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Pharmacological intervention of histone deacetylase enzymes in the neurodegenerative disorders
Publication date: Available online 8 January 2020Source: Life SciencesAuthor(s): Rohan Gupta, Rashmi K. Ambasta, Pravir KumarAbstractReversal of aging symptoms and related disorders are the challenging task where epigenetic is a crucial player that includes DNA methylation, histone modification; chromatin remodeling and regulation that are linked to the progression of various neurodegenerative disorders (NDDs). Overexpression of various histone deacetylase (HDACs) can activate Glycogen synthase kinase 3 which promotes the hyperphosphorylation of tau and inhibits its degradation. While HDAC is important for maintaining the ...
Source: Life Sciences - January 9, 2020 Category: Biology Source Type: research

Post-ischemic administration of dopamine D2 receptor agonist reduces cell death by activating mitochondrial pathway following ischemic stroke
Publication date: Available online 24 August 2020Source: Life SciencesAuthor(s): Pooja Kaushik, Mubashshir Ali, Heena Tabassum, Suhel Parvez
Source: Life Sciences - August 25, 2020 Category: Biology Source Type: research

Advanced non-invasive MRI of neuroplasticity in ischemic stroke: Techniques and applications
Publication date: Available online 29 August 2020Source: Life SciencesAuthor(s): Chao Sun, Xuehuan Liu, Cuiping Bao, Feng Wei, Yi Gong, Yiming Li, Jun Liu
Source: Life Sciences - August 30, 2020 Category: Biology Source Type: research

Donepezil in the treatment of ischemic stroke: Review and future perspective
Publication date: Available online 12 October 2020Source: Life SciencesAuthor(s): Arnavaz Hajizadeh Barfejani, Mahbod Jafarvand, Seyed Mohammad Seyedsaadat, Roozbeh Tarighati Rasekhi
Source: Life Sciences - October 13, 2020 Category: Biology Source Type: research

Repurposing metformin to treat age-related neurodegenerative disorders and ischemic stroke
Publication date: Available online 11 March 2021Source: Life SciencesAuthor(s): Sejal Sharma, Saeideh Nozohouri, Bhuvaneshwar Vaidya, Thomas Abbruscato
Source: Life Sciences - March 11, 2021 Category: Biology Source Type: research

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