janz syndrome, is a common form of generalized epilepsy of presumed genetic origin representing up to 10% of all epilepsy cases. Despite adequate anti-seizure medication (ASM) treatment, seizures persist in one-third of JME patients.AREAS COVERED: A literature search was conducted using Pubmed search on the topics of drug-resistant JME.EXPERT OPINION: About 30% of JME patients are drug-resistant. Valproate (VPA) is considered the first-choice drug. In women ...
Source: Expert Review of Neurotherapeutics - May 17, 2021 Category: Neurology Authors: Michele Ascoli Giovanni Mastroianni Sara Gasparini Pasquale Striano Vittoria Cianci Sabrina Neri Valentina Bova Anna Mamm ì Antonio Gambardella Angelo Labate Umberto Aguglia Edoardo Ferlazzo Source Type: research

Developing precision treatments for epilepsy using patient and animal models
Expert Rev Neurother. 2020 Dec 29:1-10. doi: 10.1080/14737175.2021.1866989. Online ahead of print.ABSTRACTIntroduction: Phenytoin was the first antiepileptic drug (AED) discovered in an animal model of seizures whose clinical efficacy was subsequently confirmed. This clearly indicated that a search for other AEDs had to consider animal studies.Areas covered: Main seizure tests used for the evaluation of possible anticonvulsive activity of potential anticonvulsants and their predictive values have been reviewed. Procedures used for the estimation of antiepileptogenic effects have been also included.Expert opinion: First-lin...
Source: Expert Review of Neurotherapeutics - December 19, 2020 Category: Neurology Authors: Krzysztof Łukawski Stanis ław J Czuczwar Source Type: research

Diagnostic and therapeutic approach to drug-resistant juvenile myoclonic epilepsy
Expert Rev Neurother. 2021 May 25:1-9. doi: 10.1080/14737175.2021.1931126. Online ahead of print.ABSTRACTINTRODUCTION: Juvenile myoclonic epilepsy (JME), also known as Janz syndrome, is a common form of generalized epilepsy of presumed genetic origin representing up to 10% of all epilepsy cases. Despite adequate anti-seizure medication (ASM) treatment, seizures persist in one-third of JME patients.AREAS COVERED: A literature search was conducted using Pubmed search on the topics of drug-resistant JME.EXPERT OPINION: About 30% of JME patients are drug-resistant. Valproate (VPA) is considered the first-choice drug. In women ...
Source: Expert Review of Neurotherapeutics - May 17, 2021 Category: Neurology Authors: Michele Ascoli Giovanni Mastroianni Sara Gasparini Pasquale Striano Vittoria Cianci Sabrina Neri Valentina Bova Anna Mamm ì Antonio Gambardella Angelo Labate Umberto Aguglia Edoardo Ferlazzo Source Type: research

Developing precision treatments for epilepsy using patient and animal models
Expert Rev Neurother. 2020 Dec 29:1-10. doi: 10.1080/14737175.2021.1866989. Online ahead of print.ABSTRACTIntroduction: Phenytoin was the first antiepileptic drug (AED) discovered in an animal model of seizures whose clinical efficacy was subsequently confirmed. This clearly indicated that a search for other AEDs had to consider animal studies.Areas covered: Main seizure tests used for the evaluation of possible anticonvulsive activity of potential anticonvulsants and their predictive values have been reviewed. Procedures used for the estimation of antiepileptogenic effects have been also included.Expert opinion: First-lin...
Source: Expert Review of Neurotherapeutics - December 19, 2020 Category: Neurology Authors: Krzysztof Łukawski Stanis ław J Czuczwar Source Type: research

Diagnostic and therapeutic approach to drug-resistant juvenile myoclonic epilepsy
Expert Rev Neurother. 2021 May 25:1-9. doi: 10.1080/14737175.2021.1931126. Online ahead of print.ABSTRACTINTRODUCTION: Juvenile myoclonic epilepsy (JME), also known as Janz syndrome, is a common form of generalized epilepsy of presumed genetic origin representing up to 10% of all epilepsy cases. Despite adequate anti-seizure medication (ASM) treatment, seizures persist in one-third of JME patients.AREAS COVERED: A literature search was conducted using Pubmed search on the topics of drug-resistant JME.EXPERT OPINION: About 30% of JME patients are drug-resistant. Valproate (VPA) is considered the first-choice drug. In women ...
Source: Expert Review of Neurotherapeutics - May 17, 2021 Category: Neurology Authors: Michele Ascoli Giovanni Mastroianni Sara Gasparini Pasquale Striano Vittoria Cianci Sabrina Neri Valentina Bova Anna Mamm ì Antonio Gambardella Angelo Labate Umberto Aguglia Edoardo Ferlazzo Source Type: research

