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Source: Neuroscience Letters
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Total 146 results found since Jan 2013.
EPO promotes axonal sprouting via upregulating GDF10
Publication date: Available online 2 August 2019Source: Neuroscience LettersAuthor(s): Sijia Li, Kefei Cui, Jiajia Fu, Xiaojie Fu, Yufeng Gao, Di Zhang, Zheng fang Lu, Yongxin Zhang, Lie Yu, Jianping WangAbstractErythropoietin (EPO) has an exact neuroprotective effect on stroke. However, it remains unknown whether it participates in axonal sprouting after neuron damage. Growth and differentiation factor 10 (GDF10) has been shown to be a trigger of axonal sprouting after stroke. Hence, it was hypothesized that EPO promotes axonal sprouting mainly through GDF10. In the present in vitro experiment, it was found that EPO could...
Source: Neuroscience Letters - August 4, 2019 Category: Neuroscience Source Type: research
Revealing sex-specific molecular changes in hypoxia-ischemia induced neural damage and subsequent recovery using zebrafish model
Publication date: Available online 10 September 2019Source: Neuroscience LettersAuthor(s): Tapatee Das, Kalyani Soren, Mounica Yerasi, Arvind Kumar, Sumana ChakravartyAbstractFunctional recovery from hypoxia-ischemia depends on an individual’s response to the ischemic damage and recovery. Many of the neurological disorders, including cerebral stroke have sex-specific characteristics. Deciphering the differential molecular mechanisms of sex-specific recovery from hypoxic-ischemic insult can improve medical practice in the treatment of cerebral stroke. In the present study, we describe the establishment of a sex-specific g...
Source: Neuroscience Letters - September 12, 2019 Category: Neuroscience Source Type: research
Neuroprotective effects and dynamic expressions of MMP9 and TIMP1 associated with atorvastatin pretreatment in ischemia–reperfusion rats
In conclusion, Oral administration of atorvastatin before stroke may reduce the severity in I/R injury and improve neurological outcome by lowering MMP9 levels and elevating TIMP1 levels.
Source: Neuroscience Letters - July 30, 2015 Category: Neuroscience Source Type: research
Intravenous PEP-1-GDNF is protective after focal cerebral ischemia in rats
Publication date: 23 March 2016 Source:Neuroscience Letters, Volume 617 Author(s): Yaning Liu, Shangwu Wang, Shijian Luo, Zhendong Li, Fengyin Liang, Yanan Zhu, Zhong Pei, Ruxun Huang Glial cell line-derived neurotrophic factor (GDNF) is a potential therapeutic protein on a variety of central nervous system diseases including ischemic stroke. However, GDNF is a large molecule that cannot cross the blood–brain barrier (BBB), which is still intact in the early hours after stroke when neural rescue is possible. PEP-1 protein transduction domain can deliver protein cargo across the cell membrane and the BBB. In the...
Source: Neuroscience Letters - February 20, 2016 Category: Neuroscience Source Type: research
A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia–reperfusion injury in mice
Publication date: 8 April 2016 Source:Neuroscience Letters, Volume 618 Author(s): Dmitriy N. Atochin, Igor A. Schepetkin, Andrei I. Khlebnikov, Victor I. Seledtsov, Helen Swanson, Mark T. Quinn, Paul L. Huang The c-Jun N-terminal kinase (JNK) has been shown to be an important regulator of neuronal cell death. Previously, we synthesized the sodium salt of 11H-indeno[1,2-b]quinoxalin-11-one (IQ-1S) and demonstrated that it was a high-affinity inhibitor of the JNK family. In the present work, we found that IQ-1S could release nitric oxide (NO) during its enzymatic metabolism by liver microsomes. Moreover, serum nitri...
Source: Neuroscience Letters - March 4, 2016 Category: Neuroscience Source Type: research
Evidence for cerebellar motor functional reorganization in brain tumor patients: An fMRI study
Publication date: 27 May 2016 Source:Neuroscience Letters, Volume 622 Author(s): Satoshi Kurabe, Kosuke Itoh, Tsutomu Nakada, Yukihiko Fujii Functional reorganization of the motor system following brain damage has been studied extensively in stroke patients, in which not only the cerebrum but also the cerebellum (Cbll) undergoes substantial reorganization. However, the role of Cbll in motor functional reorganization in brain tumor patients remains poorly investigated. Because brain damages in brain tumor patients occur much more slowly than in stroke patients, the neural mechanisms for motor functional reorganization...
Source: Neuroscience Letters - April 26, 2016 Category: Neuroscience Source Type: research
Combined damage produced by multiple mild cerebral insults assessed using MRI in neonatal rats
Conclusion The extent of damage produced by a minor neonatal stroke followed by a diffuse HI two days later results in heterogeneous enhancement of T2, ADC and histological injury near the lesion. Surgical procedures including mechanical head manipulation followed by HI also produced some enhanced heterogeneity of hypoxic-ischemic injury affirming the need for sham controls.
