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Dual effects of the fatty acid receptor ‘GPR40’ for human health
Publication date: Available online 20 January 2015 Source:Progress in Lipid Research Author(s): Tetsumori Yamashima Free fatty acid receptor ‘GPR40’ is expressed predominantly in the wide variety of neurons of the central nervous system and ß-cells in the pancreatic islets. Since its deorphanization in 2003, the past decade has seen major advances in our understanding of its role in insulin secretion. In contrast, there is still a great deal to be learned about the relationship between GPR40 and brain, despite the most abundant mRNA expression. Since GPR40 is expressed also in the hypothalamus, ‘brain-lipid sensin...
Source: Progress in Lipid Research - January 26, 2015 Category: Lipidology Source Type: research

Dual effects of the non-esterified fatty acid receptor ‘GPR40’ for human health
Publication date: Available online 20 January 2015 Source:Progress in Lipid Research Author(s): Tetsumori Yamashima G protein-coupled receptor 40 (GPR40), a receptor for diverse non-esterified fatty acids, is expressed predominantly in the wide variety of neurons of the central nervous system and ß-cells in the pancreatic islets. Since deorphanization of GPR40 in 2003, the past decade has seen major advances in our understanding of its role in the insulin secretion. However, there is still a great deal to be elucidated about the role of GPR40 in the brain, because the latter shows the most abundant GPR40 mRNA expression...
Source: Progress in Lipid Research - January 29, 2015 Category: Lipidology Source Type: research