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Source: European Respiratory Journal

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Total 303 results found since Jan 2013.

Hemodynamic effects of different vasodilators in patients with type II pulmonary hypertension (PH)
Conclusions. Inhaled Iloprost causes favorable changes in preload and afterload of the impaired LV and increases its performance in patients with PH associated with LV systolic dysfunction.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Bautin, A., Tashkhanov, D., Datsenko, S., Fedotov, P., Iakovlev, A., Moiseeva, O., Sitnikova, M. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Effect of pulmonary hemodynamics on the prognosis of patients with emphysematous COPD after LVRS
Conclusion:Impaired cardiac function may have a greater effect on the survival than impaired ventlatory function, and fixed higher Ppa refractory to 100% oxygen may show a poorer prognosis in patients with emphysematous COPD after LVRS.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Shiraishi, M., Yoshida, Y., Matumoto, T., Harada, T., Ishii, H., Fujita, M., Watanabe, K. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Prognostic factors of mortality and cardiovascular outcomes in the tiotropium safety and performance in respimat (TIOSPIR) trial
Conclusions: In TIOSPIR, prognostic factors for CV and all-cause mortality were similar, with greater risk for CV events in patients with CV medication or history (particularly IHD). High MMRC also particularly correlated with fatal CV events. Exacerbations were prognostic for both all-cause and CV death, but not for non-fatal CV events.Funded by Boehringer Ingelheim.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Dahl, R., Dusser, D., Wise, R., Pledger, G., Anzueto, A., Mueller, A., Fowler, A., Calverley, P. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

Medical knowledge level of Roma inmantes
Conclusions. We have noticed that a great part of the subjects did not have basic medical knowledge. We can say that the level of tuition has a direct impact on FEV1. The primary care physician can potentially improve patient outcomes by increasing medical education level, including the recognition of exacerbation, risk factors, signs and symptoms. The format for the delivery of education will vary depending on staff availability and expertise.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Oancea, C., Fira-Mladinescu, O., Marc, M., Decun, C., Iovan, I., Stoia, E., Crisan, A., Tudorache, V. Tags: 12.1 Medical Education, Web and Internet Source Type: research

Clinical factors linked with coronary artery disease in chronic obstructive pulmonary disease (COPD)
Conclusion: Our data showed that hypertension, left heart failure, and lower serum HDL level were independent predictors for the presence of CAD in COPD. FEV1 and triple vessel CAD were independently associated with the survival of the patients with COPD.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Park, J. H., Ahn, Y. H., Ki, S. K., Jung, Y. J., Lee, K. S., Jung, W. Y., Sheen, S. S., Park, K. J. Tags: 5.2 Monitoring Airway Disease Source Type: research

Hemodynamic effects of inhaled fenoterol and ipratropium in patients with obstructive pulmonary diseases
Conclusion: Inhalation of short acting bronchodilators significantly alters cardiac function and may therefore play an important role for the increased cardiovascular risk. This is consistent with previous findings in smaller cohorts mostly using b2-agonists. However, the mechanisms and clinical impact still are unclear. Further studies are necessary to evaluate the value of hemodynamic monitoring and possible relations to clinical outcome parameters.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Trinkmann, F., Klein, J., Michels, J., Borggrefe, M., Saur, J. Tags: 5.2 Monitoring Airway Disease Source Type: research

C-reactive protein: Its correlations with pulmonary function, physical capacity and anthropometric measurements in patients with metabolic syndrome
Conclusions: It was found negative relationships between CRP level with PF and PC. On the contrary, there were positive correlations of CRP with parameters of BC. We think that it can be provided decline in the CRP level and increment in PF improving the functional capacity and body composition with aerobic exercise in patients with MS.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Demirtas, R. N., Bozdemir Ozel, C., Arikan, H., Calik-Kutukcu, E., Saglam, M., Vardar-Yagli, N., Celer, O., Akalin, A., Alatas, F. Tags: 9.2 Physiotherapists Source Type: research

ANCA associated vasculitis - Evaluation of diagnosis, treatment and outcome in a group of 68 patients
Conclusions: Significant differences exist between GPA and MPA at the initial presentation that can predict the evolution of the disease. The management of patients with ANCA-associated vasculitides is difficult and marked by the adverse effects of the therapy.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Belaconi, I., Toma, C., Stancu, S., Dumitrache-Rujinski, S., Tudose, C., Croitoru, A., Grigoriu, L., Leonte, D., Magheran, E., Bogdan, M. Tags: 1.13 Clinical Problems - Other Source Type: research

