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Source: Neuroscience Letters
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Total 146 results found since Jan 2013.
Hyperglycemia decreases expression of 14-3-3 proteins in an animal model of stroke
This study investigated 14-3-3 proteins expression in the cerebral cortex of animals with diabetes, cerebral ischemic injury and a combination of both diabetes and cerebral ischemic injury. Diabetes was induced by intraperitoneal injection of streptozotocin (40mg/kg) in adult male rats. After 4 weeks of treatment, middle cerebral artery occlusion (MCAO) was performed for the induction of focal cerebral ischemia and cerebral cortex tissue was collected 24h after MCAO. We confirmed that diabetes increases infarct volume following MCAO compared to non-diabetic animals. In diabetic animals with MCAO injury, reduction of 14-3-3...
Source: Neuroscience Letters - May 24, 2016 Category: Neuroscience Source Type: research
Impaired motor preparation and execution during standing reach in people with chronic stroke
Publication date: 6 September 2016 Source:Neuroscience Letters, Volume 630 Author(s): Sandy McCombe Waller, Chieh-ling Yang, Laurence Magder, Don Yungher, Vicki Gray, Mark W. Rogers Movement preparation of both anticipatory postural adjustments (APAs) and goal directed movement during a standing reaching task in adults with chronic hemiparesis and healthy controls was investigated. Using a simple reaction time paradigm, while standing on two separate force platforms, subjects received a warning light cue to “get ready to reach” followed 2.5s later by an imperative light cue to “reach as quickly as possible”...
Source: Neuroscience Letters - July 26, 2016 Category: Neuroscience Source Type: research
GC-MS-based Metabolomics Identifies an Amino Acid Signature of Acute Ischemic Stroke
Publication date: Available online 19 January 2017 Source:Neuroscience Letters Author(s): Dian Wang, Jing Kong, Jiayan Wu, Xingxing Wang, Minchao Lai Ischemic stroke is a serious public health problem worldwide. Here, we characterized the metabolite features of acute ischemic stroke (AIS) using a gas chromatography-mass spectrometry-based metabolomics. Forty AIS patients and 29 sex and age-matched controls were recruited. The serum metabolic profiles were significantly different between the two groups. Compared to the controls, the patients had elevated levels of lactate, carbonate and glutamate (P<0.01), and lower...
Source: Neuroscience Letters - January 18, 2017 Category: Neuroscience Source Type: research
GC –MS-based metabolomics identifies an amino acid signature of acute ischemic stroke
Publication date: 6 March 2017 Source:Neuroscience Letters, Volume 642 Author(s): Dian Wang, Jing Kong, Jiayan Wu, Xingxing Wang, Minchao Lai Ischemic stroke is a serious public health problem worldwide. Here, we characterized the metabolite features of acute ischemic stroke (AIS) using a gas chromatography-mass spectrometry-based metabolomics. Forty AIS patients and 29 sex and age-matched controls were recruited. The serum metabolic profiles were significantly different between the two groups. Compared to the controls, the patients had elevated levels of lactate, carbonate and glutamate (P<0.01), and lowered level...
Source: Neuroscience Letters - February 2, 2017 Category: Neuroscience Source Type: research
Protective effects of angiopoietin-like 4 on the blood-brain barrier in acute ischemic stroke treated with thrombolysis in mice
Conclusion These findings demonstrated that Angptl4 protects the permeability of the BBB damaged by ischemic and thrombolysis. Suggested that Angptl4 might be a promising target molecule in therapies for vasoprotection after thrombolysis treatment.
Source: Neuroscience Letters - March 9, 2017 Category: Neuroscience Source Type: research
Cerebral White Matter Disease and Microbleeds in Acute Ischemic Stroke: Impact on Recanalization Therapies. A Review of the Literature
Publication date: Available online 5 September 2018Source: Neuroscience LettersAuthor(s): J. Fladt, C. Kronlage, G.M. De MarchisAbstractCerebral white matter disease (WMD) and cerebral microbleeds (CMBs) are frequently seen on brain imaging acquired for acute ischemic stroke.Given the raising use of recanalization therapies - both intravenous and endovascular - the interest on the impact of WMD and CMB on the risk of intracerebral hemorrhage and on functional outcome is growing. In this review, we will discuss the relevance of WMD and CMBs among patients with an acute ischemic stroke, focusing on the implications for recanalization therapies.
Source: Neuroscience Letters - September 6, 2018 Category: Neuroscience Source Type: research
Cerebral White Matter Hyperintensities and Microbleeds in Acute Ischemic Stroke: Impact on Recanalization Therapies. A Review of the Literature
Publication date: 20 November 2018Source: Neuroscience Letters, Volume 687Author(s): J. Fladt, C. Kronlage, G.M. De MarchisAbstractCerebral white matter hyperintensities (WMH) and cerebral microbleeds (CMBs) are frequently seen on brain imaging acquired for acute ischemic stroke. Given the raising use of recanalization therapies - both intravenous and endovascular - the interest on the impact of WMH and CMBs on the risk of intracerebral hemorrhage and on functional outcome is growing. In this review, we will discuss the relevance of WMH and CMBs among patients with an acute ischemic stroke, focusing on the implications for...
