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Source: European Respiratory Journal

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Total 303 results found since Jan 2013.

Upfront combination therapy in the treatment of scleroderma-associated pulmonary arterial hypertension: Results of an open label trial
Conclusions: Upfront combination therapy resulted in significant changes in hemodynamics, RV structure and function, and RV-pulmonary vascular coupling as well as functional status at 36 weeks of therapy. When compared to previous clinical trials, these data suggest initial combination therapy is very effective for SSc-PAH.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Hassoun, P., Zamanian, R., Damico, R., Khair, R., Kolb, T., Tedford, R., Hulm, O., Pisanello, C., Sato, T., Corona-Villalobos, C., Zimmerman, S., Gashouta, M., Minai, O., Torres, F., Chin, K., Girgis, R., Mathai, S. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Comparative study about perception of tobacco package disease risk warning and aware COPD among intergenerational/institutional
Conclusion: The results showed that the regardless of age and institutions, imbalance was observed. In addition, health harm of smoke, despite the knowledge of package warning ratio was not unified. This was speculated that the elderly from the youth in Japan were not exposed to anti-tobacco msg and/or were not taught about the harmful. Moreover, we considered important that all risk perceptions will be uniform. Therefore we should do more educate and precaution of Smoking and COPD.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Uno, T. Tags: 6.3 Tobacco, Smoking Control and Health Education Source Type: research

How to follow-up patients with hereditary haemorrhagic telangiectasia and suspected pulmonary arteriovenous malformations
Pulmonary arteriovenous malformations (PAVMs) are abnormal vascular structures that connect one or several pulmonary arteries to one or several pulmonary veins without interposition of a capillary bed, resulting in a right-to-left shunt (RLS) [1]. Over 80% of PAVMs are associated with the genetic disease hereditary haemorrhagic telangiectasia (HHT). The vascular malformations predispose patients to severe complications due to paradoxical systemic emboli of thrombotic or septic origin, such as stroke and brain abscess [2–5]. The treatment of choice for PAVMs is transcatheter embolotherapy, although concerns are emergi...
Source: European Respiratory Journal - May 30, 2016 Category: Respiratory Medicine Authors: Chinet, T. Tags: Interstitial and orphan lung disease, Pulmonary vascular disease Editorials Source Type: research

Perioperative screening for obstructive sleep apnoea and treatment outcomes: where are the data?
Obstructive sleep apnoea (OSA) is common illness found worldwide, with a reported prevalence ranging from 9% to 24% among the general population [1]. In the USA, approximately 92% of women and 82% of men with moderate-to-severe OSA remain undiagnosed [2]. OSA carries several short- and long-term health consequences. These may range from perioperative complications to the risk of having uncontrolled hypertension, stroke, coronary artery disease and dysrhythmias, to name a few [3–8].
Source: European Respiratory Journal - June 29, 2016 Category: Respiratory Medicine Authors: Surani, S. R., Varon, J. Tags: Sleep medicine Editorials Source Type: research

Cardio-metabolic disorder in grandparents associated with asthma in offspring: Results from a European 3-generation analysis
Conclusion: These preliminary results are similar to those observed previously in Northern-Europe. Grand-father CMD was associated with subsequent asthma in offspring independently of a family history of asthma. This may have important implications with regard to public health intervention.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Carsin, A.-E., Real, F., Basagana, X., Accordini, S., Dharmage, S., Schlünssen, V., Benediktsdottir, B., Leynaert, B., Janson, C., Sunyer, J., Dratva, J., Jarvis, D., Svanes, C. Tags: 6.4 Genes and Environment Source Type: research

Ventricular-arterial coupling is preserved during exercise in patients with COPD
COPD is associated with a higher risk of cardiac and vascular disease and an increased risk of cardiovascular (CV) mortality. However, it is unknown whether intrinsic changes to the heart, vasculature or the interaction between these two systems are altered in patients with COPD, especially when the CV system is placed under stress. As such, the aim of this study was to investigate whether ventricular-arterial coupling (arterial elastance [Ea]/end-systolic elastance [Ees]) is altered in COPD patients during exercise. Fifteen COPD patients and 14 healthy age, sex and activity matched controls underwent incremental exercise ...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Eves, N., Gelinas, J. Tags: 4.1 Clinical Physiology, Exercise and Functional Imaging Source Type: research