Developing precision treatments for epilepsy using patient and animal models
Expert Rev Neurother. 2020 Dec 29:1-10. doi: 10.1080/14737175.2021.1866989. Online ahead of print.ABSTRACTIntroduction: Phenytoin was the first antiepileptic drug (AED) discovered in an animal model of seizures whose clinical efficacy was subsequently confirmed. This clearly indicated that a search for other AEDs had to consider animal studies.Areas covered: Main seizure tests used for the evaluation of possible anticonvulsive activity of potential anticonvulsants and their predictive values have been reviewed. Procedures used for the estimation of antiepileptogenic effects have been also included.Expert opinion: First-lin...
Source: Expert Review of Neurotherapeutics - December 19, 2020 Category: Neurology Authors: Krzysztof Łukawski Stanis ław J Czuczwar Source Type: research

Diagnostic and therapeutic approach to drug-resistant juvenile myoclonic epilepsy
Expert Rev Neurother. 2021 May 25:1-9. doi: 10.1080/14737175.2021.1931126. Online ahead of print.ABSTRACTINTRODUCTION: Juvenile myoclonic epilepsy (JME), also known as Janz syndrome, is a common form of generalized epilepsy of presumed genetic origin representing up to 10% of all epilepsy cases. Despite adequate anti-seizure medication (ASM) treatment, seizures persist in one-third of JME patients.AREAS COVERED: A literature search was conducted using Pubmed search on the topics of drug-resistant JME.EXPERT OPINION: About 30% of JME patients are drug-resistant. Valproate (VPA) is considered the first-choice drug. In women ...
Source: Expert Review of Neurotherapeutics - May 17, 2021 Category: Neurology Authors: Michele Ascoli Giovanni Mastroianni Sara Gasparini Pasquale Striano Vittoria Cianci Sabrina Neri Valentina Bova Anna Mamm ì Antonio Gambardella Angelo Labate Umberto Aguglia Edoardo Ferlazzo Source Type: research

Developing precision treatments for epilepsy using patient and animal models
Expert Rev Neurother. 2020 Dec 29:1-10. doi: 10.1080/14737175.2021.1866989. Online ahead of print.ABSTRACTIntroduction: Phenytoin was the first antiepileptic drug (AED) discovered in an animal model of seizures whose clinical efficacy was subsequently confirmed. This clearly indicated that a search for other AEDs had to consider animal studies.Areas covered: Main seizure tests used for the evaluation of possible anticonvulsive activity of potential anticonvulsants and their predictive values have been reviewed. Procedures used for the estimation of antiepileptogenic effects have been also included.Expert opinion: First-lin...
Source: Expert Review of Neurotherapeutics - December 19, 2020 Category: Neurology Authors: Krzysztof Łukawski Stanis ław J Czuczwar Source Type: research

Diagnostic and therapeutic approach to drug-resistant juvenile myoclonic epilepsy
Expert Rev Neurother. 2021 May 25:1-9. doi: 10.1080/14737175.2021.1931126. Online ahead of print.ABSTRACTINTRODUCTION: Juvenile myoclonic epilepsy (JME), also known as Janz syndrome, is a common form of generalized epilepsy of presumed genetic origin representing up to 10% of all epilepsy cases. Despite adequate anti-seizure medication (ASM) treatment, seizures persist in one-third of JME patients.AREAS COVERED: A literature search was conducted using Pubmed search on the topics of drug-resistant JME.EXPERT OPINION: About 30% of JME patients are drug-resistant. Valproate (VPA) is considered the first-choice drug. In women ...
Source: Expert Review of Neurotherapeutics - May 17, 2021 Category: Neurology Authors: Michele Ascoli Giovanni Mastroianni Sara Gasparini Pasquale Striano Vittoria Cianci Sabrina Neri Valentina Bova Anna Mamm ì Antonio Gambardella Angelo Labate Umberto Aguglia Edoardo Ferlazzo Source Type: research

