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Specialty: Stem Cells
Source: Stem Cell Research and Therapy
Therapy: Stem Cell Therapy
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Total 21 results found since Jan 2013.
Circular RNA TTC3 regulates cerebral ischemia-reperfusion injury and neural stem cells by miR-372-3p/TLR4 axis in cerebral infarction
Stroke serves as a prevalent cerebrovascular disorder with severe cerebral ischemia/reperfusion (CIR) injury, in which neural stem cells (NSCs) play critical roles in the recovery of cerebral function. Circula...
Source: Stem Cell Research and Therapy - February 12, 2021 Category: Stem Cells Authors: Bo Yang, Li ’e Zang, Jingwen Cui and Linlin Wei Tags: Research Source Type: research
Exosomal microRNA-22-3p alleviates cerebral ischemic injury by modulating KDM6B/BMP2/BMF axis
Cerebral ischemia-reperfusion (I/R) injury, the most common form of stroke, has high mortality and often brings persistent and serious brain dysfunction among survivors. Administration of adipose-derived mesen...
Source: Stem Cell Research and Therapy - February 5, 2021 Category: Stem Cells Authors: Yamei Zhang, Junying Liu, Mi Su, Xin Wang and Chenchen Xie Tags: Research Source Type: research
Clinical Translation of Cell Therapies in Stroke (CT2S) Checklist —a pragmatic tool to accelerate development of cell therapy products
Cell therapies present an exciting potential but there is a long history of expensive translational failures in stroke research. Researchers engaged in cell therapy research would benefit from a practical fram...
Source: Stem Cell Research and Therapy - January 29, 2021 Category: Stem Cells Authors: Anjali Nagpal, Austin G. Milton, Simon A. Koblar and M. Anne Hamilton-Bruce Tags: Method Source Type: research
Momordica charantia polysaccharides modulate the differentiation of neural stem cells via SIRT1/ Β-catenin axis in cerebral ischemia/reperfusion
Stroke is the leading cause of long-term motor disability and cognitive impairment. Recently, neurogenesis has become an attractive strategy for the chronic recovery of stroke. It is important to understand th...
Source: Stem Cell Research and Therapy - November 16, 2020 Category: Stem Cells Authors: Zhaoli Hu, Fengying Li, Xiaoling Zhou, Feng Zhang, Linyan Huang, Bing Gu, Jiangang Shen and Suhua Qi Tags: Research Source Type: research
miR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2/PGE2 pathway
We have previously verified the beneficial effects of exosomes from endothelial progenitor cells (EPC-EXs) in ischemic stroke. However, the effects of EPC-EXs in hemorrhagic stroke have not been investigated. ...
Source: Stem Cell Research and Therapy - October 26, 2020 Category: Stem Cells Authors: Yuchen Li, Jinju Wang, Shuzhen Chen, Pei Wu, Shancai Xu, Chunlei Wang, Huaizhang Shi and Ji Bihl Tags: Research Source Type: research
Stem cell-based therapies for ischemic stroke: a systematic review and meta-analysis of clinical trials
Recently, extensive researches about stem cell-based therapies for ischemic stroke have been published; our review evaluated the efficacy and safety of stem cell-based therapies for ischemic stroke. Our review...
Source: Stem Cell Research and Therapy - June 26, 2020 Category: Stem Cells Authors: Zhonghao Li, Xiaoke Dong, Min Tian, Chongchong Liu, Kaiyue Wang, Lili Li, Zunjing Liu and Jinmin Liu Tags: Review Source Type: research
Intra-carotid arterial transfusion of circulatory-derived autologous endothelial progenitor cells in rodent after ischemic stroke —evaluating the impact of therapeutic time points on prognostic outcomes
This study tested the optimal time point for left intra-carotid arterial (LICA) administration of circulatory-derived autologous endothelial progenitor cells (EPCs) for improving the outcome in rat after acute...
Source: Stem Cell Research and Therapy - June 5, 2020 Category: Stem Cells Authors: Kun-Chen Lin, Han-Tan Chai, Kuan-Hung Chen, Pei-Hsun Sung, John Y. Chiang, Pei-Lin Shao, Chi-Ruei Huang, Yi-Chen Li, Sheung-Fat Ko and Hon-Kan Yip Tags: Research Source Type: research
Low dose of extracellular vesicles identified that promote recovery after ischemic stroke
Mesenchymal stem cell-derived extracellular vesicles (EVs) are one of the most promising therapeutics in protective and/or regenerative therapy in animal models of stroke using a dose of 100 μg. However, wheth...
