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Source: Neuroscience Letters
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Total 146 results found since Jan 2013.
Infiltration of invariant natural killer T cells occur and accelerate brain infarction in permanent ischemic stroke in mice
Publication date: 28 October 2016 Source:Neuroscience Letters, Volume 633 Author(s): Zhen-Kui Wang, Li Xue, Tao Wang, Xiu-Jie Wang, Zhi-Qiang Su Invariant natural killer T (iNKT) cells are a unique subset of T cells that have been implicated in inflammation, atopy, autoimmunity, infections, and cancer. Although iNKT cells have been extensively studied over the past decade, its role in the pathogenesis of ischemic brain injury is still largely unknown. In our study, we determined whether iNKT cells infiltration occur in a mouse model of permanent cerebral ischemia. C57BL6/J male mice were treated with either alpha-galactos...
Source: Neuroscience Letters - September 17, 2016 Category: Neuroscience Source Type: research
Repeated misdiagnosis of a relapsed atypical anti-NMDA receptor encephalitis without an associated ovarian teratoma
We present an atypical case of relapsed anti-NMDAR encephalitis in a young female patient without an associated ovarian teratoma. She presented with recurrent seizure attacks with muscle weakness, psychosis, dyskinesia, autonomic failure and insomnia. She was first misdiagnosed as mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) then Hashimoto’s encephalopathy due to diffuse cerebral lesions, elevated serum lactic acid concentration, increased amount of thyroid peroxidase and thyroglobulin antibodies in serum and diffuse lesions of the thyroid gland. Her final diagnosis was delayed fo...
Source: Neuroscience Letters - November 26, 2016 Category: Neuroscience Source Type: research
Experiencing a reaching task passively with one arm while adapting to a visuomotor rotation with the other can lead to substantial transfer of motor learning across the arms
Publication date: 18 January 2017 Source:Neuroscience Letters, Volume 638 Author(s): Shancheng Bao, Yuming Lei, Jinsung Wang The extent of transfer following visuomotor adaptation across the arms is typically limited as compared to that within the same arm. However, we have demonstrated that interlimb transfer can occur nearly completely if one arm performs reaching movements associated with a desired trajectory repeatedly and actively during an initial training session in which the other arm adapts to a novel visuomotor adaptation. Based on that finding, we argued that the absence of instances associated with specific mo...
Source: Neuroscience Letters - December 16, 2016 Category: Neuroscience Source Type: research
Overexpression of Mitofusin2 decreased the reactive astrocytes proliferation in vitro induced by oxygen-glucose deprivation/reoxygenation
This study is to elucidate the role of Mfn2 in reactive astrocytes induced by oxygen-glucose deprivation/reoxygenation(OGD/R) model in vitro. Up-expression in EdU staining and protein level of GFAP, PCNA and CyclinD1, demonstrates the distinct activation and proliferation of astrocytes after the stimulation of OGD/R. Meanwhile, Mfn2 was proved to be down-regulated both in gene and protein levels. Pretreatment of cells with adenoviral vector encoding Mfn2 gene increased Mfn2 expression and subsequently attenuated OGD-induced astrocyte proliferation. Down-regulation of Ras-p-Raf1-p-ERK1/2 pathway and cell cycle arrest were f...
Source: Neuroscience Letters - January 2, 2017 Category: Neuroscience Source Type: research
Mice deficient in L-12/15 lipoxygenase show increased vulnerability to 3-nitropropionic acid neurotoxicity
Publication date: 16 March 2017 Source:Neuroscience Letters, Volume 643 Author(s): Yan He, Rita C. Akumuo, Yuan Yang, Sandra J. Hewett Considerable evidence supports a contributory role for leukocyte-type 12/15 Lipoxygenase (L-12/15 LO) in mediating hippocampal and cortical neuronal injury in models of Alzheimer’s disease and stroke. Whether L-12/15 LO contributes to neuronal injury in a model of Huntington’s disease (HD) has yet to be determined. HD is characterized by marked striatal neuronal loss, which can be mimicked in humans and animals by inhibition of mitochondrial complex II using 3-Nitropropionic acid (3-NP...
Source: Neuroscience Letters - February 19, 2017 Category: Neuroscience Source Type: research
Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains
Publication date: 13 July 2017 Source:Neuroscience Letters, Volume 653 Author(s): Evelina Rekuviene, Laima Ivanoviene, Vilmante Borutaite, Ramune Morkuniene The mitochondrial permeability transition pore (mPTP) is thought to be implicated in brain ischemia-induced cell death. Here we sought to determine whether complex I (CI) of the mitochondrial electron transfer system may be involved in regulation of mPTP opening during ischemia and whether a specific inhibitor of this complex – rotenone can protect against ischemia-induced cell death in an experimental model of total ischemia in adult rat brains. Anesthetized Wistar...
Source: Neuroscience Letters - May 24, 2017 Category: Neuroscience Source Type: research
Rapamycin decreased blood-brain barrier permeability in control but not in diabetic rats in early cerebral ischemia
Publication date: 27 July 2017 Source:Neuroscience Letters, Volume 654 Author(s): Oak Z. Chi, Geza K. Kiss, Scott J. Mellender, Xia Liu, Harvey R. Weiss Diabetes causes functional and structural changes in blood-brain barrier (BBB). The mammalian target of rapamycin (mTOR) has been associated with glucose metabolism, diabetes, and altering BBB permeability. Since there is only a narrow therapeutic window (3h) for stroke victims, it is important to investigate BBB disruption in the early stage of cerebral ischemia. We compared the degree of BBB disruption in diabetic and in control rats at two hours of reperfusion after on...
