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Specialty: Cancer & Oncology
Source: Oncotarget
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Total 60 results found since Jan 2013.
Changes in the cellular immune system and circulating inflammatory markers of stroke patients.
This study was designed to investigate dynamic changes in the cellular immune system and circulating inflammatory markers after ischemic stroke. Blood was collected from 96 patients and 99 age-matched control subjects for detection of lymphocyte subpopulations and inflammatory markers. We observed decreases in B cells, Th cells, cytotoxic T cells, and NK cells and an increase in regulatory T (Treg) cells in stroke patients on days 1, 3, and 7. Serum levels of TNF-α, C-reactive protein (CRP), IL-4, IL-6, IL-10, IL-17, IL-23, and TGF-β increased, whereas serum level of IFN-γ decreased at all time points after stroke. Stro...
Source: Oncotarget - September 30, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Circulating long-chain n-3 polyunsaturated fatty acid and incidence of stroke: a meta-analysis of prospective cohort studies.
CONCLUSIONS: Circulating LC n-3 PUFAs were linearly associated with reduced risk of stroke, especially 22:5n-3 and 22:6n-3. Such findings highlight the importance of circulating LC n-3 PUFA in the development of ischemic stroke.
PMID: 28767407 [PubMed - as supplied by publisher]
Source: Oncotarget - August 4, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Ischemic stroke in patients with POEMS syndrome: a case report and comprehensive analysis of literature.
Conclusion: Comprehensive analysis of literature revealed several trends in patients with ischemic stroke and POEMS syndrome including a low survival rate and a preponderance of cerebral vasculopathy and multiple cerebral arteries affected. Ischemic stroke may be a poor outcome predictor in patients with POEMS syndrome. Further researches focusing on a larger cohort may help in better characterizing and treating this rare complication of POEMS syndrome.
PMID: 29179528 [PubMed]
Source: Oncotarget - November 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Association analysis of APO gene polymorphisms with ischemic stroke risk: a case-control study in a Chinese Han population.
This study aimed to assess the association of APO gene polymorphisms and ischemic stroke risk in a Chinese Han population. In this case-control study, we genotyped 14 single nucleotide polymorphisms (SNPs) in 3 APO genes in 488 cases and 503 controls using Sequenom Mass-ARRAY technology and evaluated their association with ischemic stroke using the χ2 and genetic model analysis. In the allelic model analysis, we determined three SNPs were significantly associated with ischemic stroke: rs693 with a p value of 0.042 (OR = 1.406; 95%CI = 1.011-1.956), rs651821 with a p value of 0.007 (OR = 0.760; 95%CI = 0.622-0.929) and rs6...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Influenza vaccination might reduce the risk of ischemic stroke in patients with atrial fibrillation: A population-based cohort study.
Conclusions: Influenza vaccination might exert a dose-response effect against ischemic stroke in patients with AF who have risk factors for ischemic stroke by reducing the incidence of ischemic stroke, particularly in those aged 65-74 and ≥75 y.
PMID: 29348857 [PubMed]
Source: Oncotarget - January 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Dietary cholesterol intake and stroke risk: a meta-analysis.
Conclusions: Higher cholesterol intake has no association with the overall stroke risk. Age and body mass index affect the relationship between dietary cholesterol intake and stroke risk. However, the association between higher dietary cholesterol and stroke risk in males remains unclear.
PMID: 29876017 [PubMed]
Source: Oncotarget - June 8, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients.
Authors: Buga AM, Ciobanu O, Bădescu GM, Bogdan C, Weston R, Slevin M, DiNapoli M, Popa-Wagner A
Abstract
Despite the fact that a high proportion of elderly stroke patients develop mood disorders, the mechanisms underlying late-onset neuropsychiatric and neurocognitive symptoms have so far received little attention in the field of neurobiology. In rodents, aged animals display depressive symptoms following stroke, whereas young animals recover fairly well. This finding has prompted us to investigate the expression of serotonin receptors 2A and 2B, which are directly linked to depression, in the brains of aged and ...
