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Specialty: Cancer & Oncology
Source: Oncotarget

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Total 60 results found since Jan 2013.

Association of SNPs in the TIMP-2 gene and large artery atherosclerotic stroke in southern Chinese Han population.
Authors: Guo T, Hao H, Zhou L, Zhou F, Yu D Abstract Tissue inhibitor of matrix metalloproteinase 2 (TIMP-2) regulates the extracellular matrix degradation, which involved in vascular remodeling and dysfunction, destabilization of atherosclerotic plaque and many other pathological processes. The rupture of atherosclerotic plaque is the trigger of Large artery atherosclerotic (LAA) stroke. We speculate that the Single nucleotide polymorphisms (SNPs) in TIMP-2 may have an association with LAA stroke. To prove this hypothesis, we conducted this case-control study. 250 LAA stroke patients and 250 healthy controls were ...
Source: Oncotarget - February 14, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Clinical significances and features of prompt brain CT scan after intracranial artery stenting: analysis of 501 cases.
Authors: Li J, Cheng SY, Xiong XY, Duan CM, Liu L, Zhou Y, Zhang JR, Wang L, Zhou K, Gong ZL, Liu Y, Wei F, Shuai J, Shen L, Yang QW Abstract Cerebral hemorrhage is a serious complication of intracranial artery stenting that could be fatal without timely identification and treatment. Prompt brain CT scan would help to evaluate whether cerebral hemorrhage occurs, however, the diverse features of the CT scan immediately after stenting could influence the judgement sometimes. Therefore, we analyzed and summarized these features to help to determine the clinical significance of these CT features. The prompt CT features...
Source: Oncotarget - January 28, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Influenza vaccination might reduce the risk of ischemic stroke in patients with atrial fibrillation: A population-based cohort study.
Conclusions: Influenza vaccination might exert a dose-response effect against ischemic stroke in patients with AF who have risk factors for ischemic stroke by reducing the incidence of ischemic stroke, particularly in those aged 65-74 and ≥75 y. PMID: 29348857 [PubMed]
Source: Oncotarget - January 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Ischemic stroke in patients with POEMS syndrome: a case report and comprehensive analysis of literature.
Conclusion: Comprehensive analysis of literature revealed several trends in patients with ischemic stroke and POEMS syndrome including a low survival rate and a preponderance of cerebral vasculopathy and multiple cerebral arteries affected. Ischemic stroke may be a poor outcome predictor in patients with POEMS syndrome. Further researches focusing on a larger cohort may help in better characterizing and treating this rare complication of POEMS syndrome. PMID: 29179528 [PubMed]
Source: Oncotarget - November 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Predictors of hematoma expansion predictors after intracerebral hemorrhage.
Authors: Chen S, Zhao B, Wang W, Shi L, Reis C, Zhang J Abstract Despite years of effort, intracerebral hemorrhage (ICH) remains the most devastating form of stroke with more than 40% 30-day mortality worldwide. Hematoma expansion (HE), which occurs in one third of ICH patients, is strongly predictive of worse prognosis and potentially preventable if high-risk patients were identified in the early phase of ICH. In this review, we summarize data from recent studies on HE prediction and classify those potential indicators into four categories: clinical (severity of consciousness disturbance; blood pressure; blood glu...
Source: Oncotarget - November 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Association analysis of APO gene polymorphisms with ischemic stroke risk: a case-control study in a Chinese Han population.
This study aimed to assess the association of APO gene polymorphisms and ischemic stroke risk in a Chinese Han population. In this case-control study, we genotyped 14 single nucleotide polymorphisms (SNPs) in 3 APO genes in 488 cases and 503 controls using Sequenom Mass-ARRAY technology and evaluated their association with ischemic stroke using the χ2 and genetic model analysis. In the allelic model analysis, we determined three SNPs were significantly associated with ischemic stroke: rs693 with a p value of 0.042 (OR = 1.406; 95%CI = 1.011-1.956), rs651821 with a p value of 0.007 (OR = 0.760; 95%CI = 0.622-0.929) and rs6...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Hepatitis B virus infection and decreased risk of stroke: a meta-analysis.
Authors: Wang Y, Xiong J, Chen X, Niu M, Chen X, Guan Y, Zheng K, Xu K Abstract Several studies have reported that hepatitis B virus (HBV) infection may decrease the risk of stroke. However, its association is controversial. Thus, we conducted a systematic review and meta-analysis to investigate the relationship between hepatitis B virus (HBV) infection and the risk of stroke. Relevant studies published before May 2017 were identified by searching PubMed, EMBASE, and ISI Web of Science. The relationships between HBV infection and the risk of stroke were assessed using odds ratio (OR)/risk ratio (RR) values and the ...