Source: Neuroscience Letters - June 21, 2017 Category: Neuroscience Source Type: research
Neurovascular toxicity of N-methyl-d-aspartate is markedly enhanced in the developing mouse central nervous system
Publication date: 10 August 2017 Source:Neuroscience Letters, Volume 655 Author(s): Sudhakar Vadivelu, Kui Xu, Vanja Tolj, Rahul Rege, Lindsay Darkins, Karthik Vishwanath Penumbral perfusion is critical to brain viability. Proximal arterial occlusion and deep brain stroke has variable effect on cortical dysfunction. Cortical microvessel collaterals may be recruited and at times sufficient for partial parenchymal perfusion. Postnatal neural and endothelial cells are markedly vulnerable to glutamate excitotoxicity. Early vascular cell stress may promote partial protective neural preconditioning though postnatally a developm...
Source: Neuroscience Letters - July 1, 2017 Category: Neuroscience Source Type: research
The pulvinar nucleus is associated with the presence of dysarthria in patients with basal ganglia hemorrhage
Publication date: 10 August 2017 Source:Neuroscience Letters, Volume 655 Author(s): Dae Hyun Kim, Sunghyon Kyeong, Sung Jun Ahn, Yoon Ghil Park Dysarthria is a frequent symptom in patients with stroke. The anatomical structures responsible for dysarthria have been reported in patients with lacunar infarcts, but the related lesions in patients with basal ganglia hemorrhage (BGH) have not been investigated. The aim of this study was to identify associations between the lesion location and the presence/absence of dysarthria in patients with BGH using voxel-based lesion symptom mapping (VLSM) analyses. A retrospective analysi...
Source: Neuroscience Letters - July 15, 2017 Category: Neuroscience Source Type: research
The protective effect of alpha-lipoic acid against brain ischemia and reperfusion injury via mTOR signaling pathway in rats
In conclusion, we demonstrate the protective effects induced by ALA treatment against the brain I/R injury in rats and mTOR signaling pathway is required for the protective effects of ALA against brain I/R injury. The results might contribute to the potential clinical application of ALA and provide a potential therapeutic target on ischemic stroke.
Source: Neuroscience Letters - February 16, 2018 Category: Neuroscience Source Type: research
Stroke in CNS White Matter: Models and Mechanisms
Publication date: Available online 8 August 2018Source: Neuroscience LettersAuthor(s): Miguel Alejandro Marin, S. Thomas Carmichael
Source: Neuroscience Letters - August 9, 2018 Category: Neuroscience Source Type: research
LncRNA SNHG12 inhibits miR-199a to upregulate SIRT1 to attenuate cerebral ischemia/reperfusion injury through activating AMPK signaling pathway
Publication date: Available online 22 August 2018Source: Neuroscience LettersAuthor(s): Wei-Lan Yin, Wei-Guo Yin, Bai-Sheng Huang, Li-Xiang WuAbstractCerebral ischemia caused severe disability, and associated with a series of neurological events. Long non-coding RNA SNHG12 was found to be upregulated in mouse brain microvascular endothelial cells by cerebral ischemia. Moreover, it was reported that SNHG12 could directly interact with miR-199a and sirtuin 1 (SIRT1) as a direct target of miR-199a in other diseases. However, the function and mechanism of SNHG12 in cerebral ischemia and reperfusion (I/R) injury of neuronal cel...
Source: Neuroscience Letters - August 23, 2018 Category: Neuroscience Source Type: research
Inhibition of protease-activated receptor 1 ameliorates behavioral deficits and restores hippocampal synaptic plasticity in a rat model of status epilepticus
Publication date: Available online 1 November 2018Source: Neuroscience LettersAuthor(s): Marharyta Semenikhina, Ruslan Bogovyk, Mykhailo Fedoriuk, Oksana Nikolaienko, Lina T. AlKury, Alina Savotchenko, Oleg Krishtal, Elena IsaevaAbstractThe blood-brain barrier (BBB) is a unique structure that controls substances exchange between the systemic circulation and the brain. Disruption of its integrity contributes to the development and progression of a variety of brain disorders including stroke, epilepsy and neurodegenerative diseases. It was shown that intracerebral thrombin level substantially increases following status epile...
Source: Neuroscience Letters - November 2, 2018 Category: Neuroscience Source Type: research
Altered baseline activity and connectivity associated with cognitive impairment following acute cerebellar infarction: A resting-state fMRI study
Publication date: Available online 12 November 2018Source: Neuroscience LettersAuthor(s): Lin Fan, Jun Hu, Wenying Ma, Donghao Wang, Qun Yao, Jingping ShiAbstractThe aims of this study were to investigated the changes of brain function and cognitive function in patients with acute posterior cerebellar infarction using the functional magnetic resonance imaging (fMRI) tecniques: fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC). Forty acute cerebellar infarction patients and 40 healthy controls were included. The differences of fALFF were compared. The regions showed significant diffe...
Source: Neuroscience Letters - November 14, 2018 Category: Neuroscience Source Type: research
Activation of the α7 nicotinic acetylcholine receptor upregulates blood-brain barrier function through increased claudin-5 and occludin expression in rat brain endothelial cells
Publication date: Available online 16 November 2018Source: Neuroscience LettersAuthor(s): Ikuya Kimura, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Yohei Kawahara, Megumi Nishihira, Shohei Sakada, Takuya Saisho, Atsushi Yamauchi, Yasufumi KataokaAbstractThe blood-brain barrier (BBB) is formed by brain endothelial cells (BECs) and regulates brain homeostasis by restricting the entry of blood-borne substances into the brain. Recent in vivo studies have shown that administration of nicotinic acetylcholine receptor (nAChR) agonists protects against BBB disruption and neuroinflammation induced by stroke and traumatic brain ...
Source: Neuroscience Letters - November 16, 2018 Category: Neuroscience Source Type: research