Source: Oncotarget - March 27, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
A risk prediction model for post-stroke depression in Chinese stroke survivors based on clinical and socio-psychological features.
CONCLUSION: This study provided an effective risk model for PSD and indicated that the socio-psychological factors were important risk factors of PSD.
PMID: 28446713 [PubMed - as supplied by publisher]
Source: Oncotarget - April 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Association of SNPs in the TIMP-2 gene and large artery atherosclerotic stroke in southern Chinese Han population.
Authors: Guo T, Hao H, Zhou L, Zhou F, Yu D
Abstract
Tissue inhibitor of matrix metalloproteinase 2 (TIMP-2) regulates the extracellular matrix degradation, which involved in vascular remodeling and dysfunction, destabilization of atherosclerotic plaque and many other pathological processes. The rupture of atherosclerotic plaque is the trigger of Large artery atherosclerotic (LAA) stroke. We speculate that the Single nucleotide polymorphisms (SNPs) in TIMP-2 may have an association with LAA stroke. To prove this hypothesis, we conducted this case-control study. 250 LAA stroke patients and 250 healthy controls were ...
Source: Oncotarget - February 14, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Antibiotic prophylaxis for infections in patients with acute stroke: a systematic review and meta-analysis of randomized controlled trials.
CONCLUSIONS: Antibiotic prophylaxis can be used to treat the infectious events of acute stroke patients although it has no potential of decreased mortality and improved functional outcome.
PMID: 28722662 [PubMed - as supplied by publisher]
Source: Oncotarget - July 21, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Hepatitis B virus infection and decreased risk of stroke: a meta-analysis.
Authors: Wang Y, Xiong J, Chen X, Niu M, Chen X, Guan Y, Zheng K, Xu K
Abstract
Several studies have reported that hepatitis B virus (HBV) infection may decrease the risk of stroke. However, its association is controversial. Thus, we conducted a systematic review and meta-analysis to investigate the relationship between hepatitis B virus (HBV) infection and the risk of stroke. Relevant studies published before May 2017 were identified by searching PubMed, EMBASE, and ISI Web of Science. The relationships between HBV infection and the risk of stroke were assessed using odds ratio (OR)/risk ratio (RR) values and the ...
Source: Oncotarget - August 6, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Impact of atrial fibrillation on the development of ischemic stroke among cancer patients classified by CHA2DS2-VASc score-a nationwide cohort study.
Conclusions: The impact of AF on risk of ischemic stroke was attenuated with advancing CHA2DS2-VASc score in patients with cancer.
PMID: 29484138 [PubMed]
Source: Oncotarget - February 28, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Potential specific immunological indicators for stroke associated infection are partly modulated by sympathetic pathway activation.
CONCLUSION: IL-6, IL-10 and HLA-DR are good candidate biomarkers for SAI. The activation of the sympathetic pathway could partly account for the specific immunological alterations found in SAI patients including HLA-DR decrease and IL-10 increase, which both could be reversed by propranolol. However, the mechanism underlying IL-6 increase still needs further exploration.
PMID: 27409177 [PubMed - as supplied by publisher]
Source: Oncotarget - July 15, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Relationship of thyroid function with intracranial arterial stenosis and carotid atheromatous plaques in ischemic stroke patients with euthyroidism.
In conclusion, low free thyroxine levels were independently associated with carotid atheromatous plaques in ischemic stroke patients with euthyroidism, but thyroid function indicators were not associated with intracranial artery stenosis.
PMID: 28147329 [PubMed - as supplied by publisher]
Source: Oncotarget - February 3, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Effect of the asthma-chronic obstructive pulmonary disease syndrome on the stroke, Parkinson's disease, and dementia: a national cohort study.
Conclusions: The ACOS cohort had a higher risk of the neurodegenerative diseases. The lower dose of the inhaler corticosteroids with cumulative dose ≧0.13 gram have the less risk of stroke and dementia.
PMID: 29552322 [PubMed]
Source: Oncotarget - March 20, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
