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Source: European Respiratory Journal

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Total 303 results found since Jan 2013.

Prognostic value of hemodynamics following treatment initiation in pulmonary arterial hypertension
Conclusions: Stroke volume index and right atrial pressure at first follow-up catheterization were the best hemodynamic predictors of death or transplantation. These variables should be further validated as treatment targets in a prospective study.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Weatherald, J., Adir, Y., Boucly, A., Savale, L., Simonneau, G., Montani, D., Jaïs, X., Humbert, M., Chemla, D., Sitbon, O., Herve, P. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Longitudinal cardiac changes in a SUGEN/Hypoxic Rat Model of Pulmonary Hypertension determined by Cardiac MRI
Conclusion: 5 weeks of SuHx resulted in RV dysfunction and RV hypertrophy. Although RV systolic pressure remained elevated throughout the 8 week study period, RV dysfunction and RV hypertrophy had improved demonstrating adaptive remodelling of the SuHx rat RV to the induced persistent PH.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Jayasekera, G., Wilson, K., Buist, H., Hughes, C., Nilsen, M., Church, C., Gallagher, L., Mullin, J., Maclean, M., Holmes, W., Welsh, D., Peacock, A. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Haemodynamic effects of exercise therapy in stable, optimally treated pulmonary arterial hypertension
Conclusions: Provisional results suggest exercise therapy in PAH has a positive effect on the pressure-flow relationship in the pulmonary circulation, leading to reduced stress on the right ventricle on exertion. This change may improve long term outcomes.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: MacKenzie, A., Ford, J., Jayasekera, G., Crowe, T., Peacock, A., Church, C., Johnson, M. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Right ventricular contractile reserve and pulmonary arterial compliance differentiate PAH patients with long-term survival and therapeutic success
Conclusions: RV contractile reserve and PA compliance differentiates long-term survivors (>10 years of treatment) from short-term survivors (<2 years of treatment) on PAH specific therapy.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Vanderpool, R., Wickstrom, K., Desai, A., Nair, V., Bernardo, R., Rischard, F. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Obstructive sleep apnea and specific cardiovascular outcomes
Conclusion: We have demonstrated a high prevalence OSA in respondents. We noted that arterial hypertension and cor hypertonicum were in correlation with the degree of OSA. History of myocardial infarction and stroke reach their peak in study group with AHI 15–30, although this conditions were much higher present in overall respondents with OSA compered to respondents without OSA. We have confirmed by increasing degree of OSA increases the percentage of specific cardiovascular outcomes.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Sajnic, A., Trupkovic, A., Zovko, T., Karabatic, S., Lalic, I., Samarzija, M. Tags: Nurses Source Type: research

Late Breaking Abstract - Balloon Pulmonary Angioplasty for the Treatment of Non Operable Chronic Thromboembolic Pulmonary Hypertension - Initial experience of a Belgian Center
Conclusion: In our cohort, we demonstrated that BPA improves most of the haemodynamics variables, including stroke volume index and pulmonary arterial compliance, without severe adverse events. Further studies for the long term efficacy of BPA are required.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Godinas, L., Lawrence, B., Werner, B., Catharina, B., Mathias, L., Marion, D., Geert, M. Tags: Pulmonary hypertension Source Type: research

Vena cava backflow and right ventricular stiffness in pulmonary arterial hypertension
Vena cava backflow is a well-recognised clinical hallmark of right ventricular failure in pulmonary arterial hypertension (PAH). Backflow may result from tricuspid regurgitation during right ventricular systole or from impaired right ventricular diastolic filling during atrial contraction. Our aim was to quantify the forward and backward flow in the vena cava and to establish the main cause in PAH. In 62 PAH patients, cardiac magnetic resonance measurements provided volumetric flows (mL·s–1) in the superior and inferior vena cava; time integration of flow gave volume. The "backward fraction" was defined as the...
Source: European Respiratory Journal - October 16, 2019 Category: Respiratory Medicine Authors: Marcus, J. T., Westerhof, B. E., Groeneveldt, J. A., Bogaard, H. J., de Man, F. S., Vonk Noordegraaf, A. Tags: Pulmonary vascular disease Original Articles: Pulmonary hypertension Source Type: research

Admission to Intensive Care Unit due to non-traumatic coma: etiology and outcome
Conclusion: Intracerebral hemorrhage was the leading cause of NTC, followed by respiratory failure and sepsis. Acute kidney injury was the best predictor of ICU mortality.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Chrysanthopoulou, E., Karampela, I., Patsilinakou, S., Konstantopoulou, G., Franzeskaki, F., Kontogiorgi, M., Diakaki, C., Theodorakopoulou, M., Tsagkaris, I., Armaganidis, A. Tags: Acute critical care Source Type: research