Source: Neuroscience Letters - October 3, 2016 Category: Neuroscience Source Type: research
Neural stem cells from mouse strain Thy1 YFP-16 are a valuable tool to monitor and evaluate neuronal differentiation and morphology
In conclusion, stem cells originating from Thy1 YFP-16 mice represent an outstanding tool to monitor neurogenesis enabling morphological analyses of new neurons and their projections, in particular after transplantation in the brain.
Source: Neuroscience Letters - October 4, 2016 Category: Neuroscience Source Type: research
Establishment and characterization of porcine focal cerebral ischemic model induced by endothelin-1
Conclusions The endothelin-1 induced porcine cerebral ischemic model is technically easier, and able to create cerebral ischemia severe enough to cause a functional neurological deficit as well as observable lesions on MRI. It is a suitable model for long-term cerebral ischemia research.
Source: Neuroscience Letters - October 26, 2016 Category: Neuroscience Source Type: research
Delayed administration of the GLP-1 receptor agonist liraglutide improves metabolic and functional recovery after cerebral ischemia in rats
Publication date: 22 February 2017 Source:Neuroscience Letters, Volume 641 Author(s): Wenbin Dong, Yunping Miao, Aiying Chen, Min Cheng, Xiaodi Ye, Fahuan Song, Gaoli Zheng Glucagon-like peptide 1 receptor (GLP-1R) agonists administered before or immediately after induction of experimental stroke have been shown to provide acute neuroprotection. Here, we determined whether delayed treatment with a GLP-1R agonist could improve metabolic and functional recovery after stroke. Rats were subjected to middle cerebral artery occlusion (MCAO) and given the well-established GLP-1R agonist liraglutide (50, 100, or 200μg/kg) or nor...
Source: Neuroscience Letters - January 22, 2017 Category: Neuroscience Source Type: research
Safety of carotid artery stent in repetitive transcranial magnetic stimulation —The histopathological proof from swine carotid artery
Conclusion There was no temperature change, thermal injury or migration after prolonged TBS at a high intensity, suggesting TBS is safe for clinical neuro-rehabilitation and physiological assessments in stroke patients with vascular stents.
Source: Neuroscience Letters - August 24, 2017 Category: Neuroscience Source Type: research
Intravenous administration of retinoic acid-loaded polymeric nanoparticles prevents ischemic injury in the immature brain
Publication date: 23 April 2018 Source:Neuroscience Letters, Volume 673 Author(s): Marta Machado-Pereira, Tiago Santos, Lino Ferreira, Liliana Bernardino, Raquel Ferreira Perinatal stroke is often difficult to diagnose and an established treatment has not yet been validated, except for symptomatic measures. Herein, we propose to test the neuroprotective potential of the intravenous injection of retinoic acid-loaded nanoparticles (RA-NP) upon ischemic injury to the immature brain. The role of RA-NP on endothelial cells and organotypic slice cultures exposed to oxygen and glucose deprivation was assessed by evaluating marke...
Source: Neuroscience Letters - March 20, 2018 Category: Neuroscience Source Type: research
The potential effects of transcranial direct current stimulation (tDCS) on language functioning: Combining neuromodulation and behavioral intervention in aphasia
Publication date: Available online 28 December 2017Source: Neuroscience LettersAuthor(s): Paola MarangoloAbstractAphasia is a highly disabling language disorder usually caused by a left stroke brain damage. Even if traditional language therapies have been proved to induce an adequate clinical recovery, a large percentage of patients are left with chronic deficits at 6 months post-stroke. Therefore, new strategies to common speech therapies are urgently needed in order to maximize the recovery from aphasia. The recent application of transcranial direct current stimulation (tDCS) to language rehabilitation has already provid...
Source: Neuroscience Letters - July 5, 2018 Category: Neuroscience Source Type: research
Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in rats
Publication date: Available online 1 August 2018Source: Neuroscience LettersAuthor(s): Kah Ni Tan, Rebecca Hood, Kirby Warren, Debbie Pepperall, Catalina Carrasco-Pozo, Silvia Manzanero, Karin Borges, Neil J. SprattAbstractTriheptanoin, the medium-chain triglyceride of heptanoate, has been shown to be anticonvulsant and neuroprotective in several neurological disorders. In the gastrointestinal tract, triheptanoin is cleaved to heptanoate, which is then taken up by the blood and most tissues, including liver, heart and brain. Here we evaluated the neuroprotective effects of heptanoate and its effects on mitochondrial oxygen...
Source: Neuroscience Letters - August 2, 2018 Category: Neuroscience Source Type: research
