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Geographical variations in left main coronary artery revascularisation: a pre-specified analysis of the EXCEL trial
CONCLUSIONS: In the EXCEL trial, the relative risks for the 30-day and five-year primary composite outcome of death, MI or stroke after PCI versus CABG were consistent irrespective of geography. However, five-year rates of IDR after PCI were significantly higher in NA centres, a finding the Heart Team and patients should consider when making treatment decisions. ClinicalTrials.gov identifier: NCT01205776.PMID:34212863 | DOI:10.4244/EIJ-D-21-00338
Source: EuroIntervention - July 2, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Aung Myat David Hildick-Smith Adam J de Belder Uday Trivedi Aaron Crowley Marie-Claude Morice David E Kandzari Nicholas J Lembo W Morris Brown Patrick W Serruys Arie Pieter Kappetein Joseph F Sabik Gregg W Stone Source Type: research

Clopidogrel Monotherapy in Patients with and without On-Treatment High Platelet Reactivity: a SMART-CHOICE sub-study
CONCLUSIONS: Clopidogrel monotherapy showed treatment effects comparable to DAPT for MACCE in patients with or without HPR. However, HPR was significantly associated with an increased risk of MACCE in clopidogrel-treated patients regardless of maintenance of aspirin.PMID:34031020 | DOI:10.4244/EIJ-D-21-00223
Source: EuroIntervention - May 25, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Seung Hun Lee Sang Yeub Lee Woo Jung Chun Young Bin Song Seung-Hyuk Choi Jin-Ok Jeong Seok Kyu Oh Kyeong Ho Yun Young-Youp Koh Jang-Whan Bae Jae Woong Choi Hyeon-Cheol Gwon Joo-Yong Hahn Source Type: research

A randomized controlled trial to compare the safety and efficacy of sirolimus-eluting biodegradable polymer ultra-thin stent (SUPRAFLEX Cruz) and everolimus-eluting biodegradable polymer stent (SYNERGY) in treatment for three-vessel coronary artery disease: design of the Multivessel TALENT trial.
CONCLUSIONS: The Multivessel TALENT trial will be evaluating a novel treatment strategy for complex coronary artery disease with state-of-the-art PCI based on angiography-derived QFR with novel ultra-thin SUPRAFLEX Cruz stents, compared with the SYNERGY stents. PMID: 32928717 [PubMed - as supplied by publisher]
Source: EuroIntervention - September 18, 2020 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Long-Term Outcomes of In-Stent Restenosis Percutaneous Coronary Intervention among Medicare Beneficiaries.
CONCLUSIONS: ISR PCI was common and associated with significantly higher risk of recurrent long-term major ischemic events compared to patients undergoing de novo lesion PCI. There remains a need for new strategies to minimize ISR. PMID: 32863243 [PubMed - as supplied by publisher]
Source: EuroIntervention - August 31, 2020 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

A Prospective, Multicenter, Randomized, Open-label Trial to Compare Efficacy and Safety of Clopidogrel vs. Ticagrelor in Stabilized Patients with Acute Myocardial Infarction after Percutan eous Coronary Intervention: rationale and design of the TALOS-AMI trial.
CONCLUSIONS: The TALOS-AMI trial is the first large-scale, multicenter, randomized study exploring the efficacy and safety of the de-escalating antiplatelet therapy that switches ticagrelor to clopidogrel in stabilized AMI patients undergoing PCI. PMID: 32718912 [PubMed - as supplied by publisher]
Source: EuroIntervention - July 30, 2020 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Cardiovascular mortality and morbidity in patients undergoing percutaneous coronary intervention after out-of-hospital cardiac arrest: a systematic review and meta-analysis.
CONCLUSIONS: Almost one third of OHCA patients undergoing PCI die and more than one third of the fatalities are attributable to cardiovascular causes. The burden of ischemic and bleeding complications was consistently higher and the success rates of PCI lower among OHCA as compared to non-OHCA patients. PMID: 32624462 [PubMed - as supplied by publisher]
Source: EuroIntervention - July 7, 2020 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Fractional Flow Reserve-Guided Multivessel Angioplasty in Myocardial Infarction: 3-year follow-up with cost benefit analysis of the Compare-Acute trial.
CONCLUSIONS: In patients with STEMI and MVD, FFR-guided complete revascularization is more beneficial in terms of outcome and health-care costs compared to IRA-only revascularization at 36 months. PMID: 32250250 [PubMed - as supplied by publisher]
Source: EuroIntervention - April 8, 2020 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Clinical outcomes of PCI with rotational atherectomy: the European multicentre Euro4C registry.
CONCLUSIONS: Despite the high level of complexity of the studied population, RA turned out to be an effective procedure with a low rate of in-hospital complications and demonstrated good immediate and mid-term results. PMID: 32250249 [PubMed - as supplied by publisher]
Source: EuroIntervention - April 8, 2020 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Procedural Characteristics and Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention for Left Main Trifurcation Disease: The EXCEL trial.
CONCLUSIONS: Despite the greater inherent complexity, procedural and long-term clinical outcomes following PCI of distal LM trifurcations with everolimus-eluting stents in a modest-sized cohort from the EXCEL trial were similar compared with treatment of distal LM bifurcation disease without trifurcations. These findings support PCI as a treatment strategy for selected patients with distal LM trifurcation disease. PMID: 31793882 [PubMed - as supplied by publisher]
Source: EuroIntervention - December 5, 2019 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Influence of Final Kissing Balloon Inflation on Long-term Outcomes After PCI of Distal Left Main Bifurcation Lesions: Analysis From the EXCEL Trial.
CONCLUSIONS: In the EXCEL trial, the performance of FKBI after PCI of distal LM bifurcation lesions was not associated with improved 4-year clinical outcomes regardless of whether 1 stent or ≥2 stents were implanted. PMID: 31763982 [PubMed - as supplied by publisher]
Source: EuroIntervention - November 27, 2019 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Treatment with a dedicated bifurcation sirolimus-eluting cobalt-chromium stent for distal left main coronary artery disease: rationale and design of the POLBOS LM study.
CONCLUSION: The POLBOS LM study will indicate the efficacy of BiOSS LIM C stent with contemporary PCI for distal left main bifurcation lesions in comparison with the XIENCE stent from the recent EXCEL trial, as a performance index. PMID: 31543500 [PubMed - as supplied by publisher]
Source: EuroIntervention - September 24, 2019 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

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