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The murky waters of sex differences in post-stroke cognitive impairment
Nature Reviews Neurology, Published online: 15 September 2023; doi:10.1038/s41582-023-00880-5A new study indicates that although men and women are equally likely to experience cognitive impairment after acute ischaemic stroke, there are sex differences in particular cognitive domains. Whether these differences are directly linked to biological sex is uncertain, as many factors, including age and pre-stroke factors, could contribute to cognitive outcomes.
Source: Nature Reviews Neurology - September 15, 2023 Category: Neurology Authors: Louise D. McCullough Source Type: research

The neurovascular unit and systemic biology in stroke — implications for translation and treatment
Nature Reviews Neurology, Published online: 09 September 2022; doi:10.1038/s41582-022-00703-zIn this Review, the authors summarize the interactions of the neurovascular unit with systemic biology after ischaemic stroke, consider how these interactions influence stroke outcome, and discuss how these interactions could be targeted to improve outcomes.
Source: Nature Reviews Neurology - September 9, 2022 Category: Neurology Authors: Steffen Tiedt Alastair M. Buchan Martin Dichgans Ignacio Lizasoain Maria A. Moro Eng H. Lo Source Type: research

Barriers to implementation of evidence into clinical practice in low-resource settings
Nature Reviews Neurology, Published online: 29 June 2022; doi:10.1038/s41582-022-00690-1Low-resource settings lag behind the rest of the world in achieving good health, in part owing to poor translation of clinical evidence into practice. Focusing on neurological disorders — in particular, stroke — this Comment identifies barriers to translation at the individual, provider and health systems levels and proposes theory-driven mitigating solutions.
Source: Nature Reviews Neurology - June 29, 2022 Category: Neurology Authors: Mayowa O. Owolabi Nijasri C. Suwanwela Joseph Yaria Source Type: research

Review and update of the concept of embolic stroke of undetermined source
Nature Reviews Neurology, Published online: 10 May 2022; doi:10.1038/s41582-022-00663-4In this Review, Diener et al. discuss the concept of embolic stroke of undetermined source, proposing updates to the criteria and diagnostic algorithm in light of evidence gathered since the concept was first introduced.
Source: Nature Reviews Neurology - May 10, 2022 Category: Neurology Authors: Hans-Christoph Diener J. Donald Easton Robert G. Hart Scott Kasner Hooman Kamel George Ntaios Source Type: research

New role for enzyme autotaxin in stroke excitotoxicity
Nature Reviews Neurology, Published online: 05 May 2022; doi:10.1038/s41582-022-00666-1A recent paper published in Science Translational Medicine presents evidence for a role of the enzyme autotaxin in excitotoxicity after stroke.
Source: Nature Reviews Neurology - May 5, 2022 Category: Neurology Authors: Sarah Lempri ère Source Type: research

Blood GFAP as an emerging biomarker in brain and spinal cord disorders
Nature Reviews Neurology, Published online: 03 February 2022; doi:10.1038/s41582-021-00616-3In this Review, the authors provide an overview of the evidence regarding the use of blood levels of glial fibrillary acidic protein as a biomarker in a range of neurological diseases, including traumatic brain injury, stroke, multiple sclerosis and Alzheimer disease.
Source: Nature Reviews Neurology - February 3, 2022 Category: Neurology Authors: Ahmed Abdelhak Matteo Foschi Samir Abu-Rumeileh John K. Yue Lucio D ’Anna Andre Huss Patrick Oeckl Albert C. Ludolph Jens Kuhle Axel Petzold Geoffrey T. Manley Ari J. Green Markus Otto Hayrettin Tumani Source Type: research

Pharmacological brain cytoprotection in acute ischaemic stroke — renewed hope in the reperfusion era
Nature Reviews Neurology, Published online: 25 January 2022; doi:10.1038/s41582-021-00605-6In this Review, Fisher and Savitz consider how the era of reperfusion therapy in ischaemic stroke provides new hope for the development of cytoprotective therapies to further improve outcomes, highlighting how promising recent findings can be built on to benefit patients.
Source: Nature Reviews Neurology - January 25, 2022 Category: Neurology Authors: Marc Fisher Sean I. Savitz Source Type: research