Source: Stem Cell Research and Therapy - February 19, 2020 Category: Stem Cells Authors: Laura Otero-Ortega, Fernando Laso-Garc ía, Mari Carmen Gómez-de Frutos, Luke Diekhorst, Arturo Martínez-Arroyo, Elisa Alonso-López, María Laura García-Bermejo, Macarena Rodríguez-Serrano, Mercedes Arrúe-Gonzalo, Exuperio Díez-Tejedor, Blanca Fuen Tags: Research Source Type: research
Systemic conditioned medium treatment from interleukin-1 primed mesenchymal stem cells promotes recovery after stroke
Mesenchymal stem cells (MSCs) hold great potential as a therapy for stroke and have previously been shown to promote recovery in preclinical models of cerebral ischaemia. MSCs secrete a wide range of growth fa...
Source: Stem Cell Research and Therapy - January 21, 2020 Category: Stem Cells Authors: Catriona J. Cunningham, Raymond Wong, Jack Barrington, Sabrina Tamburrano, Emmanuel Pinteaux and Stuart M. Allan Tags: Research Source Type: research
Intravenous delivery of adipose tissue-derived mesenchymal stem cells improves brain repair in hyperglycemic stroke rats
Over 50% of acute stroke patients have hyperglycemia, which is associated with a poorer prognosis and outcome. Our aim was to investigate the impact of hyperglycemia on behavioral recovery and brain repair of ...
Source: Stem Cell Research and Therapy - July 17, 2019 Category: Stem Cells Authors: Mari Carmen G ómez-de Frutos, Fernando Laso-García, Luke Diekhorst, Laura Otero-Ortega, Blanca Fuentes, Jukka Jolkkonen, Olivier Detante, Anaick Moisan, Arturo Martínez-Arroyo, Exuperio Díez-Tejedor and María Gutiérrez-Fernández Tags: Research Source Type: research
Combination therapy of human bone marrow –derived mesenchymal stem cells and minocycline improves neuronal function in a rat middle cerebral artery occlusion model
The positive effects of human bone marrow –derived mesenchymal stem cells (hBM-MSCs) and minocycline on ischemic stroke models have been well described through numerous studies. The aim of this study was to eva...
Source: Stem Cell Research and Therapy - November 9, 2018 Category: Stem Cells Authors: Dong Young Cho and Sin-Soo Jeun Tags: Research Source Type: research
Neural stem cell therapy for subacute and chronic ischemic stroke
Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a worldwide leading c...
Source: Stem Cell Research and Therapy - June 13, 2018 Category: Stem Cells Authors: Austin C. Boese, Quan-Son Eric Le, Dylan Pham, Milton H. Hamblin and Jean-Pyo Lee Tags: Review Source Type: research
Effects of intra-arterial transplantation of adipose-derived stem cells on the expression of netrin-1 and its receptor DCC in the peri-infarct cortex after experimental stroke
Stem cell transplantation has been documented to promote functional recovery in animal models of stroke; however, the underlying mechanisms are not yet fully understood. As netrin-1 and its receptor deleted in...
Source: Stem Cell Research and Therapy - October 10, 2017 Category: Stem Cells Authors: Huan Huang, Fan Lin, Jingjing Jiang, Yan Chen, Ainong Mei and Pengli Zhu Tags: Research Source Type: research
Safety and effectiveness of stem cell therapies in early-phase clinical trials in stroke: a systematic review and meta-analysis
Stem cells have demonstrated encouraging potential as reparative therapy for patients suffering from post-stroke disability. Reperfusion interventions in the acute phase of stroke have shown significant benefi...
Source: Stem Cell Research and Therapy - August 30, 2017 Category: Stem Cells Authors: Anjali Nagpal, Fong Chan Choy, Stuart Howell, Susan Hillier, Fiona Chan, Monica A. Hamilton-Bruce and Simon A. Koblar Tags: Review Source Type: research
Preconditioning of bone marrow-derived mesenchymal stromal cells by tetramethylpyrazine enhances cell migration and improves functional recovery after focal cerebral ischemia in rats
Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) is one of the new therapeutic strategies for treating ischemic stroke. However, the relatively poor migratory capacity of BMSCs toward infa...
Source: Stem Cell Research and Therapy - May 12, 2017 Category: Stem Cells Authors: Lin Li, Lisheng Chu, Yan Fang, Yan Yang, Tiebing Qu, Jianping Zhang, Yuanjun Yin and Jingjing Gu Source Type: research
