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Source: European Respiratory Journal

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Total 303 results found since Jan 2013.

Cardiovascular (CV) safety of aclidinium bromide/formoterol fumarate fixed dose combination (FDC) in COPD: Pooled analyses of three Phase III studies
ConclusionOverall, both doses of aclidinium/formoterol FDC BID had CV and CBV safety profiles similar to placebo and/or monotherapies.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Donohue, J. F., Bateman, E. D., D'Urzo, A., Shrestha, P., Leselbaum, A., Lei, A. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

Mortality in sarcoidosis, results from one centre, long term observational study
Conclusion:The leading cause of death in sarcoid patients in our Department were cancers, but just as often, sarcoidosis was the underlying cause of death.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Puscinska, E., Nowinski, A., Goljan-Geremek, A., Bednarek, M., Kaminski, D., Kowalska, A., Gorecka, D. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Metabolic diseases in parents and grandparents predict asthma and hay fever in offspring
Conclusion: This is the first study to show that familial cardio-metabolic disease predicts specific asthma phenotypes and hay fever, independent of familial asthma, suggesting that two distinct pathways carry asthma risk across generations, via familial asthma as well as cardio-metabolic disease.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Carsin, A.-E., Svanes, C., Sunyer, J., Dratva, J., Norback, D., Holm, M., Lindberg, E., Benediktsdottir, B., Forsberg, B., Jogi, R., Schlunssen, V., Franklin, K., Gislason, T., Sigsgaard, T., Heinrich, J., Janson, C., Dharmage, S., Johannessen, A., Gomez Tags: 10.1 Respiratory Infections Source Type: research

Cognitive dysfunction is greater in patients hospitalised with COPD exacerbations than with worsening heart failure
ConclusionsHospitalised COPD patients with exacerbations have greater cognitive impairment than those with worsening heart failure. Differences may be explained by greater smoking load and more anxiety and depression.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Bajaj, M., Tappouni, A., Tumilty, M., Dodd, J., Jones, P., Baker, E. Tags: 1.12 Clinical Problems - COPD Source Type: research

Overall and cardiovascular safety of aclidinium bromide in patients with COPD: Results of a pooled analysis
ConclusionsAclidinium has a good safety profile with no evidence of increased CV or cerebrovascular risk compared with placebo.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Chapman, K. R., Beck, E., Alcaide, D., Garcia Gil, E. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

Assessment of public awareness on chronic obstructive pulmonary disease in Slovenia
ConclusionsPublic awareness and knowledge about COPD is low and COPD is not considered as relevant public health problem. Strategies to inform and educate Slovenian public about COPD are urgently needed.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Farkas, J., Lainscak, M. Tags: 1.6 General Practice and Primary Care Source Type: research