Source: Neuroscience Letters - October 4, 2018 Category: Neuroscience Source Type: research
Nitrogen-doped carbon nanocages and human umbilical cord mesenchymal stem cells cooperatively inhibit neuroinflammation and protect against ischemic stroke
This study aimed to explore the synergistic effects of nitrogen-doped carbon nanocages (NCNCs) and human umbilical cord mesenchymal stem cells (HUC-MSCs) on ischemic stroke and investigate the potential underlying mechanisms.Main methodsThe properties of NCNCs were analyzed by transmission electron microscopy, and the markers of HUC-MSCs were detected by flow cytometry. The cell toxicity of NCNCs was evaluated by MTT. Mice were induced cerebral infarction by transient middle cerebral artery occlusion (MCAO). NCNCs or HUC-MSCs or HUC-MSCs-NCNCs were intravenously injected thirty minutes after reperfusion. The infarct volume...
Source: Neuroscience Letters - June 21, 2019 Category: Neuroscience Source Type: research
Dose-dependent effects of tetramethylpyrazine on the characteristics of human umbilical cord mesenchymal stem cells for stroke therapy
This study determined the dose-dependent effects of tetramethylpyrazine (TMP) on the characteristics of ucMSCs in vitro. The effect on proliferation was determined with Cell Counting kit-8 assays. Cell migration was analyzed with Transwell assays and western blot analysis. Differentiation of ucMSCs was evaluated according to markers and the expression of relevant proteins and genes. Secretion capacity was detected by ELISA analysis. TMP protected ucMSCs against H2O2 induced-oxidative damage but had no influence on ucMSC activity at a low concentration. Furthermore, ucMSC migration was improved by TMP via the SDF-1/CXCR4 ax...
Source: Neuroscience Letters - February 15, 2020 Category: Neuroscience Source Type: research
Ceftriaxone pretreatment reduces the propensity of postpartum depression following stroke during pregnancy in rats
Conclusions Taken together, our results suggested that ceftriaxone pretreatment before brain ischemia during pregnancy may reduce the propensity for the development of PPD by preventing the loss of GLT-1 expression in the mPFC.
Source: Neuroscience Letters - August 23, 2016 Category: Neuroscience Source Type: research
Astrocyte activation and reactive gliosis—A new target in stroke?
Publication date: Available online 17 July 2018Source: Neuroscience LettersAuthor(s): Milos Pekny, Ulrika Wilhelmsson, Turgut Tatlisumak, Marcela PeknaAbstractStroke is an acute insult to the central nervous system (CNS) that triggers a sequence of responses in the acute, subacute as well as later stages, with prominent involvement of astrocytes. Astrocyte activation and reactive gliosis in the acute stage of stroke limit the tissue damage and contribute to the restoration of homeostasis. Astrocytes also control many aspects of neural plasticity that is the basis for functional recovery. Here, we discuss the concept of int...
Source: Neuroscience Letters - July 18, 2018 Category: Neuroscience Source Type: research
Asymmetries in force matching are related to side of stroke in right-handed individuals
Publication date: Available online 25 July 2018Source: Neuroscience LettersAuthor(s): Charlie Anderson, Kumar Rajamani, Victoria Pardo, Diane E. AdamoAbstractAsymmetries in grasp force matching extend beyond quantifying a single measure of maximum grip strength and advance our application of side-specific treatment interventions. A cross sectional study design investigated grasp-force matching performance in right-handed individuals with a stroke and age-matched healthy controls. A visual representation of the 20% Maximum Voluntary Contraction (MVC) was matched in three conditions in the absence of visual feedback with the...
Source: Neuroscience Letters - July 26, 2018 Category: Neuroscience Source Type: research
Glutamate receptors and white matter stroke
Publication date: Available online 23 November 2018Source: Neuroscience LettersAuthor(s): Robert Fern, Carlos MatuteAbstractWhite matter (WM) damage during ischemia occurs at multiple sites including myelin, oligodendrocytes, astrocytes and axons. A major driver of WM demise is excitoxicity as a consequence of excessive glutamate release by vesicular and non-vesicular mechanisms from axons and glial cells. This results in over-activation of ionotropic glutamate receptors profusely expressed by all cell compartments in WM. Thus, blocking excitotoxicity in WM with selective antagonists of those receptors has a potential ther...
Source: Neuroscience Letters - November 24, 2018 Category: Neuroscience Source Type: research
Influence of unilateral spatial neglect on vertical perception in post-stroke pusher behavior
Publication date: Available online 30 November 2019Source: Neuroscience LettersAuthor(s): Kazuhiro Fukata, Kazu Amimoto, Yuji Fujino, Masahide Inoue, Mamiko Inoue, Yosuke Takahashi, Daisuke Sekine, Shigeru Makita, Hidetoshi TakahashiAbstractPusher behavior (PB) impairs verticality in the frontal plane and is often associated with unilateral spatial neglect (USN). However, it is unclear whether USN affects verticality among patients with PB. We aimed to clarify the characteristics of verticality among PB, with and without USN. The study included 43 patients with right hemisphere stroke, including 12 without PB or USN, 10 wi...
Source: Neuroscience Letters - December 1, 2019 Category: Neuroscience Source Type: research
Effects of the multisensory rehabilitation product for home-based hand training after stroke on cortical activation by using NIRS methods
ConclusionsAccording to these results, MFTOM-induced cortical activation in the MC, PFC and TL with visual, auditory and tactile stimuli was stronger than SFTOM, providing evidence that the multisensory stimulation is more beneficial to cortical activation and cognitive control to promote neurological recovery.
Source: Neuroscience Letters - December 17, 2019 Category: Neuroscience Source Type: research