Source: Oncotarget - August 6, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The degradation of mixed lineage kinase domain-like protein promotes neuroprotection after ischemic brain injury.
Authors: Zhou Y, Zhou B, Tu H, Tang Y, Xu C, Chen Y, Zhao Z, Miao Z Abstract Mixed lineage kinase domain-like (MLKL) protein was recently found to play a critical role in necrotic cell death. To explore its role in neurological diseases, we measured MLKL protein expression after ischemia injury in a mouse model. We found that MLKL expression significantly increased 12 h after ischemia/reperfusion (I/R) injury with peak levels at 48 h. Inhibition of MLKL by intraperitoneal administration of NSA significantly reduced infarct volume and improved neurological deficits after 75 min of ischemia and 24 h of reperfusion. F...
Source: Oncotarget - August 4, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Circulating long-chain n-3 polyunsaturated fatty acid and incidence of stroke: a meta-analysis of prospective cohort studies.
CONCLUSIONS: Circulating LC n-3 PUFAs were linearly associated with reduced risk of stroke, especially 22:5n-3 and 22:6n-3. Such findings highlight the importance of circulating LC n-3 PUFA in the development of ischemic stroke. PMID: 28767407 [PubMed - as supplied by publisher]
Source: Oncotarget - August 4, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Predictors of hematoma expansion predictors after intracerebral hemorrhage.
Authors: Chen S, Zhao B, Wang W, Shi L, Reis C, Zhang J Abstract Despite years of effort, intracerebral hemorrhage (ICH) remains the most devastating form of stroke with more than 40% 30-day mortality worldwide. Hematoma expansion (HE), which occurs in one third of ICH patients, is strongly predictive of worse prognosis and potentially preventable if high-risk patients were identified in the early phase of ICH. In this review, we summarize data from recent studies on HE prediction and classify those potential indicators into four categories: clinical (severity of consciousness disturbance; blood pressure; blood glu...
Source: Oncotarget - July 26, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.
We report that co-administration of both drugs exerts a synergistic and additive positive effect on autophagy activity but was cytotoxic to HGPS cells. In contrast, intermittent treatment with lonafarnib followed by sulforaphane separately and in repeated cycles rescued the HGPS cellular phenotype. We propose that intermittent treatment with FTI and SFN separately might be a promising therapeutic avenue for children with HGPS. PMID: 28740020 [PubMed - as supplied by publisher]
Source: Oncotarget - July 26, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Altered resting-state functional activity in isolated pontine infarction patients with pathological laughing and crying.
We examined both the amplitude of low-frequency fluctuation and the regional homogeneity in order to comprehensively evaluate the intrinsic activity in patients with post-stroke pathological laughing and crying. In the post-stroke pathological laughing and crying group, changes in these measures were observed mainly in components of the default mode network (medial prefrontal cortex/anterior cingulate cortex, middle temporal gyrus, inferior temporal gyrus, superior frontal gyrus, middle frontal gyrus and inferior parietal lobule), sensorimotor network (supplementary motor area, precentral gyrus and paracentral lobule), aff...
Source: Oncotarget - July 26, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Antibiotic prophylaxis for infections in patients with acute stroke: a systematic review and meta-analysis of randomized controlled trials.
CONCLUSIONS: Antibiotic prophylaxis can be used to treat the infectious events of acute stroke patients although it has no potential of decreased mortality and improved functional outcome. PMID: 28722662 [PubMed - as supplied by publisher]
Source: Oncotarget - July 21, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Combined renin-angiotensin-aldosterone system blockade and statin therapy effectively reduces the risk of cerebrovascular accident in autosomal dominant polycystic kidney disease: a nationwide population-based cohort study.
In conclusion, ADPKD was associated with an increased risk of CVA occurrence. Combined RAAS blockade and statin therapy effectively reduces the risk of CVA in ADPKD. PMID: 28711910 [PubMed - as supplied by publisher]
Source: Oncotarget - July 18, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Neuroprotective effect of a novel gastrodin derivative against ischemic brain injury: involvement of peroxiredoxin and TLR4 signaling inhibition.
Authors: Mao XN, Zhou HJ, Yang XJ, Zhao LX, Kuang X, Chen C, Liu DL, Du JR Abstract The inhibition of extracellular inflammatory peroxiredoxin (Prx) signaling appears to be a potential therapeutic strategy for neuroinflammatory injury after acute ischemic stroke. Gastrodin (Gas) is a phenolic glycoside that is used for the treatment of cerebral ischemia, accompanied by regulation of the autoimmune inflammatory response. The present study investigated the neuroprotective effects of Gas and its derivative, Gas-D, with a focus on the potential mechanism associated with inflammatory Prx-Toll-like receptor 4 (TLR4) sign...
Source: Oncotarget - July 6, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research