LATE-BREAKING ABSTRACT: The Sleep Apnea cardioVascular Endpoints (SAVE) study results - A trial of CPAP versus usual care in 2717 high cardiovascular risk patients with moderate-severe obstructive sleep apnea (OSA)
Conclusions: SAVE provides the first definitive randomised controlled trial evidence on the effectiveness of CPAP therapy on future CV events in patients with CV disease and co-occurring OSA.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: McEvoy, R. D., Antic, N., Heeley, E., Luo, Y., Mediano, O., McArdle, N., Tripathi, M., Lorenzi-Filho, G., Zhong, N., Anderson, C. S. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Echocardiography for defining the right ventricular contractile reserve in healthy subjects
Conclusions: These results provide age- and sex-related limits of normal RV contractile reserve as assessed by stress echocardiographic PASP, TAPSE, S and TAPSE/PASP. Right ventricular contractile reserve, however measured, correlates with exercise capacity.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: D'Alto, M., Pavelescu, A., Romeo, E., Argiento, P., Di Marco, G. M., Correra, A., Mattera Iacono, A., Russo, M. G., Naeije, R. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases Source Type: research

MRI derived left atrial volume index predicts treatment response in patients with PAH
Conclusion: This study shows that in patients meeting the haemodynamic criteria for PAH, patients with an elevated LA volume had poor response to PAH therapy. Further work to better characterize this PAH phenotype and recognize the importance of comorbidities in predicting response to therapy is required.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Tubman, E., Sproson, T., Capener, D., Condliffe, R., Elliot, C., Charalampopolous, A., Kiely, D., Jim, W., Swift, A. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases Source Type: research

Does obstructive lung disease impact the survival of patients with obesity-related respiratory failure treated with nocturnal NIV?
Conclusions: For patients with ORRF, the presence of obstructive lung disease does not exert an adverse impact on NIV compliance or survival.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Weerasuriya, C., Wozniak, D., Huq, S., Davies, M. Tags: 2.2 Noninvasive Ventilatory Support Source Type: research

Dietary nitrate supplementation and exercise tolerance in chronic heart failure: A double-blind, randomized, placebo-controlled, crossover trial
Conclusions: Contrary to the hypothesis, 8 days of dietary nitrate supplementation did not enhance skeletal muscle O2 delivery-utilization matching or exercise tolerance in CHF patients. Whether longer treatment duration and/or higher doses are therapeutically effective in this patient population remains to be determined.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Hirai, D., Zelt, J., Jones, J., Bentley, R., Earle, W., Staples, P., Tschakovsky, M., McCans, J., O'Donnell, D., Neder, J. A. Tags: 4.1 Clinical Physiology, Exercise and Functional Imaging Source Type: research

Influence of age, weight and height on oxygen pulse during maximal exercise
Oxygen pulse (O2 pulse) is an important index of cardiovascular efficiency. Low O2 pulse may reflect deconditioning, cardiovascular disease, or exercise limitation. The present study measured the influence of age, weight and height on O2 pulse in 140 Thai adults aged 20 to 78 years old (51 males, 89 females). All subjects underwent cardiopulmonary exercise testing using a treadmill ramp protocol to the symptom-limited maximum. O2 pulse, cardiac output (CO), and stroke volume (SV) at maximal exercise in males were higher than in females by 60%, 70% and 60%, respectively (p<0.001). Linear regression analyses revealed a ne...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Khrisanapant, W., Promsrisuk, T., Pasurivong, O., Boonsawat, W., Patjanasoontorn, B., Benjapornlert, P. Tags: 4.1 Clinical Physiology, Exercise and Functional Imaging Source Type: research

Prevalence of obstructive sleep apnea syndrome (OSAS) in men varies markedly according to definition criteria
Conclusion: Inclusion of co-morbidities in the ICSD-3 criteria does not notably increase OSAS prevalence over that determined by OSA symptoms alone. Better identification of who is at long-term risk from OSA-related complications is needed to define significant OSA.1 Heinzer R, et al. Lancet Resp Med. 2016; 4: e5-e6.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Adams, R., Appleton, S., Vakulin, A., McEvoy, D., Antic, N., Catcheside, P., Taylor, A., Wittert, G. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Response to treatment assessment in patients with PAH by MRI based computational modelling
Conclusion: The non-invasive proposed metrics have the potential to assess the response to PAH therapy, reducing the RHC interventions at follow-up.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Lungu, A., Hose, R., Capener, D., Kiely, D., Wild, J., Swift, A. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases Source Type: research

Survival in patients with IPAH and peak exercise ventilatory limitation
Discussion: These data suggest a negative prognostic impact of VL in IPAH. IPAH patients are classically limited by impaired stroke volume relative to demand but factors affecting exercise ventilatory responses are less understood. Patients with IPAH and VL warrant wider evaluation to understand its long term relevance.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: McCabe, C., Rinaldi, R., Howard, L. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases Source Type: research