Right ventricular contractile reserve is markedly impaired and correlates with exercise capacity in pulmonary arterial hypertension: A dobutamine stress echocardiography study
Conclusions: RV contractile reserve can be assessed using DSE and may reveal subclinical RV dysfunction not apparent at rest. A correlation with exercise capacity suggests potential clinical value beyond resting measurements.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Lau, E., Munoz, P., Sharma, T., Choudhary, P., Celermajer, D. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Dobutamine stress for evaluation of right ventricular reserve in pulmonary arterial hypertension
Right ventricular contractile response to pharmacological stress in pulmonary arterial hypertension (PAH) has not been characterised. We evaluated right ventricular contractile reserve in adults with PAH using dobutamine stress echocardiography. 16 PAH patients and 18 age-matched controls underwent low-dose dobutamine stress echocardiography. Contractile reserve was assessed by the change (; peak stress minus rest value) in tricuspid annular plane systolic excursion (TAPSE) and tricuspid annular systolic velocity (S'). A subgroup of 13 PAH patients underwent treadmill cardiopulmonary exercise testing for peak oxygen uptake...
Source: European Respiratory Journal - February 28, 2015 Category: Respiratory Medicine Authors: Sharma, T., Lau, E. M. T., Choudhary, P., Torzillo, P. J., Munoz, P. A., Simmons, L. R., Naeije, R., Celermajer, D. S. Tags: Pulmonary vascular disease Original Articles: Pulmonary vascular diseases Source Type: research

Right ventricular reserve in a piglet model of chronic pulmonary hypertension
Right ventricular (RV) response to exercise or pharmacological stress is not well documented in pulmonary hypertension (PH). We investigated the relationship between RV reserve and ventricular–arterial coupling. Surgical ligation of the left pulmonary artery was performed in 13 Large White piglets (PH group), thereafter weekly embolisations of the right lower lobe were performed for 5 weeks. A control group of six piglets underwent sham procedures. Right heart catheterisation and echocardiography were performed at week 6. Pressure–volume loops were recorded before and after dobutamine infusion. Induction o...
Source: European Respiratory Journal - February 28, 2015 Category: Respiratory Medicine Authors: Guihaire, J., Haddad, F., Noly, P.-E., Boulate, D., Decante, B., Dartevelle, P., Humbert, M., Verhoye, J.-P., Mercier, O., Fadel, E. Tags: Pulmonary vascular disease Original Articles: Pulmonary vascular diseases Source Type: research

{beta}-blockers in pulmonary arterial hypertension: evolving concepts of right heart failure
Current guidelines advise against the use of β-blockers in pulmonary arterial hypertension (PAH) to avoid systemic hypotension [1]. In addition, PAH patients have a fixed stroke volume, and are therefore highly dependent on heart rate to increase their cardiac output [2–4]. Indeed, Provencher et al. [5] showed that withdrawal of β-blockers significantly improved exercise capacity in portopulmonary hypertension. Peacock and Ross [6] described another case of portopulmonary hypertension, in which the use of a β-blocker to treat a supraventricular tachycardia in an already haemodynamically unstable patient was nearly fatal.
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: de Man, F. S., Handoko, M. L. Tags: Pulmonary vascular disease Editorials Source Type: research

Pulmonary vascular resistance and compliance relationship in pulmonary hypertension
Right ventricular adaptation to the increased pulmonary arterial load is a key determinant of outcomes in pulmonary hypertension (PH). Pulmonary vascular resistance (PVR) and total arterial compliance (C) quantify resistive and elastic properties of pulmonary arteries that modulate the steady and pulsatile components of pulmonary arterial load, respectively. PVR is commonly calculated as transpulmonary pressure gradient over pulmonary flow and total arterial compliance as stroke volume over pulmonary arterial pulse pressure (SV/PApp). Assuming that there is an inverse, hyperbolic relationship between PVR and C, recent stud...
Source: European Respiratory Journal - September 30, 2015 Category: Respiratory Medicine Authors: Chemla, D., Lau, E. M. T., Papelier, Y., Attal, P., Herve, P. Tags: Pulmonary vascular disease Series Source Type: research

COPD and risk of cardiovascular disease: A prospective study of 0.5M Chinese adults
Conclusions: COPD was independently associated with an increased risk of CV events. COPD detection and management should be integrated with CV disease risk reduction efforts.(Funded by GSK).
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Kurmi, O., Li, L., Davis, K., Wang, J., Yang, L., Chen, Y., Guo, Y., Bian, Z., Collins, R., Peto, R., Chen, Z. Tags: 6.1 Epidemiology Source Type: research

Unemployment in COPD: Results from the BOLD study
Conclusion: There was substantial variation in employment of COPD-patients, but the overall effect of COPD on unemployment was modest when we adjusted for geography, demographic factors and comorbidities.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Gronseth, R., Erdal, M., Tan, W. C., Gislason, T., Juvekar, S. K., Salvi, S., Koul, P. A., Hafizi, H., Vollmer, W. M., Studnicka, M., Obaseki, D., Buist, A. S., Johannessen, A. Tags: 6.1 Epidemiology Source Type: research