Influence of adaptive servoventilation therapy on autonomic function and baroreceptor reflex sensitivity in heart failure patients with Cheyne-Stokes respiration compared to healthy volunteers
Adaptive servoventiation therapy (ASV) is designed to treat hypocapnic central sleep apnoea (Cheyne-Stokes respiration) in heart failure (HF) . It remains unclear whether this therapy increases stroke volume (SV) and if, this is mediated by a decrease in cardiac afterload due to increased parasympathetic nervous activity (PNA) or by a change in baroreceptor reflex sensitivity.12 patients with HF (12 male; 70 ± 9 years; NYHA ≥ II; EF ≤ 45% and Cheyne- Stokes respiration) and 14 healthy volunteers (13 male, 24 ± 4 years, EF ≥ 60%, AHI < 5/h) were ventilated non-invasively for 1 h with ASV (PaceWave&...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Spiesshofer, J., Fox, H., Bitter, T., Heinrich, J., Lehmann, R., Horstkotte, D., Oldenburg, O. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Smoking status, clinical presentation and outcomes in obstructive sleep apnoea
Conclusions. Smoking habits seems to be associated with the severity of OSA and CVS outcomes. These results underline the importance of smoking cessation in the treatment of patients with OSA.Supported by ISCIII grant PI12/02175, SADAR/2013 and SEPAR/2013.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Boldova, A., Carrizo, S., Minchole, E., Moya, V., Forcen, E., Marin, J. M. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Leukotriene B4 as an early predictor of carotid atherosclerosis in patients with obstructive sleep apnea
Conclusion:patients with OSA have elevated levels of leukotriene B4,a marker of inflammation and an independent risk predictor for atherosclerosis reference:Lévy P, Pépin JL,Mach F.Obstructive sleep apnea and atherosclerosis. Prog Cardiovasc Dis. 2009 Mar-Apr;51(5).Polysomnographic data, CA-IMT, CA-luminnal diameter, and LTB4 level in Group 1 &Group II. Group IGroup IIpSnoring index5±0.433±2.82*P>0.05AI0.2±0.712±0.08*P>0.05AHI3.6±4.0251±20.44*P>0.05ODI5.2±2.3.558±15.5*P>0.05Minimal SaO2 during sleep%95.1±2.381.3±4.7*P&g...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Ibrahim, I., Shawky, A., Mansour, Y., Rashed, K., Bahnasy, W., Abd Elaziz, E. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Obstructive sleep apnoea syndrome and a calculation of cardiovascular risk
In conclusion, overall 10-year cardiovascular risk in a Dutch OSAS population is substantial but lower as reported in earlier studies.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Visscher, L., Brusse-Keizer, M. G. J., Eijsvogel, M. M. M. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Recruitment maneuvers in the presence of pulmonary hypertension: Cardiorespiratory effects during experimental acute lung injury
Conclusion- RM did not affect cardiac work and output regardless of conditions. Moreover in concomitant ALI, PHT somehow counteracted the deleterious effects of RM on elastance and SvO2.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Doras, C., Le Guen, M., Petak, F., Habre, W. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Association between coronary artery disease (CAD) and heart failure and age in obstructive sleep apnoea (OSA) patients
Conclusions: Coronary artery disease was frequent in OSA pts (more than 20%). We found strongest association between heart failure and age and CAD in OSA patients.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Plywaczewski, R., Czyzak-Gradkowska, A., Targowska, M., Bielen, P., Sliwinski, P. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Late-breaking abstract: The influence of CPAP-therapy on system inflamation activity in patients with obstructive sleep apnea
Conclusion: Patients with OSA have an increased level of inflammation in their blood plasma. It can be cause of complications in the cardiovascular system. CPAP-therapy has become an important way to prevent acute myocardial infarction, stroke and sudden death during sleep.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Markin, A., Shoykhet, Y., Tseimakh, I. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Afterload reduction governs improvement in RV systolic function and ventriculo-arterial adaptation in patients with pulmonary arterial hypertension (PAH) undergoing rapid dose escalation of treprostinil
Conclusions: Treprostinil primarily exerts its effects by lowering RV afterload (Ea). This effect governs the improvement in RV systolic pump failure and contractile reserve. RV stiffness is related to afterload but unaffected by treprostinil. Thus, small improvements in RVEDV are likely related to a decrease in high baseline preload dependent (heterometric) autoregulation.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Rischard, F., Vanderpool, R., Champion, H., Simon, M., Rischard, M., Jenkins, I., Knoper, S., Hansen, L., Waxman, A. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Cardiac MRI derived right ventriculo-arterial coupling in pulmonary hypertension as a predictor of survival
Conclusion: SV/ESV predicts survival in PH, but does not seem to provide added value over ejection fraction (RVEF) and does not change with specific treatment. Correlation with invasive data is needed to assess if SV/ESV is an accurate reflection of VA coupling.Table1: Age and gender adjusted survival predictors. Abbreviations RVEDVI right ventricular (RV) end diastolic volume index; RVESVI RV end systolic volume index; LVEDVI left ventricular end diastolic volume indexTable2: baseline and follow up CMR variables after minimum of 3 months of therapy (mean ±SD or median (IQR)).
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Brewis, M., Naeije, R., Bellofiore, A., Chesler, N., Peacock, A. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research