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SARS-CoV-2 infection increases risk of intracranial hemorrhage
We examined 21 patients suffering from stroke and intracranial hemorrhage (ICH) and 9 (43%) of them were male. We compared relative frequencies using Fisher’s exact test. As we had few observations and many variables, we used principal component analysis (PCA) to reduce data dimensionality. We trained a linear support vector machine (SVM) on the first two PCs of the laboratory data to predict COVID-19.ResultsPatients suffering from stroke had either hypertension or SARS-CoV-2 infection, but seldom both (OR = 0.05, p = 0.0075). The presence of SARS-CoV-2 infection was strongly associated with the logarithm of CRP (p = 1.4...
Source: Frontiers in Human Neuroscience - November 24, 2022 Category: Neuroscience Source Type: research

Neuropsychiatric Symptoms of COVID-19 Explained by SARS-CoV-2 Proteins ’ Mimicry of Human Protein Interactions
Conclusion: SARS-CoV-2-human protein interactions may lead to the development of delirium, psychosis, seizures, encephalitis, stroke, sensory impairments, peripheral nerve diseases, and autoimmune disorders. Our findings are also supported by the previous in vivo and in vitro studies from other viruses. Further in vivo and in vitro studies using the proteins that are pointed here, could pave new targets both for avoiding and reversing neuropsychiatric presentations.
Source: Frontiers in Human Neuroscience - March 23, 2021 Category: Neuroscience Source Type: research