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Comparative Analysis of Cerebrovascular Events in Transcatheter and Surgical Aortic Valve Replacement- Systematic Review and Meta-analysis of Randomized Trials.
CONCLUSIONS: In our meta-analysis of RCTs comparing TAVR and SAVR, we show comparable risk of major stroke, all stroke and all cerebrovascular events. PMID: 29437037 [PubMed - as supplied by publisher]
Source: EuroIntervention - February 14, 2018 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Bioprosthetic aortic valve leaflet thrombosis detected by multidetector computed tomography is associated with adverse cerebrovascular events: a meta-analysis of observational studies.
CONCLUSIONS: MDCT-defined LT following ABV replacement is associated with a significantly increased risk of adverse cerebrovascular events. Further prospective studies are required to ascertain whether LT can be prevented or treated with pharmacological strategies. PMID: 29235436 [PubMed - as supplied by publisher]
Source: EuroIntervention - December 15, 2017 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Outcomes of Valve-In-Valve Transcatheter Aortic Valve Replacement in Patients with Failed Bioprosthetic Aortic Valves: Systematic Review and Meta-analysis of Observational Evidence.
CONCLUSIONS: VIV-TAVR appears to be associated with high procedural success rates and low adverse outcomes during the short and mid-term follow-up period. PMID: 32420881 [PubMed - as supplied by publisher]
Source: EuroIntervention - May 19, 2020 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Repositionable Percutaneous Aortic Valve Implantation with the Lotus Valve: 30-Day and 1-Year Outcomes in 250 High-Risk Surgical Patients.
CONCLUSIONS: Lotus Valve implantation produced excellent valve haemodynamics, minimal PVL, sustained significant improvement in functional status, and good clinical outcomes 1 year post-implant. PMID: 28555592 [PubMed - as supplied by publisher]
Source: EuroIntervention - June 1, 2017 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

One-year outcomes of patients with severe aortic stenosis and an STS-PROM of less than three percent in the SURTAVI trial.
CONCLUSIONS: Among patients at intermediate surgical risk but with STS PROM<3%, TAVI may achieve superior clinical outcomes compared to SAVR. These findings support the need for an adequately powered randomized trial to compare TAVI with SAVR in patients at low operative risk. PMID: 29992904 [PubMed - as supplied by publisher]
Source: EuroIntervention - July 12, 2018 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Early Hemodynamic Changes and Long-Term Outcome Of Patients With Severe Low Gradient Aortic Stenosis After Transcatheter Aortic Valve Replacement.
CONCLUSIONS: NFLG-AS was the most prevalent form of LG severe AS and was associated with adequate left ventricular compensation and good prognosis. On the other hand, CLFLG-AS represents the heart-failure with reduced ejection fraction (HFrEF) form of AS and was associated with the worst prognosis, whereas PLFLG-AS represents the heart-failure with preserved ejection fraction (HFpEF) form of AS with intermediary prognosis. Both groups showed early hemodynamic reverse response after TAVR. PMID: 31566569 [PubMed - as supplied by publisher]
Source: EuroIntervention - October 1, 2019 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Clinical Outcomes of TAVI or SAVR in Men and Women with Aortic Stenosis at Intermediate Operative Risk: a post hoc analysis of the randomized SURTAVI trial.
CONCLUSIONS: Aortic valve replacement, either by surgical or transcatheter approach, appears similarly effective and safe for males and females at intermediate surgical risk. Functional status appears to improve most in females after TAVI. PMID: 32715995 [PubMed - as supplied by publisher]
Source: EuroIntervention - July 28, 2020 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Valve-in-valve transcatheter aortic valve implantation versus repeat surgical aortic valve replacement in patients with a failed aortic bioprosthesis
CONCLUSIONS: ViV TAVI was associated with lower in-hospital mortality but higher 30-day and 6-month all-cause readmission. However, there was no difference in risk of in-hospital stroke, post-procedure pacemaker implantation, MACE, and mortality during 30-day and 6-month readmission compared with repeat SAVR, suggesting that ViV TAVI can be performed safely in carefully selected patients.PMID:34521614 | DOI:10.4244/EIJ-D-21-00472
Source: EuroIntervention - September 15, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Monil Majmundar Rajkumar Doshi Ashish Kumar Douglas Johnston James Brockett Anmar Kanaa'N Joseph A Lahorra Lars G Svensson Amar Krishnaswamy Grant W Reed Rishi Puri Samir R Kapadia Ankur Kalra Source Type: research

Cerebral embolic protection during transcatheter heart interventions
EuroIntervention. 2023 Sep 18;19(7):549-570. doi: 10.4244/EIJ-D-23-00166.ABSTRACTStroke remains a devastating complication of transcatheter aortic valve replacement (TAVR), with the incidence of clinically apparent stroke seemingly fixed at around 3% despite TAVR's significant evolution during the past decade. Embolic showers of debris (calcium, atheroma, valve material, foreign material) are captured in the majority of patients who have TAVR using a filter-based cerebral embolic protection device (CEPD). Additionally, in systematic brain imaging studies, the majority of patients receiving TAVR exhibit new cerebral lesions...
Source: EuroIntervention - September 18, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Victor Alfonso Jimenez Diaz Samir R Kapadia Axel Linke Darren Mylotte Alexandra J Lansky Eberhard Grube Magnus Settergren Rishi Puri Source Type: research

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