Intelligent, mobile stroke imaging
Nature Reviews Neurology, Published online: 21 December 2021; doi:10.1038/s41582-021-00614-5Intelligent, mobile stroke imaging
Source: Nature Reviews Neurology - December 21, 2021 Category: Neurology Authors: Ian Fyfe Source Type: research

Change in stroke outcomes over 20 years
Nature Reviews Neurology, Published online: 20 December 2021; doi:10.1038/s41582-021-00609-2Change in stroke outcomes over 20 years
Source: Nature Reviews Neurology - December 20, 2021 Category: Neurology Authors: Sarah Lempriere Source Type: research

Mobile stroke units can improve stroke outcomes
Nature Reviews Neurology, Published online: 30 September 2021; doi:10.1038/s41582-021-00571-zMobile stroke units can improve stroke outcomes
Source: Nature Reviews Neurology - September 30, 2021 Category: Neurology Authors: Heather Wood Source Type: research

Stroke in Africa: profile, progress, prospects and priorities
Nature Reviews Neurology, Published online: 15 September 2021; doi:10.1038/s41582-021-00542-4In this Review, Akinyemi and colleagues provide an overview of stroke in Africa, including epidemiology, risk factors, genetics and available stroke services. The authors also discuss the future of stroke care in Africa, highlighting the promise of biobanking and novel leadership initiatives.
Source: Nature Reviews Neurology - September 15, 2021 Category: Neurology Authors: Rufus O. Akinyemi Bruce Ovbiagele Olaleye A. Adeniji Fred S. Sarfo Foad Abd-Allah Thierry Adoukonou Okechukwu S. Ogah Pamela Naidoo Albertino Damasceno Richard W. Walker Adesola Ogunniyi Rajesh N. Kalaria Mayowa O. Owolabi Source Type: research

Perinatal stroke: mapping and modulating developmental plasticity
Nature Reviews Neurology, Published online: 14 June 2021; doi:10.1038/s41582-021-00503-xIn this article, Kirton et al. discuss our growing knowledge of the developmental plasticity that occurs after perinatal stroke and highlight the promise of emerging therapies, including non-invasive brain stimulation, brain–computer interfaces and robotics, that aim to modulate that plasticity.
Source: Nature Reviews Neurology - June 14, 2021 Category: Neurology Authors: Adam Kirton Megan J. Metzler Brandon T. Craig Alicia Hilderley Mary Dunbar Adrianna Giuffre James Wrightson Ephrem Zewdie Helen L. Carlson Source Type: research

Is post-stroke cognitive impairment all about real estate?
Nature Reviews Neurology, Published online: 10 June 2021; doi:10.1038/s41582-021-00526-4An international consortium analysis has shown that stroke location strongly predicts post-stroke cognitive impairment, but the effect could be confounded by the characteristics of the infarct and of different patients. Taking pre-stroke cognition and risk factors into consideration might put information about infarct location into a more appropriate context.
Source: Nature Reviews Neurology - June 10, 2021 Category: Neurology Authors: Rebecca F. Gottesman Source Type: research

The African Stroke Organization — a new dawn for stroke in Africa
Nature Reviews Neurology, Published online: 15 January 2021; doi:10.1038/s41582-021-00456-1The African Stroke Organization has been inaugurated as a pan-African coalition of stroke researchers, clinicians, allied health-care professionals, national and regional stroke societies and stroke support organizations in response to the escalating burden of stroke in the continent.
Source: Nature Reviews Neurology - January 15, 2021 Category: Neurology Authors: Rufus O. Akinyemi Michael Brainin Source Type: research

Beyond recanalization — a call for action in acute stroke
Nature Reviews Neurology, Published online: 23 September 2020; doi:10.1038/s41582-020-00417-0Despite the strong treatment effects of mechanical thrombectomy in acute ischaemic stroke, penumbral tissue loss before recanalization and ischaemia–reperfusion injury after diminish functional outcomes and call for adjunct treatments. Classical neuroprotection strategies could consequently be revived, but novel treatment targets are also emerging through mechanistic research.
Source: Nature Reviews Neurology - September 22, 2020 Category: Neurology Authors: Guido Stoll Mirko Pham Source Type: research

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