Characteristics of patients treated with nicotine replacement therapy (NRT) prescribed during hospitalization
Conclusions: The follow-up after discharge in specialized units of tobacco cessation is very low, yet the efficacy of the treatment per year was high.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Perez Morales, M., Espana Dominguez, C., Morales Gonzalez, M., Munoz Ramirez, I., Merino Sanchez, M., Arnedillo Munoz, A. Tags: Tobacco, smoking control and health educ. Source Type: research

30-day Readmissions After Acute Exacerbations of COPD: How Relevant Are Comorbidities?
Conclusions: Cardiovascular diseases were highly prevalent and acute heart failure was an important cause of 30-day readmission among AECOPD patients. GERD may complicate AECOPD recovery and patients with previous stroke may be at higher risk of a fatal outcome.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Freitas, C., Dias, J., Leuschner, P. Tags: Monitoring airway disease Source Type: research

Accelerated FEV1 decline and risk of cardiovascular disease and mortality in a primary care population of COPD patients
Accelerated lung function decline has been associated with increased risk of cardiovascular disease (CVD) in a general population, but little is known about this association in chronic obstructive pulmonary disease (COPD). We investigated the association between accelerated lung function decline and CVD outcomes and mortality in a primary care COPD population. COPD patients without a history of CVD were identified in the Clinical Practice Research Datalink (CPRD)-GOLD primary care dataset (n=36 382). Accelerated decline in forced expiratory volume in 1 s (FEV1) was defined using the fastest quartile of the COPD popula...
Source: European Respiratory Journal - March 4, 2021 Category: Respiratory Medicine Authors: Whittaker, H. R., Bloom, C., Morgan, A., Jarvis, D., Kiddle, S. J., Quint, J. K. Tags: COPD and smoking Original Articles: COPD Source Type: research

Lung function and cardiovascular disease: a two-sample Mendelian randomisation study
Conclusion There is strong evidence that reduced FVC is independently and causally associated with coronary artery disease. Although the mechanism remains unclear, FVC could be taken into consideration when assessing cardiovascular risk and considered a potential target for reducing cardiovascular events. FEV1 and airflow obstruction do not appear to cause increased cardiovascular events; confounding and collider bias may explain previous findings of a causal association.
Source: European Respiratory Journal - September 9, 2021 Category: Respiratory Medicine Authors: Higbee, D. H., Granell, R., Sanderson, E., Davey Smith, G., Dodd, J. W. Tags: Genetics Original Articles: Genetics Source Type: research

Acute beat blockade improves right ventricular diastolic filling in pulmonary arterial hypertension: a rodent CMR and clinical human pressure-volume study
Conclusions: Esmolol improves RV diastolic filling in PAH at rest and during low-grade exercise, preserving SV and CO, with energetically favourable effects on contractile efficiency.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Samaranayake, C., Niglas, M., Kempny, A., Baxan, N., Ashek, A., Pinguel, J., Dimopoulos, K., Price, L. C., Wort, S. J., Zhao, L., Mccabe, C. Tags: 13.01 - Pulmonary hypertension Source Type: research

A Novel Anti-Thrombotic, Glenzocimab, in Covid-19 acute respiratory distress syndrome (Cov-ARDS).
Conclusion: The GARDEN study was set up to tackle a global Public Health emergency. Glenzocimab was safe in doses three times higher than used in stroke. Albeit efficacy was not shown, overall, GARDEN provides insights into Cov-ARDS.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Pottecher, J., Sato, V. A. H., Pletan, Y., Comenducci, A., Desort-Henin, V., Jandrot-Perrus, M., Binay, S., Meilhoc, A., Avenard, G. Tags: 02.01 - Acute critical care Source Type: research

Reply: Association between triple therapy and major adverse cardiovascular events in COPD patients
We thank P. Almagro and P. Martinez-Camblor for their interest in our work and for their salient comments. While we agree that there is no universally accepted definition of major adverse cardiovascular event (MACE), the US Food and Drug Administration (FDA) and the European Medicines Agency include nonfatal myocardial infarction and stroke as well as cardiovascular (CV) mortality in their MACE definition [1]. Importantly, this definition includes both haemorrhagic and ischaemic stroke [1–4]. In our study, we followed this classical "three-point" definition of MACE (including haemorrhagic strokes). While this definit...
Source: European Respiratory Journal - March 2, 2023 Category: Respiratory Medicine Authors: Yang, M.-J., Guo, S.-L., Sin, D. D. Tags: Correspondence Source Type: research