Developing precision treatments for epilepsy using patient and animal models
Expert Rev Neurother. 2020 Dec 29:1-10. doi: 10.1080/14737175.2021.1866989. Online ahead of print.ABSTRACTIntroduction: Phenytoin was the first antiepileptic drug (AED) discovered in an animal model of seizures whose clinical efficacy was subsequently confirmed. This clearly indicated that a search for other AEDs had to consider animal studies.Areas covered: Main seizure tests used for the evaluation of possible anticonvulsive activity of potential anticonvulsants and their predictive values have been reviewed. Procedures used for the estimation of antiepileptogenic effects have been also included.Expert opinion: First-lin...
Source: Expert Review of Neurotherapeutics - December 19, 2020 Category: Neurology Authors: Krzysztof Łukawski Stanis ław J Czuczwar Source Type: research

Diagnostic and therapeutic approach to drug-resistant juvenile myoclonic epilepsy
Expert Rev Neurother. 2021 May 25:1-9. doi: 10.1080/14737175.2021.1931126. Online ahead of print.ABSTRACTINTRODUCTION: Juvenile myoclonic epilepsy (JME), also known as Janz syndrome, is a common form of generalized epilepsy of presumed genetic origin representing up to 10% of all epilepsy cases. Despite adequate anti-seizure medication (ASM) treatment, seizures persist in one-third of JME patients.AREAS COVERED: A literature search was conducted using Pubmed search on the topics of drug-resistant JME.EXPERT OPINION: About 30% of JME patients are drug-resistant. Valproate (VPA) is considered the first-choice drug. In women ...
Source: Expert Review of Neurotherapeutics - May 17, 2021 Category: Neurology Authors: Michele Ascoli Giovanni Mastroianni Sara Gasparini Pasquale Striano Vittoria Cianci Sabrina Neri Valentina Bova Anna Mamm ì Antonio Gambardella Angelo Labate Umberto Aguglia Edoardo Ferlazzo Source Type: research

Developing precision treatments for epilepsy using patient and animal models
Expert Rev Neurother. 2020 Dec 29:1-10. doi: 10.1080/14737175.2021.1866989. Online ahead of print.ABSTRACTIntroduction: Phenytoin was the first antiepileptic drug (AED) discovered in an animal model of seizures whose clinical efficacy was subsequently confirmed. This clearly indicated that a search for other AEDs had to consider animal studies.Areas covered: Main seizure tests used for the evaluation of possible anticonvulsive activity of potential anticonvulsants and their predictive values have been reviewed. Procedures used for the estimation of antiepileptogenic effects have been also included.Expert opinion: First-lin...
Source: Expert Review of Neurotherapeutics - December 19, 2020 Category: Neurology Authors: Krzysztof Łukawski Stanis ław J Czuczwar Source Type: research

Diagnostic and therapeutic approach to drug-resistant juvenile myoclonic epilepsy
Expert Rev Neurother. 2021 May 25:1-9. doi: 10.1080/14737175.2021.1931126. Online ahead of print.ABSTRACTINTRODUCTION: Juvenile myoclonic epilepsy (JME), also known as Janz syndrome, is a common form of generalized epilepsy of presumed genetic origin representing up to 10% of all epilepsy cases. Despite adequate anti-seizure medication (ASM) treatment, seizures persist in one-third of JME patients.AREAS COVERED: A literature search was conducted using Pubmed search on the topics of drug-resistant JME.EXPERT OPINION: About 30% of JME patients are drug-resistant. Valproate (VPA) is considered the first-choice drug. In women ...
Source: Expert Review of Neurotherapeutics - May 17, 2021 Category: Neurology Authors: Michele Ascoli Giovanni Mastroianni Sara Gasparini Pasquale Striano Vittoria Cianci Sabrina Neri Valentina Bova Anna Mamm ì Antonio Gambardella Angelo Labate Umberto Aguglia Edoardo Ferlazzo Source Type: research

Developing precision treatments for epilepsy using patient and animal models
Expert Rev Neurother. 2020 Dec 29:1-10. doi: 10.1080/14737175.2021.1866989. Online ahead of print.ABSTRACTIntroduction: Phenytoin was the first antiepileptic drug (AED) discovered in an animal model of seizures whose clinical efficacy was subsequently confirmed. This clearly indicated that a search for other AEDs had to consider animal studies.Areas covered: Main seizure tests used for the evaluation of possible anticonvulsive activity of potential anticonvulsants and their predictive values have been reviewed. Procedures used for the estimation of antiepileptogenic effects have been also included.Expert opinion: First-lin...
Source: Expert Review of Neurotherapeutics - December 19, 2020 Category: Neurology Authors: Krzysztof Łukawski Stanis ław J Czuczwar Source Type: research